Fecal Gluten Peptide (Stand-Alone)

Detect Exposure to Gluten for Better Dietary Management
Gluten Peptide is commonly present in stool. Gluten-containing grains (such as wheat, rye, barley, and oat*) are digested into their gliadin and glutenin subunits. A specific section of the gliadin protein, referred to as the 33-mer peptide, is resistant to digestion in the human gastrointestinal (GI) tract and functions as a significant immune trigger in certain individuals, including those with celiac disease (CD).1 Even in non-celiac gluten-sensitive (NCGS) individuals, the 33-mer protein can be antigenic, inducing food sensitivities and intestinal permeability (leaky gut). When intestinal permeability is present, this antigenic peptide can drive extra-intestinal symptoms – those presenting outside the GI tract – such as skin manifestations, headaches, behavioral symptoms, and more. This test is a direct quantification of the 33-mer gliadin peptide present in stool samples. Because this peptide is highly resistant to human digestion, it can be accurately detected in a person's stool several days after consumption of gluten. The Gluten Peptide (Stool Gluten) marker can be ordered as an add-on to the GI-MAP in the Results Portal.The Benefits of Quantitatively Assessing Gluten in Stool
Currently, the only approach to managing celiac disease is to maintain a strict gluten-free (GF) diet for life. Additionally, as non-celiac gluten-related disorders are emerging more and more in literature and clinical practice, many people choose to be gluten-free to reduce GI inflammation and associated symptoms, and to prevent or heal intestinal permeability. Although conceptually straight forward, there are inherent challenges to following a GF diet as recommended. Estimated compliance rates vary considerably. The importance of monitoring a GF diet is obvious, however there are currently no clear guidelines for exploring adherence or assessing the outcome. Recent studies suggest that patients cannot rely on dietary best practices or even symptoms to understand if they have been exposed to gluten.
The Fecal Gluten Peptide Add-On (Stool Gluten) is an accurate and noninvasive method that enables a direct, quantitative assessment of gluten consumption. The amount of gluten peptide detected in stool rises in proportion to the amount of gluten consumed. Thus, the test can be useful for monitoring occasional exposures or exposures that may be routine in a persons' lifestyle (even if they are unknown).
Fecal gluten monitoring is an important tool to: 

Continue taking all medications unless otherwise directed by your provider.

This test can be taken at any time.

No special preparation or timing is required.

DO NOT discard the pink liquid in the specimen vial.

DO NOT freeze your sample.

Save the printed requisition form you received in your Fullscript box and send it back with your sample.

Your sample must be CLEARLY labeled and arrive at the lab with a completed test requisition form for the lab to analyze it.

Your sample can only be shipped Monday - Friday.

Your sample must be received by the lab within 5 days of collection. It is ONLY VIABLE FOR 10 DAYS post-collection.