Factor II Activity, Clotting
Quest Diagnostics
Sample type: Plasma
Requires fasting: No
Phlebotomy required
Details
Factor II Activity, Clotting - The Factor II Activity clotting assay provides a quantitative level of Factor II (also known as Prothrombin) activity. Factor II/Prothrombin is essential for normal hemostasis and deficiencies are associated with increased bleeding risk. As a vitamin K- dependent clotting factor, decreased levels are observed with vitamin K antagonists (eg. warfarin therapy) and vitamin K deficiency. Deficiencies may also occur with hepatic dysfunction or as a result of inhibitor development. Antibodies to prothrombin can occur in patients with anti- phospholipid antibodies and can cause significant clinical bleeding; however, because these antibodies bind to a nonactive portion of the molecule, increased clearance occurs, so that a deficiency rather than an inhibitor is detected. Congenital Factor II deficiency is extremely rare.
- Coag Factor II Activity
Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected
Anticoagulant interference: if not clinically contraindicated, avoid warfarin therapy for approximately 2 weeks before testing. Direct Xa or thrombin inhibitor therapy may cause falsely low levels (avoid for approximately 2-3 days before testing if not clinically contraindicated.
2–5 business days
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 1 mL frozen platelet-poor plasma collected in 3.2% sodium citrate (light blue-top) tube
- Alternative: NA
- Minimum Volume: 0.5 mL
- Collection Instructions: NA
- Transport Container: ACD (yellow-top) tube; Transport tube
- Transport Temperature: Frozen
- Specimen Stability:
- Frozen: 28 days
- Reject Criteria:
- Hemolysis • Received thawed
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
