Over a decade of rigorous clinical studies in Europe and elsewhere have established SAM-e (S-adenosyl-L-methionine, an essential methylation and transulfuration cofactor) as a useful tool for supporting normal mood regulation, and joint and liver health. SAM-e increases cell membrane fluidity, up-regulates neurotransmitter receptor number, and supports neurotransmitter receptor affinity. SAM-e supports healthy joints both by helping increase the number of articular chondrocytes and by stimulating the synthesis of sulfated proteoglycans therein.*

SAM-e also protects synovial cells and helps block enzymes that degrade cartilage. SAM-e is a precursor of the critical antioxidant glutathione, a key molecule in the detoxification process in the liver. SAM-e Plus contains the tosylate form of SAM-e as used extensively in clinical trials, and includes several other ingredients found in studies to support and facilitate these functions.* SAM-e Plus tablets are enterically-coated, essential for preventing demethylation in the stomach.

Suggested Use / Directions:

two to four capsules daily, or as directed by your health care practitioner.

Serving Size:
2 Capsules

Amount Per Serving:

B3 (niacinamide) ... 30 mg
B6 (pyridoxine HCl) ... 2 mg
Folic Acid ... 400 mcg
B12 (cyanocobalamin) ... 20 mcg
SAM-e (tosylate disulfate) ... 400 mg
Choline (bitartrate) ... 50 mg

Other Ingredients:
vegetarian capsule (hypromellose and water), silica, magnesium stearate.


Keep in a cool, dry place, tightly capped.