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  • Gluten free

  • Dairy free

  • Non-GMO

  • Milk free

  • Vegetarian

Homocysteine Supreme™ contains synergistic nutrients, including folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate, which supports efficient metabolism of homocysteine.

This supplement helps maintain a healthy homocysteine pathway, promoting the normal production of important end products such as the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine.

An optimally functioning homocysteine pathway provides methyl and sulfur groups essential for biochemical reactions that support detoxification, healthy immune function, ideal joint and cartilage structure, as well as brain and cardiovascular health.*

Homocysteine Supreme™ is gluten-free, dairy-free, soy-free, vegetarian, and non-GMO, delivered in vegetable capsules for oral administration. Suggested use is 2 capsules per day with meals or as directed by a healthcare practitioner.


Suggested Use / Directions:
Take 2 capsules per day with meals or as directed by your health-care practitioner.

Serving Size:
2 capsules

Amount Per Serving:

Riboflavin (as Riboflavin-5-Phosphate) ... 30 mg
Vitamin B-6 (as Pyridoxal-5-Phosphate) ... 10 mg
Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt) ... 3400 mcg DFE
Vitamin B-12 (as Methylcobalamin) ... 1000 mcg
Trimethylglycine (TMG) ... 900 mg
L-serine ... 100 mg


Other Ingredients:
Cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.

GLUTEN-FREE, DAIRY FREE, SOY FREE, VEGETARIAN, NON-GMO

Keep out of reach of children. Store at room temperature. 

Why is this a top pick for Methylation support?

This product has been chosen as a Top Pick by Fullscript based on factors like quality, ingredients, value, and availability. Your provider’s recommendation always comes first.

This product was selected based on the factors below: Provides activated B vitamins—B2 (riboflavin-5-phosphate), B6 (pyridoxal-5-phosphate), B9 (Quatrefolic® 5-MTHF), and B12 (methylcobalamin)—along with Trimethylglycine (TMG) and L-serine to support methylation and homocysteine metabolism. Ingredients: Vitamin B9 sourced from patented Quatrefolic® 5-methyltetrahydrofolate. Vitamin B12 source is methylcobalamin as MecobalActive® ingredient. Manufactured in a cGMP facility and third party tested for potency and purity.*

Learn more about our process

About enhanced testing

Every product on Fullscript meets our high quality standards – but we don’t stop there. Enhanced Testing means select products are pulled directly from Fullscript’s shelves and tested by independent labs, so what’s on the label matches what’s in the product.

Learn more about the testing methods

Top pick

Enhanced testing

Homocysteine Supreme

Designs for Health

$31.99

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