††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.

SAMe is a naturally occurring metabolite found in the human body as well as in plant and animal foods. It is the most active of all methyl donors and has been compared to ATP in its importance for the body. SAMe is naturally synthesized in humans from the amino acid methionine in the presence of the cofactors B12 and folate.

SAMe is involved in the synthesis of neurotransmitters, the hormone melatonin, phospholipids, and polyamines, which control cellular growth. It is also the source of methyl groups inside the nucleus for DNA methylation, which controls gene expression and masking of genetic damage.

These capsules provide 200 mg of SAMe along with vitamins B6, B12, and folate as 5-MTHF in order to provide cofactors for the natural conversions of SAMe to L-homocysteine and then safely to L-cysteine.

Made with non-GMO ingredients.

Suggested Use / Directions:
As a dietary supplement, take one capsule per day, preferably on an empty stomach, or as directed by your health care practitioner.

Serving Size:
1 capsule

Amount Per Serving:

Vitamin B-6 (as Pyridoxal-5-Phosphate) ... 5 mg
Folate (as Quatrefolic® [6S]-5-Methyltetrahydrofolate, glucosamine salt 200 mcg) ... 170 mcg DFE
Vitamin B-12 (as Methylcobalamin) ... 50 mcg
SAMe (as S-Adenosyl-L-Methionine from SAMe Powder - S-Adenosyl-L-Methionine P-Tolensulfate, Calcium Chloride and Calcium Oxide) ... 200 mg

Other Ingredients:
Cellulose (capsule), microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide.

Other Ingredients: Cellulose (capsule), microcrystalline cellulose, vegetable stearate, calcium chloride anhydrous, calcium oxide.

This product does not contain gluten.

NOTICE
Color, size or shape may appear different between lots.

Store at room temperature. Keep out of reach of children.