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Quest Diagnostics

DNA (ds) Antibody

Quest Diagnostics

Sample type: Serum

Requires fasting: No

Phlebotomy required


Details

DNA (ds) Antibody - This test measures the presence of anti-double-stranded DNA (ds-DNA) antibodies in the blood. Positive dsDNA Antibody is detected in patients with active systemic lupus erythematosus (SLE) and approximately 20% of patients with Mixed Connective Tissue Disease and can help in diagnosing the autoimmune conditions and detect disease flares.


  • DNA (ds) Antibody

Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected

DNA (ds) Antibody
This test measures the presence of anti-double-stranded DNA (ds-DNA) antibodies in the blood. Positive dsDNA Antibody is detected in patients with active systemic lupus erythematosus (SLE) and approximately 20% of patients with Mixed Connective Tissue Disease and can help in diagnosing the autoimmune conditions and detect disease flares.

What patients is this test right for?
This test is particularly relevant for individuals showing symptoms suggestive of autoimmune disorders like SLE or other autoimmune disorders, to confirm diagnosis, assess disease activity, and guide treatment decisions. Symptoms may include:
  • Skin rashes, especially with sun exposure
  • A characteristic butterfly-shaped rash across the cheeks and nose
  • Joint pain and swelling
  • Fatigue
  • Fever
  • Hair loss
  • Kidney problems
  • Neurological symptoms

What type of sample is required for this test?
1 mL serum.

Test Resources
For more information, please consult your healthcare provider.


2–5 business days


≤4 IU/mL   Negative
5-9 IU/mL     Indeterminate
≥10 IU/mL  Positive


  • Autoimmune

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

  • Location: Visit a nearby Quest Diagnostics Patient Service Center.
  • Cost: $10 sample collection fee (paid during lab order checkout).
  • Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
  • Collection Instructions:
    • Bring a valid ID.
    • Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
  • Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
  • More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

  • Location: Sample collection at your home or office.
  • Cost: $85 sample collection fee (paid during lab order checkout).
  • Availability: Available in most locations enter your ZIP code during checkout to confirm.
  • Scheduling: Schedule your appointment here through your Fullscript account.
  • Collection Instructions:
    • Have your digital or printed requisition form and valid ID ready.
    • Your phlebotomist will contact you by phone to coordinate arrival.
  • More Info: Getlabs blood draw guide

 Specimen
  • Preferred Specimen(s): 1 mL serum 
  • Alternative: NA 
  • Minimum Volume: 0.5 mL 
  • Collection Instructions: NA 
 Storage and shipping instructions
  • Transport Container: Transport tube 
  • Transport Temperature: Room Temperature 
  • Specimen Stability
    • Room temperature: 4 days 
    • Refrigerated: 7 days 
    • Frozen: 30 days 
  • Reject Criteria
    • Gross hemolysis • Grossly lipemic • Grossly icteric 

State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

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