Regenexx Musculoskeletal

2 Capsules

twice per day

For 6 months

Additional notes

"*in divided doses, with 8 oz water, with meals Glucosamine and chondroitin are natural components of cartilage. Glucosamine is a building block of cartilage, and chondroitin helps the cartilage retain water. Glucosamine and chondroitin for supplementation are usually made by breaking down shellfish or other animal by-products. They are safe supplements for long-term use, and there are few known side effects. Many studies have shown that they relieve pain and improve function in patients with arthritis. Ligament Restore* is a blend of collagen and essential vitamins to help maintain healthy tendons, ligaments and joints. Ligament Restore* helps to support the natural repair process of healthy connective tissue.* Supports collagen formation for healthy tendons, ligaments and joints* May help recovery from strains, sprains and overall wear and tear* Provides glucosamine sulfate as a building block for tendons, ligaments, and joints; enhances the natural repair processes of healthy connective tissue; protects cartilage from the effects of mechanical stress* Contains BioCell Collagen®, a naturally occurring blend of hyaluronic acid (HA), chondroitin sulfate, glucosamine sulfate and amino acids to promote cartilage synthesis and joint integrity* Encourages collagen formation with l-lysine and l-proline, forming the “glue” that holds collagen together* Includes silica and vitamin C as cofactors for connective tissue matrix formation and repair* Maintains joint comfort with devil’s claw and curcumin* Helps recovery from strains and sprains or overall wear and tear* Best taken daily to maintain connective tissue resiliency*"

2 Gels

once per day

For 6 months

Additional notes

"2000 mg EPA+DHA per serving Highest-concentration triglyceride-form omega oil Fish oils suppress the formation of inflammatory cytokines and eicosanoids and this is believed to be associated with less pain and inflammation. However, rather than shutting down the COX inflammatory pathway (like NSAID drugs-so called “COX inhibitors”) they are metabolized by that pathway into powerful anti-inflammatory molecules known as the resolvins and the protectins. These have been shown to have many effects, not the least of which is activating the the recovery process of inflammation. So unlike NSAID’s (Motrin, Alleve, Ibuprofen, Voltaren, Celebrex) which block an important inflammation pathway and cause sudden death via heart attacks and fatal stomach ulcers, fish oil increases good molecules that can control inflammation. They also do more than just turn down the inflammation knob, they switch inflammation from a bad chronic state to a good recovery state. That last inflammation recovery function likely needs a little explanation. Inflammation is good as it’s the body’s process to allow repair. Treatments like prolotherapy increase acute inflammation to allow tissue repair. However, acute inflammation from an ankle sprain is to be distinguished from it’s evil twin brother-chronic inflammation. This is the kind of inflammation that leads to heart attacks and other chronic diseases and is increased in patients with metabolic syndrome (overweight, high blood pressure, high triglycerides, pre-diabetes). So the fish oil effect that leads to molecules that move inflammation toward recovery phase means that chronic inflammation (which never gets to that recovery phase) gets moved toward something that looks more like helpful acute inflammation (which has a recovery phase). To use another analogy, chronic inflammation is like trying to bake a cake in a 200 degree oven. The oven isn’t hot enough to trigger the chemical processes that “bake” the cake-so all you get is mush. This is like chronic inflammation. However, turn the heat up to 400 degrees, and you get a “baked” cake (this is like acute inflammation). So increasing the recovery phase of inflammation is like turning the heat up in the oven. Which components of fish oil help arthritis? There are a number of different component fatty acids that have been studied, the best known of which are DHA, EPA, and AA. EPA has been shown in a recent study to block the bad chemicals that lead to cartilage degeneration. DHA also has the same, but lesser effect. Another lab study also found that EPA was better than DHA or AA in reducing bad cartilage breakdown chemicals. Finally, a third recent study concluded the same thing (EPA>DHA). DHA was also strongly associated with modulating pain. It up regulates “feel good” endorphins much more strongly than other types of unsaturated fat (in this case olive oil). - Christopher Centeno, MD"

