Beta-glucuronidase
Doctor's Data
Sample type: Stool
Requires fasting: No
At home test
Details
Beta-glucuronidase is an enzyme that breaks the tight bond between glucuronic acid and toxins in the intestines. The binding of toxins in the gut is protective by way of blocking their absorption and facilitating excretion. Higher levels of beta-glucuronidase may be associated with an imbalanced intestinal microbiota profile, as well as higher circulating estrogens and lower fecal excretion of estrogens in premenopausal women.
- Beta-Glucuronidase
Estimated days for results: Results should arrive 4 to 6 days after the lab receives samples.
β-glucuronidase (β-G) is an enzyme that breaks the tight bond between glucuronic acid and toxins in the intestines. The liver and intestine bind toxins, steroid hormones and some dietary components to glucuronic acid. That is a protective process that limits absorption and enterohepatic resorption of toxins, and enhances excretion.
A high level of activity of β-G in the gut is not desirable. A low level of β-G activity is not known to be of any direct clinical consequence. β -glucuronidase is produced by the intestinal epithelium and certain intestinal bacteria.
Observational studies have indicated a correlation between high β-G activity and certain cancers, but a definitive causal relationship has not been established. Higher levels of β-G have been associated with higher circulating estrogens and lower fecal excretion of estrogens in premenopausal women.
A potential dietary carcinogen derived from cooked meat and fish induces high β-G activity and prolongs internal exposure to the toxin in an experimental animal model. Diet and intestinal bacterial imbalance modulate β-G activity. High fat, high protein and low fiber diets are associated with higher β-G activity compared to vegetarian or high soluble fiber diets.
Higher β-G may be associated with an imbalanced intestinal microbiota profile. Some major bacterial producers of fecal β-G include Bifidobacterium, Lactobacillus, Escherichia coli, Clostridium, Bacteroides fragilis and other Bacteroides species, Ruminococcus gnavus, and species that belong to the genera Staphylococcus and Eubacterium. Low β-G activity is an indicator of abnormal metabolic activity among the intestinal microbiota that may be influenced by dietary extremes, diminished abundance and diversity of the intestinal microbiota, or heavy probiotic and/or prebiotic supplementation.
A low fat, low meat and high fiber diet, such as consumed by strict vegetarians, may be associated with lower β-G activity compared to a typical “Western diet.” High-end consumption of soluble fiber (e.g. inulin) and supplementation with Lactobacillus acidophilus may be inconsequentially associated with lower fecal β-G. β-glucuronidase (β-G) is an enzyme that breaks the tight bond between glucuronic acid and toxins in the intestines. The liver and intestine bind toxins, steroid hormones and some dietary components to glucuronic acid. That is a protective process that limits absorption and enterohepatic resorption of toxins, and enhances excretion.
A high level of activity of β-G in the gut is not desirable. A low level of β-G activity is not known to be of any direct clinical consequence. β -glucuronidase is produced by the intestinal epithelium and certain intestinal bacteria.
Observational studies have indicated a correlation between high β-G activity and certain cancers, but a definitive causal relationship has not been established. Higher levels of β-G have been associated with higher circulating estrogens and lower fecal excretion of estrogens in premenopausal women.
A potential dietary carcinogen derived from cooked meat and fish induces high β-G activity and prolongs internal exposure to the toxin in an experimental animal model. Diet and intestinal bacterial imbalance modulate β-G activity. High fat, high protein and low fiber diets are associated with higher β-G activity compared to vegetarian or high soluble fiber diets.
Higher β-G may be associated with an imbalanced intestinal microbiota profile. Some major bacterial producers of fecal β-G include Bifidobacterium, Lactobacillus, Escherichia coli, Clostridium, Bacteroides fragilis and other Bacteroides species, Ruminococcus gnavus, and species that belong to the genera Staphylococcus and Eubacterium. Low β-G activity is an indicator of abnormal metabolic activity among the intestinal microbiota that may be influenced by dietary extremes, diminished abundance and diversity of the intestinal microbiota, or heavy probiotic and/or prebiotic supplementation.
A low fat, low meat and high fiber diet, such as consumed by strict vegetarians, may be associated with lower β-G activity compared to a typical “Western diet.” High-end consumption of soluble fiber (e.g. inulin) and supplementation with Lactobacillus acidophilus may be inconsequentially associated with lower fecal β-G. β-glucuronidase (β-G) is an enzyme that breaks the tight bond between glucuronic acid and toxins in the intestines. The liver and intestine bind toxins, steroid hormones and some dietary components to glucuronic acid. That is a protective process that limits absorption and enterohepatic resorption of toxins, and enhances excretion.
4–6 business days
- Add-on: Calprotectin
- Add-on: Elastase
- Add-on: H. Pylori Antigen
- Add-on: Lactoferrin
- Add-on: Lysozyme
- Add-on: Secretory IgA
- Add-on: Zonulin Family Protein
Please read all of the directions, and familiarize yourself with the collection
procedures.
If you are taking antifungal or antibiotic medications, please
finish the course of medication, and then wait three days before starting this
collection.
Please refrain from taking digestive enzymes, antacids, and aspirin
for two days prior to and during the specimen collection, unless otherwise
instructed by your physician.
Never discontinue prescription medications without first consulting your physician.
procedures.
If you are taking antifungal or antibiotic medications, please
finish the course of medication, and then wait three days before starting this
collection.
Please refrain from taking digestive enzymes, antacids, and aspirin
for two days prior to and during the specimen collection, unless otherwise
instructed by your physician.
Never discontinue prescription medications without first consulting your physician.
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
