Methylation Panel
Genova Diagnostics
Sample type: Plasma, Whole blood
Requires fasting: No
Phlebotomy is required for this test
Details
Methylation is a chemical process within cells that can be linked to mood regulation, hormone detoxification, energy production, and healthy aging. Vitamins, minerals, and amino acids from the diet are needed to keep the methylation process running smoothly. This comprehensive panel provides an assessment of methylation and transsulfuration markers. Methylation Panel results are delivered via easy-to-interpret graphics, summarizing this complex biochemistry into clear and actionable information.
- Betaine
- Taurine
- Sarcosine
- Methionine
- Glycine
- Choline
- Serine
- Glutathione
- Cystathionine
- Cysteine
- Homocysteine
Estimated days for results: Results should arrive 14 business days after the lab receives samples.
Why choose Genova Diagnostics' Nutritional Products?
Genova’s Methylation Panel combines phenotypic and genotypic information in one profile. Complex biochemistry is summarized with easy-to-interpret graphics. The most comprehensive methylation assessment available – includes methylation and transsulfuration markers, as well as multiple genetic SNPs to provide a more complete assessment.
A Personalized Approach to Healthy Aging
The Methylation Panel is an innovative test designed to offer insight into the critical biochemical methylation pathway. Methylation metabolites are measured in plasma, and genetic single nucleotide polymorphisms (SNPs) are analyzed via buccal swab.
Patient results are synthesized on a front-page Interpretation-at-a-Glance (IAAG) graphic for quick methylation status assessment. Within the report, results are shown in a methylation pathway graphic to provide a clear understanding of the biochemistry involved.
What is Methylation?
Methylation is a chemical process that happens billions of times per second in every cell of the body. Methyl groups are transferred and donated between many different molecules which change their structure and function. Methyl groups act like billions of switches which turn genes on or off, help regulate mood, detoxify hormones, produce energy, and promote healthy aging. Vitamins, minerals, and amino acids from the diet are needed to keep this process running smoothly. There are also genetic factors and oxidative stressors which can affect how well this pathway works.
Why is Methylation important?
Methylation is needed to create DNA and RNA and regulate gene expression. It helps make creatine, which is needed for skeletal muscle contraction. Methylation is involved in basic energy production, fat metabolism, immune responses, vascular health, and cell membrane repair. It produces and metabolizes neurotransmitters to regulate mood. Methylation also works to neutralize toxins and hormones.
Which patients can benefit from the Methylation Panel?
Because of its all-encompassing role in basic human physiology, the range of symptoms associated with methylation defects is broad. The Methylation Panel can offer insight in patients with:
Genova’s Methylation Panel combines phenotypic and genotypic information in one profile. Complex biochemistry is summarized with easy-to-interpret graphics. The most comprehensive methylation assessment available – includes methylation and transsulfuration markers, as well as multiple genetic SNPs to provide a more complete assessment.
A Personalized Approach to Healthy Aging
The Methylation Panel is an innovative test designed to offer insight into the critical biochemical methylation pathway. Methylation metabolites are measured in plasma, and genetic single nucleotide polymorphisms (SNPs) are analyzed via buccal swab.
Patient results are synthesized on a front-page Interpretation-at-a-Glance (IAAG) graphic for quick methylation status assessment. Within the report, results are shown in a methylation pathway graphic to provide a clear understanding of the biochemistry involved.
What is Methylation?
Methylation is a chemical process that happens billions of times per second in every cell of the body. Methyl groups are transferred and donated between many different molecules which change their structure and function. Methyl groups act like billions of switches which turn genes on or off, help regulate mood, detoxify hormones, produce energy, and promote healthy aging. Vitamins, minerals, and amino acids from the diet are needed to keep this process running smoothly. There are also genetic factors and oxidative stressors which can affect how well this pathway works.
Why is Methylation important?
Methylation is needed to create DNA and RNA and regulate gene expression. It helps make creatine, which is needed for skeletal muscle contraction. Methylation is involved in basic energy production, fat metabolism, immune responses, vascular health, and cell membrane repair. It produces and metabolizes neurotransmitters to regulate mood. Methylation also works to neutralize toxins and hormones.
Which patients can benefit from the Methylation Panel?
Because of its all-encompassing role in basic human physiology, the range of symptoms associated with methylation defects is broad. The Methylation Panel can offer insight in patients with:
- questionable detoxification (patients who take hormone therapy, drink alcohol, or have toxin exposure)
- cancer risk
- cardiovascular disease (non-coronary atherosclerosis, hypertension, coronary artery disease)
- psychiatric and mood disorders (schizophrenia, autism, bipolar disorder, anxiety, depression)
- neurologic disorders (Parkinson’s disease, cognitive decline),
- chronic fatigue
How are the results of the Methylation Panel helpful?
The Methylation Panel can uncover needs for nutritional support such as amino acids, vitamins, and minerals. Knowing this can help guide dietary and nutraceutical treatment plans. Additionally, knowing genetic predispositions can help focus supplementation to override potential methylation defects.
14 business days
- Add-On: Methylation Genomics
Plan Your Collection
Use a calendar to plan your specimen collection.
Ship Monday thru Friday and avoid US holidays which may cause delays.
4 Days before Collection
Check with your clinician whether it is necessary to discontinue medications/ supplements. Some clinicians choose to discontinue non-essential nutritional supplements to get a ‘baseline’ reading.
Some clinicians choose to continue nutritional supplementation to assess the efficacy of their treatments.
Night Before Blood Draw
Fast overnight. Water is okay.
Freeze freezer brick at least 8 hours.
If collecting cheek swab, brushing and flossing are okay but do not use mouthwash.
Morning of Collection
If collecting cheek swab - do not eat, brush or floss your teeth, use mouthwash, chew gum or use any tobacco, or coffee products.
You may drink ONLY water before specimen collection. Collect cheek swab (if ordered) immediately upon waking.
Use a calendar to plan your specimen collection.
Ship Monday thru Friday and avoid US holidays which may cause delays.
4 Days before Collection
Check with your clinician whether it is necessary to discontinue medications/ supplements. Some clinicians choose to discontinue non-essential nutritional supplements to get a ‘baseline’ reading.
Some clinicians choose to continue nutritional supplementation to assess the efficacy of their treatments.
Night Before Blood Draw
Fast overnight. Water is okay.
Freeze freezer brick at least 8 hours.
If collecting cheek swab, brushing and flossing are okay but do not use mouthwash.
Morning of Collection
If collecting cheek swab - do not eat, brush or floss your teeth, use mouthwash, chew gum or use any tobacco, or coffee products.
You may drink ONLY water before specimen collection. Collect cheek swab (if ordered) immediately upon waking.
Minimum age:
2
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
