Adiponectin
Quest Diagnostics
Sample type: Serum
Requires fasting: Yes
Phlebotomy required
Details
Adiponectin - Adipocytes (fat cells) express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these proteins in response to changes in energy balance. Adiponectin is a protein whose secretion from adipocytes is enhanced by insulin stimulation.
- Adiponectin, Blood
Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected
Details
Adiponectin - Adipocytes (fat cells) express a variety of proteins that function in the homeostatic control of glucose and lipid metabolism. Insulin regulates the translocation and secretion of many of these proteins in response to changes in energy balance. Adiponectin is a protein whose secretion from adipocytes is enhanced by insulin stimulation.
It has been suggested that the development of non-insulin dependent (Type II) diabetes may involve dysregulation of adiponectin secretion. In support of the link between obesity and Type II diabetes, it has been shown that decreased expression of adiponectin correlates with insulin resistance, and that adiponectin appears to be a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
Individuals with low adiponectin levels have a 3X greater risk of developing metabolic syndrome [1]. Men with two or more risk factors for metabolic syndrome and high adiponectin levels are half as likely to develop metabolic syndrome as men with low adiponectin levels [2]. Individuals with low levels of adiponectin are up to 9X as likely to develop type 2 diabetes [3]. Individuals with low adiponectin levels have a 2X increase in the prevalence of CAD [4]. Adiponectin levels in the blood can be increased by thiazolidinediones, such as pioglitazone [5].
It has been suggested that the development of non-insulin dependent (Type II) diabetes may involve dysregulation of adiponectin secretion. In support of the link between obesity and Type II diabetes, it has been shown that decreased expression of adiponectin correlates with insulin resistance, and that adiponectin appears to be a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
Individuals with low adiponectin levels have a 3X greater risk of developing metabolic syndrome [1]. Men with two or more risk factors for metabolic syndrome and high adiponectin levels are half as likely to develop metabolic syndrome as men with low adiponectin levels [2]. Individuals with low levels of adiponectin are up to 9X as likely to develop type 2 diabetes [3]. Individuals with low adiponectin levels have a 2X increase in the prevalence of CAD [4]. Adiponectin levels in the blood can be increased by thiazolidinediones, such as pioglitazone [5].
References:
1. Chen SJ et al. PLoS ONE. 2012; 7: e45693.
2. Kotooka N et al. Int J Cardiol. 2012 Nov 26. pii: S0167-5273(12)01441-6. doi:10.1016/j.ijcard.2012.10.066. [Epub ahead of print].
3. Daimon M et al. Diabetes Care. 2003; 26: 2015-2020.
4. Kumada M et al. Arterioscler Thromb Vasc Biol. 2003; 23: 35-39.
5. McCoy RG et al. Mayo Clin Proc. 2012; 87: 561-570.
1. Chen SJ et al. PLoS ONE. 2012; 7: e45693.
2. Kotooka N et al. Int J Cardiol. 2012 Nov 26. pii: S0167-5273(12)01441-6. doi:10.1016/j.ijcard.2012.10.066. [Epub ahead of print].
3. Daimon M et al. Diabetes Care. 2003; 26: 2015-2020.
4. Kumada M et al. Arterioscler Thromb Vasc Biol. 2003; 23: 35-39.
5. McCoy RG et al. Mayo Clin Proc. 2012; 87: 561-570.
What type of sample is required for this test?
1 mL serum
Test Resources
For more information, please consult your healthcare provider.
4–6 business days
Male
BMI <25 kg/m² 2.3–15.2 µg/mL
BMI 25–30 kg/m² 2.1–16.7 µg/mL
BMI >30 kg/m² 2.2–12.9 µg/mL
Female
BMI <25 kg/m² 2.9–30.4 µg/mL
BMI 25–30 kg/m² 2.5–26.8 µg/mL
BMI >30 kg/m² 3.9–21.8 µg/mL
BMI <25 kg/m² 2.3–15.2 µg/mL
BMI 25–30 kg/m² 2.1–16.7 µg/mL
BMI >30 kg/m² 2.2–12.9 µg/mL
Female
BMI <25 kg/m² 2.9–30.4 µg/mL
BMI 25–30 kg/m² 2.5–26.8 µg/mL
BMI >30 kg/m² 3.9–21.8 µg/mL
Overnight fasting is required.
- Fasting before a blood draw means you don't eat or drink anything except water.
- Your doctor should provide any special instructions related to fasting for your test. Always follow your doctor's instructions.
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
Specimen
- Preferred Specimen(s): 1 mL serum
- Alternative: NA
- Minimum Volume: 0.5 mL
- Collection Instructions: NA
Storage and shipping instructions
- Transport Container: Transport tube
- Transport Temperature: Refrigerated (Cold Packs)
- Specimen Stability:
- Room temperature: 4 days
- Refrigerated: 14 days
- Frozen: 28 days
- Reject Criteria: NA
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
