Adipromin Weight, Metabolism, and Heart Complex

A novel, synergistic blend of herbs Moringa oleifera (drumstick tree), Murraya koenigii (curry leaf), and Curcuma longa (turmeric) extracts, clinically demonstrated to support healthy weight loss and a reduction in Visceral Adiposity without added stimulants.  Adipromin is widely used in conjunction with a healthy diet and wellness programs and in conjunction with existing Practitioner weightloss protocols.

Adipromin Weight Management Complex is a unique, evidence-based botanical herbal formula developed to help people manage weight safely and effectively, with fast results, when used in combination with 30 minutes of exercise 5 days a week, and a reduced-calorie diet of 1,800 calories.* Adipromin has been shown to affect not only body weight and BMI, but also lean body mass, blood lipids, and underlying biochemical mediators—such as adiponectin—that control visceral adiposity, glucose regulation, insulin sensitivity, inflammation metabolism, lipid metabolism, and more.* The improvements in waist circumference, triglycerides, and HDL seen in the clinical trials correlate to an improved Visceral Adiposity Index (VAI), a key indicator of cardiometabolic risk.

Adipromin is not a stimulant or appetite suppressant. It does not interfere with absorption of fat or sugar, nor does it create a sense of fullness. Preclinical research indicates a dual mode of action:
•  Modulation of adipogenesis and lipolysis. Adipromin has been shown in preclinical research to inhibit lipid accumulation in adipocytes, slowing differentiation and maturation of adipocytes, and reducing intracellular triglyceride content.1 These actions are thought to be due to the demonstrated down-regulation of transcription factors PPAR‐gamma and C/EBP. †* 
•  Increases Resting Energy Expenditure (REE). Adipromin has been shown in two preclinical animal studies†2,3 and one human clinical trial4 to increase resting energy expenditure.* The underlying mechanisms driving this increased metabolic activity have been elucidated and include notable increases in the production level of thermogenic markers (AMPKα, PGC1α and UCP1) and lipolytic (HSL) proteins.†


CLINICAL EFFICACY
The clinical efficacy of Adipromin for weight loss has been demonstrated in two randomized, double-blind, placebo-controlled clinical trials (RCTs), published in well-respected medical journals.*5,6 

The exemplary second RCT of Adipromin—published in a top-tier medical journal—was conducted in healthy overweight subjects (n=140).6 The 16-week study compared the use of Adipromin in conjunction with an 1800 kcal/day diet and walking plan (30 min 5 times per week) to a placebo with the same diet and walking plan.

Dixit K, et al. Efficacy of a novel herbal formulation for weight loss demonstrated in a 16-week randomized, double-blind, placebo-controlled clinical trial with healthy overweight adults. Diabetes Obes Metab. 2018;20(11):2633-2641. 

•    At the end of the study, subjects taking Adipromin showed significant reductions in body weight (-11.82 pounds vs. -1.92 pounds; p < 0.0001) and BMI (2.05 kg vs. 0.34 kg/m2; p < 0.0001), compared with placebo.*
•    Subjects taking Adipromin had significant reductions in waist circumference (-2.12 inches vs. -0.67 inches; p < 0.0001) and hip circumference (-1.77 inches vs. -0.47 inches p < 0.0001) compared with placebo.*
•    Subjects taking Adipromin had statistically significant improvement compared to placebo in their blood lipid profiles (p < 0.0001), including triglycerides.*
•    Subjects taking Adipromin had improved serum adiponectin (p = 0.0071) and serum ghrelin (p = 0.0568) compared to those taking placebo.*
•    Post-hoc analysis showed that subjects taking Adipromin had a more than 37% reduction in their Visceral Adiposity Index (VAI), whereas the VAI of those taking placebo increased slightly.

