Methylation is key to keeping homocysteine levels in check, as well as for facilitating multiple biochemical processes involving neurotransmitter synthesis, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. Maintaining a desirable level of homocysteine in the blood has joined healthy cholesterol and triglyceride levels as leading biomarkers for the maintenance of good cardiovascular health.* Preventing an undesirable homocysteine level is also associated with the maintenance of bone, female reproductive, cognitive, and neurological health.* Methyl-Guard Plus supports methylation and promotes healthy homocysteine levels with betaine (trimethylglycine), 5-MTHF (the active form of folate), riboflavin 5'-phosphate (the active form of vitamin B2), pyridoxal 5'-phosphate (the active form of vitamin B6), and methylcobalamin (an active form of vitamin B12).*
Various conditions and stressors can have an adverse impact on the body’s methylation cycle. For example, nutrient deficiencies and environmental and physical stressors can cause inefficient methylation. In addition, a common human genetic mutation that restricts the activity of a key enzyme in the body involved in methylation affects approximately 60 percent of U.S. adults. This genetic anomaly poses a significant challenge to efficient methylation – and creates an important need for nutritional support to help rectify it.
Methylation – the addition of a methyl group (one carbon atom attached to three hydrogen atoms) to another molecule – is an essential and vital biochemical process that is involved in multiple biochemical pathways involving neurotransmitter synthesis, detoxification, cardiovascular health, eye health, muscle health, bone health, and redox balance. A number of specific nutrients are necessary for methylation processes to occur normally.* Maintaining a normal homocysteine level in the blood is important for good cognitive health.* A deficiency in the cofactors that metabolize homocysteine is commonly observed in the elderly, which results in increasing homocysteine levels with advancing age. These elevated levels of homocysteine associated with aging, as well as low levels of folic acid and vitamins B6 and B12, can result in the decreased methylation of numerous substances, including DNA and proteins, which can diminish the integrity of vascular structures and neurons.* Therefore, providing nutritional cofactors for homocysteine metabolism provides support for a healthy brain.*
A number of biochemical imbalances that can raise homocysteine levels can be addressed by supplementing with the appropriate nutrient cofactors.* These include folic acid (as L-5-methyltetrahydrofolate), vitamin B12 (as methylcobalamin), and betaine (trimethylglycine), which promote the recycling of homocysteine to the amino acid methionine. In addition, the breakdown of homocysteine into beneficial amino acids cysteine and taurine can be facilitated by pyridoxal 5'-phosphate (the active form of vitamin B6).* Studies have shown these nutrients help maintain normal homocysteine levels in the blood.*
Serving Size: 3 Capsules
Amount Per Serving
Betaine Anhydrous ... 1.8g
Folate ... 5mg DFE
Vitamin B12 ... 3mg
Vitamin B2 ... 90mg
(Riboflavin 5'-Phosphate Sodium)
Vitamin B6 ... 45mg
Other Ingredients: Calcium (Citrate), Calcium Laurate, Hypromellose Capsule
This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients.
If pregnant, consult your health professional before using this product.
5-methyltetrahydrofolate (5-MTHF) supplementation is not recommended concurrently with methotrexate cancer therapy, as it can interfere with methotrexate's anti-neoplastic activity; however, 5-MTHF has not been shown to interfere with the anti-inflammatory activity of methotrexate. An individual taking methotrexate for psoriasis or rheumatoid arthritis can safely take a supplement containing folate.