SAMe

S-Adenosyl-L-Methionine (SAMe) has several critical physiological functions and is the common thread between three key metabolic pathways. Well-recognized as a unique methyl donor for numerous biological reactions, including DNA methylation, it also links methylation to polyamine synthesis (necessary for cell survival and growth), and trans sulfuration, which is responsible for cysteine production, the rate-limiting factor in glutathione synthesis. Its unique positioning within these intersecting pathways explain its role as a regulator of redox status, cellular metabolism, proliferation and apoptosis.

Clinically it has proven beneficial for a number of conditions, most notably osteoarthritis, neurodegenerative disease, depression and liver disease. For patients with major depressive disorder, SAMe has been shown to be effective not only when compared to standard antidepressants, but also for selective serotonin reuptake inhibitor (SSRI) nonresponders. SAMe has also shown efficacy for osteoarthritis comparable to NSAIDs, including celecoxib. Quite importantly, it is likely via increases in cartilage formation, glutathione production, DNA methylation and gene expression which contribute to its efficacy, a stark contrast from pharmaceutical analgesics. Research also suggests benefit for neurodegenerative disease, and potentially for improving endothelial function.

Benefits
•Key factor in several key biological pathways, including methylation reactions, glutathione formation and glutathione-s-transferase activity
•Complexed with disulfate tosylate, a well-tolerated, stable and clinically tested form
•Enteric coating protects SAMe degradation from gastric acid, allowing for significantly improved intestinal absorption
•200 mg SAMe per tablet, allows for flexible dose titration
•Sourced from the highest quality Italian Isoactive® SAMe available on the market
•Isoactive SAMe uses a natural fermentation process that yields 40% higher active ingredients over synthetic variations

Take on an empty stomach:

For mood balance: 1–4 tablets 2 times per day or as directed by a health care professional.

For joint support: 1–3 tablets 2 times per day or as directed by a health care professional. Do not exceed a total of 8 tablets per day. SAMe must be taken for a minimum of 2 weeks, at which time effects should be observed.

Serving Size: 1 Tablet

Amount Per Serving
SAMe S-Adenosyl-L-Methionine ... 200mg
(from 400 mg SAMe Tosylate Disulfate)

Other ingredients: Microcrystalline cellulose, mannitol, enteric coating (methacrylic acid copolymer, triethyl citrate, glyceryl palmitostearate, silica, titanium dioxide, medium chain triglycerides (coconut), yellow iron oxide), glyceryl behenate, magnesium stearate (vegetable grade), silica, sodium starch glycolate.

Contains no artificial preservatives or sweeteners; no dairy, gluten, soy, wheat or yeast.

Sealed for your protection. Do not use if seal is broken. For freshness, store in a cool, dry place.

If you are taking antidepressant medications, consult a health care professional prior to taking SAMe in place of or in addition to those medications. Not recommended for use in children. Do not use if you are pregnant or breastfeeding. Do not take at night as SAMe may cause anxiety, restlessness, insomnia. People with bipolar disorder or (manic-depressive illness) should not use SAMe unless under medical supervision. Possible side effects are: mild gastrointestinal upsets, anxiety, hyperactive muscle movement, insomnia and hypomania. When these side effects occur, they often diminish with time or resolve with lower doses or cessation of use. There are no documented cases of allergies to SAMe. SAMe could theoretically worsen Parkinson’s symptoms, although this has not been observed clinically. Keep out of reach of children.

Deficiency of vitamins B6, B12, and other methyl donors may exacerbate SAMe deficiency. Theoretically may have additive serotonergic effects when used with antidepressants, but this has not been observed clinically, and when used simultaneously, no increase in adverse effects were noted compared to placebo.