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  • Gluten free

  • Vegan

  • Non-GMO

  • Vegetarian

  • Organic

  • Lion's Mane for Brain Support: This mushroom supplement supports immune and nervous system health as well as brain health, making it an ideal dietary supplement for those wanting to aid their focus and memory*
  • Dietary Supplement with Mushroom Mycelium: Our brain and focus support supplement is formulated with Lion's Mane, "The Smart Mushroom," for daily brain support*
  • About Host Defense: Host Defense Mushrooms was founded by renowned mycologist Paul Stamets; our mushroom mycelium is certified organic, non-GMO, gluten-free, and grown in the USA*
  • Powered by Mushroom Mycelium: Our organic mushroom mycelium is grown on organic brown rice substrate; third-party studies show that mushroom mycelium and fermented rice substrate support your health*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested Use / Directions:
As a dietary supplement, take 2 capsules once per day. Can be taken with food or on an empty stomach or as recommended by your healthcare professional.

Serving Size:
2 capsules

Amount Per Serving:

Calories ... 5
Total Carbohydrate ... <1 g
Lion’s Mane (Hericium erinaceus) mycelium‡/fermented brown rice biomass‡ ... 1 g


Other Ingredients:
Pullulan (capsule).


Caution: If you have a medical condition, are taking medications, or are pregnant or breastfeeding. consult a healthcare professional before using this product. Keep out of reach of children.
Why is this a top pick for Lion's mane?

This product has been chosen as a Top Pick by Fullscript based on factors like quality, ingredients, value, and availability. Your provider’s recommendation always comes first.

This product was selected based on the factors below: Activated, optimally dried organic Lion’s Mane mycelium provides a full spectrum of polysaccharides, hericenones, erinacines and prebiotic fibers. Preclinical (in vitro) studies show hericenones and erinacines may support nerve growth factor synthesis, polysaccharides may support macrophage and NK-cell activity, and prebiotic fibers support the gut microbiome. No published trials have evaluated Host Defense’s proprietary activated mycelium formula. USDA-organic, non-GMO, third-party tested for contaminants.*

Learn more about our process

About enhanced testing

Every product on Fullscript meets our high quality standards – but we don’t stop there. Enhanced Testing means select products are pulled directly from Fullscript’s shelves and tested by independent labs, so what’s on the label matches what’s in the product.

Learn more about the testing methods

Top pick

Enhanced testing

Lions Mane (Hericium erinaceus)

Host Defense

$20.99

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