Cardiovascular Risk Profile
Doctor's Data
Sample type: Serum
Requires fasting: Yes
Phlebotomy is required for this test
Details
Cardiovascular disease (CVD) is associated with more deaths than all cancers—and more deaths in women than breast cancer. This Cardiovascular Risk Profile evaluates a thorough battery of traditional and advanced biomarkers to aid in early detection and modification of risk factors. Doctor's Data measures the activity of lipoprotein-associated phospholipase-A2 (PLAC®), as well as the true LDL culprits; oxidized LDL, small dense LDL and Lp(a), which are higher in CVD patients and correlated with the severity of CVD. A total of thirteen primary and secondary risk factors are evaluated to provide actionable information at a tremendous value.
- Small Dense LDL
- hsCRP
- Apolipoprotein B
- Homocysteine
- High-Density Lipoprotein Cholesterol
- Triglycerides
- Total Cholesterol
- Non-HDL Cholesterol
- VLDL Cholesterol
- OxLDL
- Apolipoprotein A-1, Blood
- Lipoprotein (a), Blood
- Low-Density Lipoprotein Cholesterol
- Lp-PLA2 Activity
Estimated days for results: Results should arrive 5 to 7 days after the lab receives samples.
Total and LDL cholesterol, total triglycerides and HDL cholesterol have traditionally been measured to gauge CVD risk. However, recent research indicates that more focused biomarkers can provide even greater insight.
For example, oxidized LDL is plaque-specific and directly involved in accelerated atherogenesis and late-stage atherosclerotic plaque instability and rupture. Small dense LDL exhibits greater penetration into the arterial wall and has a longer half-life as well as lower resistance to oxidation compared to that of large buoyant LDL. Circulating levels of these two markers are:
1. Strong independent CVD risk factors
2. Higher in CVD patients
3. Correlated with the severity of CVD
4. Not correlated with LDL cholesterol levels
In addition, levels of apolipoproteins A-1 and B, specific protein constituents of HDL and LDL, are also strong indicators of risk.
Doctor's Data profiles evaluate each of these biomarkers as well as ratios of atherogenic to anti-atherogenic lipids, lipoproteins and apolipoproteins for further insight.
Inflammation
Arterial damage is associated with the infiltration of white cells into vessel walls and inflammation, which increases blood levels of two acute phase proteins, C-reactive protein and ferritin. For example, patients with moderately elevated CRP are more likely to develop stroke, myocardial infarction and severe peripheral arterial disease. Although not specific to CVD, analysis of high sensitivity to these two proteins is valuable in a comprehensive assessment of CVD risk.
5–7 business days
- Add-on: Serum Elements
- Add-on: Zonulin Family Protein
This test requires a single blood collection that is drawn before breakfast after an overnight (6 hour minimum) fast. Non-Fasting collections can cause deviations in patient results.
There are no special dietary requirements for this test unless otherwise instructed by your physician.
Never discontinue prescription medications without first consulting your physician.
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
