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Genova Diagnostics

Rhythm Plus + CAR

Genova Diagnostics

Sample type: Saliva

Requires fasting: No

At home test


Details

The Rhythm Plus™ + CAR test provides a comprehensive salivary assessment of estradiol, progesterone, and testosterone that spans a full 28 days. It is designed for premenopausal and perimenopausal women not currently supplementing with hormones. This test includes the Adrenocortex Stress Profile, the Cortisol Awakening Response, and the Comprehensive Melatonin Profile for a more complete hormone analysis.


  • Cortisol Evening
  • Cortisol Night
  • Cortisol Noon
  • Cortisol Morning - AM30
  • Cortisol Waking
  • Testosterone
  • Dehydroepiandrosterone, Saliva
  • Melatonin Evening
  • Melatonin Morning
  • Melatonin Night
  • Cortisol Morning
  • Estradiol, Saliva
  • Progesterone, Saliva

Estimated days for results: Results should arrive 21 business days after the lab receives samples.


21 business days


View here

Before You Start
  • Please read the test collection instructions carefully.
  • Your collection schedule is based on the first day of your menstrual cycle (the first day of menstrual blood flow). If you are not currently menstruating, you may begin on any day.
  • Wait to take hormone medications until after collecting the morning sample.
  • Do not discontinue any supplements or medications without consulting your healthcare provider.
  • If you have difficulty producing enough saliva: 
    • Press the tip of your tongue to the roof of your mouth and against your teeth.
    • Yawning can also help stimulate saliva production.

1 Hour Before Each Collection
  • Avoid the following activities: 
    • Eating
    • Brushing or flossing your teeth
    • Using mouthwash
    • Applying lip balm
    • Chewing gum
    • Using tobacco products
  • You may drink ONLY water during this time.

Collection Schedule
  • Day 1: The first day of your menstrual cycle. Do not collect on this day.
  • Day 2: No collection.
  • Days 3, 5, 8, 11, 12, 14, 16, 18, 20, 23, and 28: Collect your saliva sample between 7:00 AM and 9:00 AM.
  • Day 29:
    • Sample 1: Immediately upon waking
    • Sample 2: 30 minutes after waking
    • Sample 3: Between 7:00 AM and 9:00 AM
    • Sample 4: Between 11:00 AM and 1:00 PM
    • Sample 5: Between 3:00 PM and 5:00 PM
    • Sample 6: Between 10:00 PM and 12:00 AM
    • Sample 7: Between 2:30 AM and 3:30 AM

Day 29 Night
  • Before your 2:30 AM–3:30 AM collection, place your labeled collection tube at your bedside along with: 
    • A glass of water
    • A low-level light source
  • DO NOT turn on a bright light during collection, as it can suppress melatonin levels.

State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

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