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I3C SAP

Nutritional Fundamentals for Health

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I3C SAP product image
SKU: NFH-1066
Indole-3-carbinol (I3C) is a phytochemical derived in high concentrations from the Brassica family of vegetables, including broccoli, cauliflower, Brussels sprouts, and cabbage. I3C and its derivative compounds have been shown to exert anticancer mechanisms in the human body. I3C has been shown to exhibit direct antiestrogenic activity via competitive inhibition of estrogen receptors; upregulate the cytochrome P450 isoenzymes CYP1A1, CYP1A2, and CYP1B1, thereby increasing estrogen metabolism; shift estrogen metabolism away from the more proliferative (16‑OHE1) towards the more protective (2‑OHE1) estrogen species; induce cancer cell apoptosis via NF‑κB pathways; inhibit cancer cell growth at the G1 stage; and increase the expression of p21, p27 and p53 tumor suppressors. The use of I3C for the prevention and treatment of breast, endometrial, colon, and prostate cancers as well as for the treatment of herpes simplex virus (HSV) and human papillomavirus (HPV), including cervical dysplasia and cervical cancer, has been studied in depth in both animals and humans with favourable results.
Take 1-3 capsules daily or as directed by your licensed health-care practitioner.



Serving Size: 1 Capsule

Amount Per Serving
Indole-3-carbinol ... 150mg

Other Ingredients: Vegetable magnesium stearate, microcrystalline cellulose, and a non‐GMO vegetable capsule composed of vegetable hypromellose and purified water.

Does not contain gluten, wheat, corn, dairy, sugar, starch, yeast, preservatives, artificial flavor or color.
Do not use if seal is broken. 
Keep out of reach of children.

Cautions and warnings: For adult use only. Consult a health-care practitioner prior to use if you are taking any medication; if you are attempting to conceive; if you have a liver disorder or develop liver related symptoms (e.g. abdominal pain, jaundice, dark urine); if you have or are pre-disposed to cancer. Discontinue use if you experience joint pain or hot flashes. Do not use if you are pregnant or breastfeeding.

Contraindications: Consult a health-care practitioner prior to use if using anti-estrogenic drugs.

Known adverse reactions: Hypersensitivity is known to occur; in which case, discontinue use. Discontinue use and consult a health-care practitioner if you develop a rash or gastrointestinal upset.
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