2 Gels

once per day

For 6 months

Additional notes

"**You may take up to 10 per day during pain flares or for post-procedure discomfort. Turmeric and curcumin are derived from the turmeric root with turmeric being the spice you know from Indian cooking, and curcumin one of the chemical compounds known as curcuminoids, which are believed to be biologically active. In one study that used adipose MSCs to treat heart attacks, curcumin improved the viability of the cells, reduced scarring in the heart muscle being repaired, and promoted new blood vessel formation (1). In another involving bone marrow MSCs, curcumin improved bone formation (2). The curcuminoids also impact arthritis through anti-inflammatory pathways, down-regulating enzymes such as phospholipase A2, cyclooxygenase-2, and lipoxygenases, and reducing inflammatory cytokines like TNF-alpha-and interleukin-1β (IL-1β), IL-6, and IL-8 (19). All of these effects have translated into real measurable impacts on patients with knee arthritis (20, 23,24). In other studies, Curcumin has been shown to be as effective as common NSAID anti-inflammatories such as Diclofenac and Ibuprofen (21,22). - Christoper Centeno, MD Curapro features a minimum of 500 mg of curcuminoids per softgel: • Results verified in more than 60 PUBLISHED STUDIES, 27 HUMAN CLINICAL TRIALS • Supports liver, brain, heart, and immune health* • Protects cells from oxidative stress and free radicals* • High antioxidant ORAC value >1,500,000** • Patent-protected method using curcumin blended with turmeric essential oil containing ar-turmerone to boost absorption and enhance results CuraPro® is up to 500 times more powerful than turmeric, and has a sustained retention time at meaningful levels in the bloodstream.^ This high-potency formula, featuring a clinically studied curcumin, yields a minimum of 250 mg of curcuminoids per softgel. (1) Liu J, Zhu P, Song P, Xiong W, Chen H, Peng W, Wang S, Li S, Fu Z, Wang Y, Wang H. Pretreatment of adipose derived stem cells with curcumin facilitates myocardial recovery via antiapoptosis and angiogenesis. Stem Cells Int. 2015;2015:638153. doi: 10.1155/2015/638153 (2) Gu Q, Cai Y, Huang C, Shi Q, Yang H. Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation. Pharmacogn Mag. 2012;8:202–208. doi: 10.4103/0973-1296.99285. (19) Akuri MC, Barbalho SM, Val RM, Guiguer EL. Reflections about Osteoarthritis and Curcuma longa. Pharmacogn Rev. 2017;11(21):8–12. doi:10.4103/phrev.phrev_54_16 (20) Henrotin Y, Malaise M, Wittoek R, et al. Bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: a double-blind multicenter randomized placebo controlled three-arm study. Arthritis Res Ther. 2019;21(1):179. Published 2019 Jul 27. doi:10.1186/s13075-019-1960-5 (21) Shep D, Khanwelkar C, Gade P, Karad S. Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials. 2019;20(1):214. Published 2019 Apr 11. doi:10.1186/s13063-019-3327-2 (22) Kuptniratsaikul V, Dajpratham P, Taechaarpornkul W, et al. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: a multicenter study. Clin Interv Aging. 2014;9:451–458. Published 2014 Mar 20. doi:10.2147/CIA.S58535 (23) Panahi Y, Rahimnia AR, Sharafi M, Alishiri G, Saburi A, Sahebkar A. Curcuminoid treatment for knee osteoarthritis: a randomized double-blind placebo-controlled trial. Phytother Res. 2014 Nov;28(11):1625-31. doi: 10.1002/ptr.5174. (24) Rahimnia AR, Panahi Y, Alishiri G, Sharafi M, Sahebkar A. Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial. Drug Res (Stuttg). 2015 Oct;65(10):521-5. doi: 10.1055/s-0034-1384536."

1 Capsule

once per day

For 6 months

Additional notes

"with a meal. Low Vitamin D levels are extremely common in the Pacific Northwest. Low vitamin D levels can lead to increased general pain and may play a role in arthritis progression. Therefore, we like all of our patients to supplement Vitamin D if they are not already doing so."

1 Scoop

once per day

For 6 months

Additional notes

"Collagen powder supports your body's collagen production, bone strength, joint health and integrity, skin elasticity and more. Collagen is a special type of protein that accounts for as much as 30% of the body’s total protein. In particular, it’s a primary structural component of connective tissue. The amino acid composition of dietary collagens are very similar to those in human collagens, making dietary collagen peptides ideal for supporting normal body collagen turnover and renewal. Many individuals—the elderly in particular—do not consume adequate protein. Even among those with a higher protein intake, the richest sources of collagen—animal skins, bone broth, and tendons — are not typically part of the modern Western diet. Collagen can be incorporated into shakes, smoothies, and other foods and beverages, making it a convenient way to ensure adequate intake of collagen’s unique amino acids."

2 Capsules

once per day

For 6 months

Additional notes

"The patented blend called NT-020 in Stem XCell™ Pro was developed by leading university scientists. Scientific data gathered from studying NT-020 suggests supplementation promotes the growth and health of stem cells encouraging cell renewal.* This unique blend has been enhanced by the addition of Enzymedica enzymes to improve nutrient and antioxidant values.* Take 2 capsules daily. More may be taken as recommended by a healthcare professional. Serving Size: 2 capsules Amount Per Serving Vitamin D3 ... 2, 000IU (as cholecalciferol) Proprietary Blend NT-020 ... 800mg Green Tea Extract (leaf) Blueberry Lowbush Powder (fruit) (vaccinium corymbosum) Carnosine BioVin® Advanced Red Grape Extract (Vitis vinifera) (fruit) (5% resveratrol) VitaBlue® Blueberry Extract (fruit) Botanical Enhance Enzymes ... 25mg Hemicellulase 3, 000 HCU Cellulase 200 CU Xylanase 250 XU Pectinase (w/phytase) 5 Endo-PGU Defenze™ Antioxidant Blend ... 25mg Catalase 12.5 Baker Superoxide Dismulase (SOD) 4mg Alpha Lipoic Acid 4mg Protease Thera-Blend™ 2, 500 HUT Glutathione (reduced) 3mg Other Ingredients: 100% Vegetarian Capsule (cellulose, water) Contains NO: egg, dairy, preservatives, salt, sucrose, soy, yeast, casein, potato, rice, corn, wheat, gluten, nuts, artificial colors or flavors Consult a physician prior to use if you are pregnant or nursing. Keep closed in dry place; do not expose to excessive heat. Keep out of the reach of children."