††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.

B-Supreme is a powerful combination of B vitamins supplied mostly in their coenzymated forms, so that the body does not have to phosphorylate them to be used in biochemical reactions. This formula also includes the patented folate derivative Quatrefolic®, which is an innovative form of folate that has demonstrated high bioavailability, solubility, and long-lasting stability. Trimethylglycine (TMG) and choline are also included to support methylation.

Suggested Use / Directions:
Take 1 capsule per day or as directed by your health-care practitioner

Serving Size:
One Capsule

Amount Per Serving:
Thiamin ... 100mg
(as Thiamin HCl)
Riboflavin ... 50mg
(Vitamin B-2)(as Riboflavin and Riboflavin-5-Phosphate)
Niacin ... 50mg NE
(as Niacinamide)
Vitamin B-6 ... 50mg
(as Pyridoxine HCl and Pyridoxal-5-Phosphate)
Folate ... 340 mcg DFE
[6S]-5-methyltetrahydrofolate. glucosamine salt)
Vitamin B-12 ... 250 mcg
(as Methylcobalamin)
Biotin ... 2000 mcg
(as d-Biotin)
Pantothenic Acid ... 100mg
(as d-Calcium Pantothenate)
Choline … 30mg
(as Choline Dihydrogen Citrate)
Trimethylglycine ... 200mg
(TMG)

Other Ingredients:
Cellulose (capsule), stearates (vegetable source), silicon dioxide.

NOTICE
Color, size or shape may appear different between lots.

Store at room temperature. Keep out of reach of children.