Skip to main content

Up to 25% off products when you checkout or sign up


  • Egg free

  • Peanut free

  • Tree nut free

  • NSF Certified

  • cGMP

  • Soy free

  • Wheat free

  • NSF Certified for Sport

  • Milk free

  • Fish free

Methyl-Plex B™ is a comprehensive formula designed to support healthy homocysteine levels and optimal methylation.* The 5-MTHF in this formula – Quatrefolic® – is the most biologically active form of folate, allowing rapid uptake into the bloodstream.* The 5-MTHF in this formula is also known as the "L" form of 5-MTHF since it is the reduced form of folate. B vitamins are provided in their active forms to support enhanced methylation and cardiovascular health.*


Suggested Use / Directions:
Take one capsule per day or as directed by your healthcare practitioner.

Serving Size:
1 Capsule

Amount Per Serving:

Riboflavin (Vitamin B2) (as riboflavin-5'-phosphate) ... 25 mg
Vitamin B6 (as pyridoxal-5'-phosphate) ... 25 mg
Folate ... 2,040 mcg DFE
(as 600 mcg (6S)-5-methyltetrahydrofolic acid, glucosamine salt*, and 600 mcg (6S)-5-methyltetrahydrofolic acid, calcium salt)
Vitamin B12 (as methylcobalamin) ... 1,000 mcg
Trimethylglycine (as anhydrous betaine) ... 500 mg


Other Ingredients:
Hydroxypropyl methylcellulose (vegetable capsule), microcrystalline cellulose, magnesium stearate, silicon dioxide.

Does Not Contain: Milk, eggs, fish, shellfish, tree nuts, peanuts, wheat, soy.
Caution: Keep out of reach of children

Storage: Keep tightly closed in a cool, dry place

Methyl-Plex B™

NuMedica

$33.99

Sign up for exclusive store pricing

Shop the entire wellness catalog, held to a higher standard

Shop 50K+ practitioner-grade products, each meeting the same bar for quality through Fullscript's standards.

Powered by
Sign up to shop
  • Tested

    Independent lab testing backs the label

  • Verified

    Every brand is vetted for identity and purity

  • Trusted

    Relied on by 135k+ practitioners nationwide