Fullscript logoThe Fullscript green leaf logo alongside the text FullscriptFullscript leaf logo
Lab companiesSign in
Create account
Doctor's Data

Comprehensive Hormone Profile

Doctor's Data

Sample type: Saliva

Requires fasting: No

At home test


Details

The Comprehensive Hormone Profile is the best option for baseline testing of male or female hormonal status. This non-invasive test requires only 2cc per vial of saliva in 4 separate collections. Sex hormones are tested, as well as 4 cortisol levels to evaluate the diurnal cortisol pattern. This test is a consideration in men and women concerned with changing hormone levels as a result of age, cycling women experiencing PMS, peri- and post-menopausal women concerned with their estradiol and progesterone levels for replacement considerations, and anyone with symptoms involving fatigue, insomnia, stress, immunity problems, blood sugar problems, and obesity.


  • Cortisol Evening
  • Cortisol Night
  • Cortisol Noon
  • Cortisol Morning - AM30
  • Testosterone
  • Estradiol, Saliva
  • Progesterone, Saliva

Estimated days for results: Results should arrive 3 to 5 days after the lab receives samples.

The Comprehensive Hormone Profile reports hormone levels, and also calculates the Progesterone (Pg)/Estradiol (E2) ratio, which assesses the relationship between estradiol, which can drive cellular proliferation, and progesterone, which mitigates that growth and potentiates cellular differentiation. 

Hormones are powerful molecules essential for maintaining physical and mental health. We frequently think of estrogen as being a female hormone, and testosterone as being a male hormone. But men AND women make both, plus several more that need to be in balance for optimum health. An imbalance of any one hormone can throw your physical and mental health out of balance, causing aggravating and even serious health problems. 

One size does not fit all when it comes to hormones. For decades western medicine has prescribed hormone replacement therapy as if everyone needed the same thing and the same amount. Nothing could be further from the truth. Your hormones are like your fingerprints and in order to achieve optimal health, you need to know what your specific imbalances are. Female and male hormone tests can help identify these imbalances. 

There are several ways to test for hormones (saliva, serum and urine). Saliva is the best method to test the active/bioavailable portion of hormones, which are reflective of tissue levels. If your patient is seeking bio-identical hormone replacement (BHRT), you'll need to know active hormone levels. In addition, if using a topical (transdermal) hormone preparation for treatment, saliva testing is the most accurate tool to measure and monitor hormone status. 

Useful for: 

Women Experiencing: 
  • Hot flashes 
  • Night sweats 
  • Breast tenderness 
  • Irritability 
  • Forgetfulness 
  • Irregular menstrual cycles 
  • Vaginal dryness 
  • Urinary incontinence 
  • Uterine fibroids 
  • Increased facial/body hair 
  • Acne 

Men Experiencing: 
  • Decreased libido 
  • Erectile dysfunction 
  • Loss of stamina 
  • Decrease in mental sharpness 
  • Reduced muscle size 
  • Increased moodiness 
  • Metabolic syndrome 
  • Prostate enlargement or cancer
  • Hot flashes 
  • Irritability 

Men or Women Experiencing: 
  • Weight gain
  • High blood sugar
  • Elevated lipids (cholesterol and/or triglycerides)
  • Insomnia
  • Fatigue
  • Fibromyalgia
  • Decreased stamina 
  • Anxiety/Depression
  • Chronic disease

3–5 business days


View here

Before You Start
  • Follow the test collection instructions here.
  • If you are a menstruating woman, collect one day during days 19-23 of your menstrual cycle (assuming a 28-day cycle). Day 1 of your cycle is the first day of your period.
  • If you are a man or a non-menstruating woman, collect on any day.

Hormone Use Instructions
  • DO NOT discontinue any prescription medications without first consulting your healthcare provider.
  • Topical hormones:
    • Your last dose before sample collection should be 12-24 hours before collecting your first sample.
    • DO NOT use on the day of saliva collection.
  • Sublingual hormones or troches:
    • Your last dose before sample collection should be 24-36 hours before collecting your first sample.
    • Drink 2 full glasses of water (about 16 oz) after taking your last dose to clean the tissues.
    • DO NOT take on the day of saliva collection.
  • Hormone injections, subcutaneous pellets, or transdermal patches:
    • Collect your samples at the halfway point between doses.
  • Oral hormones (pills):
    • Use as prescribed on the day of collection.

Cortisol or Cortisol-Containing Products
  • If you are taking a cortisol supplement, glucocorticoid, or cortisol-containing medication, consult with your healthcare provider before collecting your samples.
  • It is recommended to stop using these products 5 days before sample collection.

Day of Collection
  • Avoid supplements and non-essential medications. DO NOT discontinue any prescription medications without first consulting your healthcare provider.
  • Avoid caffeine-containing foods and beverages.
  • Avoid anti-aging creams.
  • Avoid the following for 1 hour before collecting each sample: 
    • Eating
    • Drinking
  • Avoid the following for 30 minutes before collecting each sample: 
    • Brushing your teeth
    • Flossing your teeth
    • Having dental work done
  • 10 minutes before each saliva collection, rinse your mouth with water.

Collection Schedule
  • Sample 1: 30 minutes after awakening
  • Sample 2: Before lunch
  • Sample 3: Before dinner
  • Sample 4: Before bed


State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

Provider pricing unlocks when you sign up

Go from test to plan, in one place

  • 2,500+ blood labs & specialty tests from partners you trust, one login

  • Turn results into personalized plans with Fullscript Assist

  • Competitive cash-pay pricing and nationwide phlebotomy

Create free accountBook a demo

Trusted by 50,000+ practitioners

20+

lab companies

Quest DiagnosticsAccess Medical Labs3x4 Genetics

40+

EHR integrations

Practice BetterCerboOptiMantra

Having labs on Fullscript has been a real time saver for my practice. I love the convenience and ability to order affordable labs quickly for my patients. It will be a staple in my workflow going forward.

Joseph Thomas, MD

Verified Fullscript practitioner