Celiac, IBS, and Crohn's Assay (CICA)
Cell Science Systems
Sample type: Serum, Whole blood
Requires fasting: No
Phlebotomy is required for this test
Details
The Celiac, IBS, and Crohn's Assay (CICA) evaluates genetic and serological markers for celiac disease and Crohn's disease.
- Tissue Transglutaminase (tTG) Antibody (IgA)
- Immunoglobulin A (IgA)
- Deamidated gliadin peptide (DGP) IgA
- Deamidated gliadin peptide (DGP) IgG
- Tissue Transglutaminase (tTG) Antibody (IgG)
- Saccharomyces cerevisiae IgG
- ATG16L1 (T300A)
- HLA-DQA1*03
- HLA-DQA1*05
- HLA-DQB1*02
- HLA-DQB1*03:02
- NOD2 (G908R)
- NOD2 (L1007fsinsC)
- NOD2 (R702W)
- Saccharomyces cerevisiae IgA
Estimated days for results: Results should arrive 10 business days after the lab receives samples.
The Celiac, IBS, and Crohn's Assay (CICA) is a comprehensive test array that analyzes genetic predisposition, detects specific antibodies, and measures potentially inflammatory cellular reactions all through one simple blood draw. Celiac disease risk analysis is determined based on the presence or absence of the HLA-DQ genotypes. Both the DQ8 and DQ2.5 genotypes are tested in this array, with the DQ2.5 genotypes representing a much greater risk of celiac disease. Four specific serum antibodies (DGP IgG/IgA and tTG IgG/IgA) are tested due to their high sensitivity and specificity for active celiac disease. The higher the antibody levels, the more likely untreated celiac disease is present. Genetic markers, mutations in the ATG16L1 and NOD2 genes, associated with the Crohn’s disease are tested along with serologic markers for complete assessment. Anti-Saccharomyces Cerevisiae Antibody (ASCA; IgG/IgA) are immune proteins that are frequently present in people who have Crohn’s disease. The presence of ASCA may also reflect increased intestinal inflammation and permeability, including an association with active Crohn’s disease.
10 business days
- Please read the provided test collection instructions.
- Sample collection must be performed by a phlebotomist.
- If you are taking anti-inflammatory medications or anti-rejection therapy, consult your healthcare provider regarding your medication usage before the test. Certain medications may affect test results.
- DO NOT discontinue any prescription medication without consulting your healthcare provider.
Day of Collection
- DO NOT take any medications or supplements for 3-4 hours before your blood draw.
- If your blood draw is scheduled in the morning, take your morning medications and supplements after your blood draw.
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
