
Hormones Comprehensive Profile
Mosaic Diagnostics
Sample type: Saliva
Requires fasting: No
At home test
Details
The Hormones Comprehensive Profile provides a quick assessment of sex and adrenal hormones. It is designed for men and women of any age who display symptoms of hormone imbalance.
- Cortisol Evening
- Cortisol Night
- Cortisol Noon
- Cortisol Morning - AM30
- Testosterone
- Dehydroepiandrosterone, Saliva
- Pg/E2 Ratio
- Estradiol, Saliva
- Progesterone, Saliva
Estimated days for results: Results should arrive 10 business days after the lab receives samples.
Why Test Hormones?
Each person’s hormone levels are unique, like fingerprints, and require personalized treatment. Testing major sex hormones like estradiol, estrone, estriol, progesterone, and testosterone along with adrenal hormones like DHEA and cortisol, can provide valuable information about deficiencies, excesses, and daily patterns. A personalized approach to hormone replacement therapy is much more effective than a “one-size-fits-all” approach.
Why Test Using Saliva?
Most hormones in the blood are bound to carrier proteins and not bioavailable to target tissues. Saliva measures unbound bioavailable hormones, for this reason saliva testing is thought to better relate to specific symptoms of excess or deficiency. Salivary testing provides a good option for baseline assessment of hormones and to monitor hormone replacement therapies.
10 business days
Before You Start
- Follow the test collection instructions here.
- Ship your sample Monday - Thursday only.
- If you are a menstruating woman, collect one day during days 19-23 of your menstrual cycle (assuming a 28-day cycle). Day 1 of your cycle is the first day of your period.
- If you are a man or a non-menstruating woman, collect on any day.
Hormone Use Instructions
- DO NOT discontinue any prescription medications without first consulting your healthcare provider.
- Topical hormones:
- Your last dose before sample collection should be 12-24 hours before collecting your first sample.
- DO NOT use on the day of saliva collection.
- Sublingual hormones or troches:
- Your last dose before sample collection should be 24-36 hours before collecting your first sample.
- Drink 2 full glasses of water (about 16 oz) after taking your last dose to clean the tissues.
- DO NOT take on the day of saliva collection.
- Hormone injections, subcutaneous pellets, or transdermal patches:
- Collect your samples at the halfway point between doses.
- Oral hormones (pills):
- Use as prescribed on the day of collection.
Cortisol or Cortisol-Containing Products
- If you are taking a cortisol supplement, glucocorticoid, or cortisol-containing medication, consult with your healthcare provider before collecting your samples.
- It is recommended to stop using these products 5 days before sample collection.
Day of Collection
- Avoid supplements and non-essential medications. DO NOT discontinue any prescription medications without first consulting your healthcare provider.
- Avoid caffeine-containing foods and beverages.
- Avoid anti-aging creams.
- Collect your first sample 30 minutes after waking.
- Avoid the following for 1 hour before collecting each sample:
- Eating
- Drinking
- Avoid the following for 30 minutes before collecting each sample:
- Brushing your teeth
- Flossing your teeth
- Having dental work done
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island




