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  • Gluten free

  • cGMP

  • Soy free

  • Vegan

  • Non-GMO

  • Wheat free

  • Salt free

  • Sugar free

  • Rice free

  • Artificial Color / Colour Free

Mega SporeBiotic™ is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria.

MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

Bacillus Licheniformis

  • Produces proteases that aid protein digestion
  • Produces full spectrum of B vitamins


Bacillus Indicus HU36™

  • Produces carotenoids: lycopene, astaxanthin, beta-carotene, and lutein
  • Produces quinols and vitamins


Bacillus Subtilis HU58™

  • Produces nattokinase and vitamin K2
  • Supports healthy GALT development


Bacillus Clausii

  • Supports immune function


Bacillus Coagulans

  • Produces L+ optical form of lactic acid
  • Supports immune function

Suggested Use / Directions:
Week 1: 1 capsule every other day
Week 2: 1 capsule daily
Week 3+: 2 capsules daily
If 1 capsule every other day causes side effects, try starting with 1/2 capsules or even 1/4 capsule in some cases. Possible side effects may include abdominal cramping, loose stools, and changes in bowel movements. Though these side effects may be uncomfortable, they are a sign that the product is working! Side effects should resolve within 2-3 days.


Serving Size:
2 Capsules

Amount Per Serving:

Proprietary Probiotic Blend ... 295 mg
Bacillus indicus (HU36™)
Bacillus licheniformis (SL-307)
Bacillus clausii (SC-109)
Bacillus subtilis (HU58™)
Bacillus coagulans (SC-208)



Other Ingredients:
Cellulose, vegetable capsule (cellulose and water).

Does not contain eggs, dairy, gluten, nuts, soy, wheat


If you are pregnant or nursing, taking any medication, or have a medical condition, consult your doctor before using this product. Keep out of reach of children. Do not use if safety seal is broken or missing.
Why is this a top pick for Bacillus (Spore-based)?

This product has been chosen as a Top Pick by Fullscript based on factors like quality, ingredients, value, and availability. Your provider’s recommendation always comes first.

This product was selected based on the factors below: MegaSporeBiotic™ is a 4 billion CFU spore-based shelf-stable probiotic blend of five clinically studied Bacillus species (including HU36™, HU58™, SC-208, SL-307, and SC-109) formulated to support gut barrier integrity, microbial diversity, and immune function. Its spores are designed to survive gastric conditions and activate in the intestine, where they help maintain a healthy gut environment.*

Learn more about our process

Top pick

Mega SporeBiotic™

Microbiome Labs

$66.99

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