Kavinace Ultra PM

Blend of ingredients shown to improve onset and quality of sleep*
Kavinace Ultra PM provides the strongest sleep support among Kavinace products**

GABA is the primary inhibitory neurotransmitter in the brain, which means it plays a central role in balancing the excitability of neurons (1). Because of this reason, GABA is important for promoting sleep, calm, and managing stress (2-4). Stress is thought to alter GABA synthesis and activity by affecting the expression of GABA-synthesizing enzymes and receptors (5).

The effects of Kavinace Ultra PM have been studied in a randomized, placebo-controlled study.
One capsule of Kavinace Ultra PM taken at bedtime for 5 days significantly improved quality of sleep as measured by the Pittsburgh Sleep Quality Index (6).* Participants taking Kavinace Ultra PM reported decreased time to fall asleep, increased duration of sleep, and decreased sleep disturbances (6).*

**Relative amounts of ingredients as compared to other NeuroScience Kavinace products.

References:

1. Gou Z, et al. Dongwuxue Yanjiu. 2012;33(E5-6):E75-81.
2. Mohler H. Neuropharmacology. 2012;62(1):42-53.
3. Saper C, et al. Nature. 2005;437(7063):1257-63.
4. Mody I and Maguire J. Front Cell Neurosci. 2012;6:4.
5. Maguire J. Front Cell Neurosci. 2014;8:157.
6. Data on file, 2011. NeuroScience, Inc., Osceola, WI 54020.

Take 1 capsule at bedtime as needed or as directed by your healthcare provider.

Serving Size: 1 Capsule

Amount Per Serving
Melatonin ... 3mg
Proprietary Blend ... 650mg
4-amino-3-phenylbutyric acid, 5-hydroxytryptophan (from
Griffonia simplicifolia seed extract)

Other Ingredients: Vegetable capsule ((Hypromellose, water), Microcrystalline Cellulose, and Magnesium Stearate (vegetable source).

If you are pregnant or nursing, consult your healthcare practitioner before use.