Gluten free
Dairy free
Non-GMO
Milk free
Vegetarian

††USA Functional Medicine MDs, DOs, NDs, DCs and Nutrition Professionals surveyed in 2025 for Designs for Health.

Homocysteine Supreme™ contains synergistic nutrients, including folate in the bioidentical, bioactive form, 5-methyltetrahydrofolate, known to facilitate the efficient metabolism of homocysteine. Homocysteine Supreme™ maintains a healthy homocysteine pathway, allowing for the normal production of its necessary and important end products. These include the sulfur-containing amino acids taurine and cysteine, and the neurotransmitters norepinephrine and dopamine. An optimally functioning homocysteine pathway provides methyl and sulfur groups for biochemical reactions, such as detoxification, healthy immune function, ideal joint and cartilage structure, and brain and cardiovascular health.*
Suggested Use / Directions:
Take 2 capsules per day with meals or as directed by your health-care practitioner.

Serving Size:
2 capsules

Amount Per Serving:
Riboflavin (as Riboflavin-5-Phosphate)...30 mg
Vitamin B-6 (as Pyridoxal-5-Phosphate)...10 mg
Folate (as Quatrefolic® [6S]-5-methyltetrahydrofolate, glucosamine salt)...3400 mcg DFE
Vitamin B-12 (as Methylcobalamin [MecobalActive®])...1000 mcg
Trimethylglycine (TMG)...900 mg
L-serine...100 mg

Other Ingredients:
Cellulose (capsule), microcrystalline cellulose, ascorbyl palmitate, dicalcium phosphate, silicon dioxide.

GLUTEN-FREE, DAIRY FREE, SOY FREE, VEGETARIAN, NON-GMO

Keep out of reach of children.

Why is this a top pick for Methylation support?

This product has been chosen as a Top Pick by Fullscript based on factors like quality, ingredients, value, and availability. Your provider’s recommendation always comes first.

This product was selected based on the factors below: Provides activated B vitamins—B2 (riboflavin-5-phosphate), B6 (pyridoxal-5-phosphate), B9 (Quatrefolic® 5-MTHF), and B12 (methylcobalamin)—along with Trimethylglycine (TMG) and L-serine to support methylation and homocysteine metabolism. Ingredients: Vitamin B9 sourced from patented Quatrefolic® 5-methyltetrahydrofolate. Vitamin B12 source is methylcobalamin as MecobalActive® ingredient. Manufactured in a cGMP facility and third party tested for potency and purity.*

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About enhanced testing

Every product on Fullscript meets our high quality standards – but we don’t stop there. Enhanced Testing means select products are pulled directly from Fullscript’s shelves and tested by independent labs, so what’s on the label matches what’s in the product.

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Top pick

Enhanced testing

Homocysteine Supreme

Designs for Health

$31.99