Factor V Activity, Clotting

Quest Diagnostics

Sample type: Plasma

Requires fasting: No

Phlebotomy required

Details

Factor V Activity, Clotting - This test measures coagulation factor V activity and may be used to help determine the cause of a prolonged prothrombin time (PT) or activated partial thromboplastin time (aPTT).

Biomarker summary

Coag Factor V Activity

Additional details

Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected

Details

Coagulation factor V plays an essential role in hemostasis by promoting thrombin generation at the activated platelet surface. Deficiency of factor V leads to a rare bleeding disorder and can be congenital or acquired. Congenital factor V deficiency, also known as parahemophilia or Owren's disease, has an incidence of 1 per one million [1] and is caused by pathogenic variants of the F5 gene, which encodes factor V. Acquired factor V deficiency can be caused by liver disease, consumptive coagulopathies, disseminated intravascular coagulation, or inhibitors (autoantibodies or alloantibodies) that interfere with factor V activity. Inhibitors to factor V may be induced by chemical agents, drugs, or surgical procedures using bovine thrombin [1].

Factor activity assays, including factor V activity assay, are usually indicated in patients with bleeding symptoms and prolonged PT and aPTT [1].

The results of this test should be interpreted in the context of pertinent clinical and family history and physical examination findings.

Reference
1. Tabibian S, et al. Semin Thromb Hemost. 2019;45(5):523-543.

What type of sample is required for this test?

1 mL frozen platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube

Test Resources

For more information, please consult your healthcare provider.

Average sample processing time

2–5 business days

Reference range

65-150 % normal

Health categories

Hematology

Patient instructions

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

Location: Visit a nearby Quest Diagnostics Patient Service Center.
Cost: $10 sample collection fee (paid during lab order checkout).
Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
Collection Instructions:

Bring a valid ID.
Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.

Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

Location: Sample collection at your home or office.
Cost: $85 sample collection fee (paid during lab order checkout).
Availability: Available in most locations – enter your ZIP code during checkout to confirm.
Scheduling: Schedule your appointment here through your Fullscript account.
Collection Instructions:

Have your digital or printed requisition form and valid ID ready.
Your phlebotomist will contact you by phone to coordinate arrival.

More Info: Getlabs blood draw guide

In-office phlebotomy instructions

Specimen

Preferred Specimen(s): 1 mL frozen platelet-poor plasma collected in a 3.2% sodium citrate (light blue-top) tube
Alternative: NA
Minimum Volume: 0.5 mL
Collection Instructions: NA

Storage and shipping instructions