Apolipoprotein Evaluation
Quest Diagnostics
Sample type: Serum
Requires fasting: No
Phlebotomy required
Details
Apolipoprotein Evaluation - Apolipoprotein A1 is the primary protein associated with HDL cholesterol. Like HDL cholesterol, increased concentrations are associated with reduced risk of cardiovascular disease. Apolipoprotein B-100 is the primary protein associated with LDL cholesterol and other lipid particles. Like LDL cholesterol, increased concentrations are associated with increased risk of cardiovascular disease. The ratio of these two apolipoproteins correlates with risk of cardiovascular disease.
- Apolipoprotein B
- Apolipoprotein A-1, Blood
- Apolipoprotein B/Apolipoprotein A-1
Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected
4–6 business days
Male ≥115 mg/dL
Female ≥125 mg/dL
Risk Category Male Female
Optimal ≥115 mg/dL ≥125 mg/dL
High <115 mg/dL <125 mg/dL
Cardiovascular event risk category cut points (optimal, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188–205.
Apolipoprotein B:
Apolipoprotein B <90 mg/dL
Risk Category
Optimal <90 mg/dL
Moderate 90-129 mg/dL
High ≥130 mg/dL
A desirable treatment target may be <80 mg/dL or lower depending on the risk category of the patient, including patients on lipid-lowering therapies, patients with ASCVD, diabetes with >1 risk factor, Stage 3 or greater CKD with albuminuria, or heterozygous familial hypercholesterolemia. ApoB relative risk category cut points are based on AACE/ACE and ACC/AHA recommendations (Grundy SM, et al. 2019. doi:10.1016/j.jacc.2018.11.002; Handelsman Y, et al. 2020. doi:10.4158/CS-2020-0490).
Apolipoprotein B/A1 Ratio:
Male <0.77
Female <0.63
Risk Category Male Female
Optimal <0.77 <0.63
Moderate 0.77–0.95 0.63–0.78
High >0.95 >0.78
Cardiovascular event risk category cut points (optimal, moderate, high) are based on the AMORIS study, Walldius G et al. J Intern Med. 2004;255:188–205.
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 1 mL serum
- Alternative: NA
- Minimum Volume: 0.5 mL
- Collection Instructions: NA
- Transport Container: Transport tube
- Transport Temperature: Room Temperature
- Specimen Stability:
- Room temperature: 7 days
- Refrigerated: 7 days
- Frozen: 30 days
- Reject Criteria:
- Grossly lipemic
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
