Hepatitis Panel, Acute with Reflex to Confirmation
Quest Diagnostics
Sample type: Serum
Requires fasting: No
Phlebotomy required
Details
Hepatitis Panel, Acute with Reflex to Confirmation - This panel may be helpful in the diagnosis of acute or recent infection with hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the 3 most common pathogens of viral hepatitis in the United States.
Reflex testing uses predefined clinical logic to automatically order one or more follow-up tests based on the initial test results. Reflex tests are performed automatically without the intervention of the ordering practitioner. They are conducted using the same sample your Patient already provided. If reflex tests are required, there will be additional charges.
Initial test
- Hepatitis A IgM
- Hepatitis B Core Antibody IgM
- Hepatitis C Virus Ab
- Hepatitis B Surface Antigen
Possible reflex biomarkers
- Hepatitis B Surface Antigen, Serum/Plasma, Neutralization Test [Presence]
- Hepatitis C Viral RNA, Quantitative, Real-Time PCR (Units/volume)
- Hepatitis C Viral RNA, Quantitative, Real-Time PCR (Log units/volume)
Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected
Hepatitis Panel, Acute with Reflex to Confirmation - This panel may be helpful in the diagnosis of acute or recent infection with hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the 3 most common pathogens of viral hepatitis in the United States [1].
Acute symptoms and signs are similar among HAV, HBV, and HCV infection and may include fever, fatigue, loss of appetite, nausea, abdominal discomfort, dark urine, pale stools, and jaundice [1-4]. This panel may help establish diagnosis of these 3 viral hepatitis infections in symptomatic patients.
This panel includes 4 tests with reflexes: HAV IgM antibody, hepatitis B surface antigen (HBsAg) with reflex to confirmation, hepatitis B core IgM antibody (HBcAb IgM), and HCV antibody with reflex to HCV RNA quantitative real-time PCR. The section below outlines the roles of the analytes assessed with this panel.
- HAV IgM: Presence indicates current or recent infection or recent vaccination. A negative result indicates absence of acute infection [2].
- HBsAg with reflex confirmation: Presence indicates that a person has a current HBV infection and is infectious [3].
- HBcAb IgM: Presence indicates HBV infection within the preceding 4 to 6 months (ie, acute/recent infection) [3].
- HCV antibody with reflex to HCV RNA: Presence (with detectable HCV RNA) indicates current infection. A positive result with a "not detected" HCV RNA reflex result may indicate a resolved infection or a biological false-positive antibody screening test [4].
The results of the test in the panel should be interpreted in the context of pertinent clinical history and physical examination findings.
References- Viral Hepatitis Surveillance - United States, 2019. Centers for Disease Control and Prevention. Accessed January 16, 2021. https://www.cdc.gov/hepatitis/statistics/2019surveillance/pdfs/2019HepSurveillanceRpt.pdf
- Nelson NP, et al. MMWR Recomm Rep. 2020;69(5):1-38.
- Roush SW, et al. Chapter 22: laboratory support for surveillance of vaccine-preventable diseases. In: Roush SW, et al, eds. Manual for the Surveillance of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention. Reviewed June 3, 2021. Accessed January 16, 2022. https://www.cdc.gov/vaccines/pubs/surv-manual/chpt22-lab-support.html
- Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 2013;62(18):362-365.
2–5 business days
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 5 mL serum
- Alternative: NA
- Minimum Volume: 2.5 mL
- Collection Instructions: NA
- Transport Container: Transport tube
- Transport Temperature: Room Temperature
- Specimen Stability:
- Room temperature: 72 hours
- Refrigerated: 14 days
- Frozen: 21 days
- Reject Criteria:
- Gross hemolysis • Grossly lipemic
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
