Comprehensive Clostridium Culture
Doctor's Data
Sample type: Stool
Requires fasting: No
At home test
Details
To aid in the identification and differentiation of Clostridium species, our specialized anaerobic culture optimized for Clostridium detects nearly 40 beneficial and pathogenic species, including C. botulinum, C. tetani and C. perfringens, as well as C. difficile, which is often present in healthy individuals, but can be associated with antibiotic-associated diarrhea. If C. difficile is cultured at any level, the sample is automatically tested for all known toxigenic strains using an FDA-cleared, molecular diagnostic DNA assay at no additional charge.
- Comprehensive clostridium culture
Estimated days for results: Results should arrive 14 to 21 days after the lab receives samples.
To aid in the identification and differentiation of Clostridium species, our specialized anaerobic culture optimized for Clostridium detects nearly 40 beneficial and pathogenic species, including C. botulinum, C. tetani and C. perfringens, as well as C. difficile, which is often present in healthy individuals, but can be associated with antibiotic-associated diarrhea.
If C. difficile is cultured at any level, the sample is automatically tested for all known toxigenic strains using an FDA-cleared, molecular diagnostic DNA assay at no additional charge.
Useful for:
Antibiotic-Associated Diarrhea
Autism Spectrum Disorders
Clostridium is a diverse genus of bacteria, many of which are abundant and normal inhabitants of the human gastrointestinal tract (GIT).
Many of the Clostridium species can have beneficial effects on the metabolism and health of the GIT in part by breakdown of polysaccharides, saccharolytic fermentation of carbohydrates to short chain fatty acids, and regulation of immune function. While non-pathogenic Clostridium species are predominantly saccharolytic, toxin-producing species tend to be strongly proteolytic.
Proteolytic fermentation produces toxic metabolites such as ammonia, amines, volatile phenols and indoles which are pharmacologically active and affect a variety of physiological functions including adverse effects in the central nervous system. Aside from the well-established pathogenic Clostridium species such as C. botulinum, C. tetani, C. perfringens and C. difficile, other species may have yet-to-be-elucidated roles in health and disease. For example, they may be involved as mediators in the gut-brain connection in the evolution of psychiatric neurodevelopmental delay such as autism and autism spectrum disorders.
Clostridium species that produce neurotoxins and potentially toxic metabolic byproducts have been reported to be more prevalent in autistic children compared to neurotypical controls most notable were greater quantities of C. bolteae and members of the C. hystolyticum group.
Clostridia are anaerobic Gram-positive bacteria that do not grow in the more aerobic environment of the distal colon. However Clostridia produce extremely durable endospores as a means of proliferation. The spores are resistant to air, antibiotics, heat, drying and disinfectants. Doctor's Data uses growth media optimally suited for growth of Clostridium species and anaerobic culture conditions to germinate the spores to metabolically active bacteria that are sub-cultured for positive identification (speciation).
If C. difficile is cultured at any level, the sample is automatically tested for all known toxigenic strains using an FDA-cleared, molecular diagnostic DNA assay at no additional charge. Clostridia generally are resistant to antibiotics and treatment of an overgrowth of C. difficile, especially in asymptomatic carriers and infants under age two, is usually not warranted. Additionally, since plasmids have a potential role in transferring various capacities, including antibiotic resistance, from one organism to another, the use of antibiotics in the treatment of clostridia overgrowth should be considered carefully.
If C. difficile is cultured at any level, the sample is automatically tested for all known toxigenic strains using an FDA-cleared, molecular diagnostic DNA assay at no additional charge.
Useful for:
Antibiotic-Associated Diarrhea
Autism Spectrum Disorders
Clostridium is a diverse genus of bacteria, many of which are abundant and normal inhabitants of the human gastrointestinal tract (GIT).
Many of the Clostridium species can have beneficial effects on the metabolism and health of the GIT in part by breakdown of polysaccharides, saccharolytic fermentation of carbohydrates to short chain fatty acids, and regulation of immune function. While non-pathogenic Clostridium species are predominantly saccharolytic, toxin-producing species tend to be strongly proteolytic.
Proteolytic fermentation produces toxic metabolites such as ammonia, amines, volatile phenols and indoles which are pharmacologically active and affect a variety of physiological functions including adverse effects in the central nervous system. Aside from the well-established pathogenic Clostridium species such as C. botulinum, C. tetani, C. perfringens and C. difficile, other species may have yet-to-be-elucidated roles in health and disease. For example, they may be involved as mediators in the gut-brain connection in the evolution of psychiatric neurodevelopmental delay such as autism and autism spectrum disorders.
Clostridium species that produce neurotoxins and potentially toxic metabolic byproducts have been reported to be more prevalent in autistic children compared to neurotypical controls most notable were greater quantities of C. bolteae and members of the C. hystolyticum group.
Clostridia are anaerobic Gram-positive bacteria that do not grow in the more aerobic environment of the distal colon. However Clostridia produce extremely durable endospores as a means of proliferation. The spores are resistant to air, antibiotics, heat, drying and disinfectants. Doctor's Data uses growth media optimally suited for growth of Clostridium species and anaerobic culture conditions to germinate the spores to metabolically active bacteria that are sub-cultured for positive identification (speciation).
If C. difficile is cultured at any level, the sample is automatically tested for all known toxigenic strains using an FDA-cleared, molecular diagnostic DNA assay at no additional charge. Clostridia generally are resistant to antibiotics and treatment of an overgrowth of C. difficile, especially in asymptomatic carriers and infants under age two, is usually not warranted. Additionally, since plasmids have a potential role in transferring various capacities, including antibiotic resistance, from one organism to another, the use of antibiotics in the treatment of clostridia overgrowth should be considered carefully.
14–21 business days
- Add-on: Bacteriology Culture
- Add-on: Yeast Culture
Please read all of the directions, and familiarize yourself with the collection
procedures.
If you are taking antifungal or antibiotic medications, please
finish the course of medication, and then wait three days before starting this
collection.
Please refrain from taking digestive enzymes, antacids, and aspirin
for two days prior to and during the specimen collection, unless otherwise
instructed by your physician.
Refrain from taking probiotic supplements for
two weeks prior to specimen collection unless instructed otherwise by your
physician.
Never discontinue prescription medications without first consulting your physician.
procedures.
If you are taking antifungal or antibiotic medications, please
finish the course of medication, and then wait three days before starting this
collection.
Please refrain from taking digestive enzymes, antacids, and aspirin
for two days prior to and during the specimen collection, unless otherwise
instructed by your physician.
Refrain from taking probiotic supplements for
two weeks prior to specimen collection unless instructed otherwise by your
physician.
Never discontinue prescription medications without first consulting your physician.
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