A third RCT, to be published in 2022, evaluated the impact of Adipromin on Resting Metabolic Rate (RMR) in healthy overweight subjects (n=60).4 By the end of the 7-day study, Adipromin supplementation had produced a significant increase in RMR compared to placebo (up to 15.2% higher), but with no stimulant effects, i.e., heart rate and blood pressure remained normal.* In fact, subjects felt better while burning more calories, as evidenced by a statistically significant improvement in their Profile of Mood States (POMS) scores compared to placebo.*

No other ingredient provides a comparable set of holistic benefits for weight management and cardiometabolic health: 
•    Fast results
           o         Significant weight loss in 14 days*
           o         Increased calorie burning in just 60 minutes*
•    Support for long-term weight loss (steady results over a 4-month study)*
•    Weight and inches reduction in both women and men* 
•    Targets fat while improving lean body mass*
•    Significantly improved serum lipid profile*
•    Improved biomarkers and beneficial impact on key metabolic proteins that govern adipogenesis, lipolysis, and the browning of white adipose tissue.*


†These mechanisms of action for Adipromin were demonstrated in pre-clinical research, not in humans.

 

Suggested Use:
As a dietary supplement, take 2 capsules per day.

Serving Size: 1 Capsule

Amount Per Serving
ADIPROMIN Patented Blend ... 450mg
Morninga (Moringa oleifera - Drumstick Tree) leaf extract, Curry (Murraya koenigii -curry leaf) leaf extract, Turmeric (Curcuma longa) root extracts
-clinically demonstrated to support healthy weight loss in conjunction with a healthy diet and exercise program.

Other Ingredients: Vegetarian capsule (hydroxypropyl methylcellulose), Leucine

Does Not Contain: Gluten, Soy, Dairy, Lactose, Peanuts, Corn, Wheat, Yeast

Ideal for Vegans, Vegetarians

Trademark™-  Adipromin™

 

Adipromin has been shown in preclinical7 and clinical4,5,6 studies to be safe and well-tolerated.

Warning: If pregnant or nursing consult your healthcare professional prior to use.

REFERENCES
1.    Sengupta K, Golakoti T, Chirravuri V, Marasetti A. An Herbal Formula LI85008F Inhibits Lipogenesis in 3T3‐L1 Adipocytes. Food Nutr Sci 2011;2(8):809‐817.
2.    Kundimi S, Kavungala KC, Sinha S, Tayi VNR, Kundurthi NR, Golakoti T, Davis B, Sengupta K. Combined extracts of Moringa oleifera, Murraya koeingii leaves, and Curcuma longa rhizome increases energy expenditure and controls obesity in high‐fat diet‐fed rats. Lipids Health Dis. 2020 Aug 28;19(1):198.
3.    Choi HJ, Kim HY, Park KS. Antiobesity Effect of a Novel Herbal Formulation LI85008F in High-Fat Diet-Induced Obese Mice. Evid Based Complement Alternat Med. 2021;2021:6612996.
4.    Rao AV, Azad AK. A randomized, double-blind, placebo-controlled clinical study to evaluate the effect of LI85008F on the resting metabolic rate (RMR) of overweight subjects. [Publication TBD]
5.    Sengupta K, Mishra AT, Rao MK, Sarma KV, Krishnaraju AV, Trimurtulu G. Efficacy and tolerability of a novel herbal formulation for weight management in obese subjects: a randomized double blind placebo controlled clinical study. Lipids Health Dis. 2012 Sep 20;11:122.
6.    Dixit K, Kamath DV, Alluri KV, Davis BA. Efficacy of a novel herbal formulation for weight loss demonstrated in a 16‐week randomized, double‐blind, placebo‐controlled clinical trial with healthy overweight adults. Diabetes Obes Metab. 2018 Nov;20(11):2633‐2641.
7.    Krishnaraju AV, Sundararaju D, Srinivas P, Rao CV, Sengupta K, Trimurtulu G. Safety and toxicological evaluation of a novel anti‐obesity formulation LI85008F in animals. Toxicol Mech Methods. 2010 Feb;20(2):59‐68.