Hepatitis Panel, General
Quest Diagnostics
Sample type: Serum
Requires fasting: No
Phlebotomy required
Details
Hepatitis Panel, General - This panel provides information on infection and the immune response to hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the 3 most common causes of viral hepatitis in the United States. In patients with unexplained elevated liver enzyme levels, this panel may be helpful in evaluating etiology for these viral hepatitides.
Reflex testing uses predefined clinical logic to automatically order one or more follow-up tests based on the initial test results. Reflex tests are performed automatically without the intervention of the ordering practitioner. They are conducted using the same sample your Patient already provided. If reflex tests are required, there will be additional charges.
Initial test
- Hepatitis A Antibody, Total
- Hepatitis B Core Antibody, Total
- Hepatitis B Surface Antibody, Qualitative
- Hepatitis C Virus Ab
- Hepatitis B Surface Antigen
Possible reflex biomarkers
- Hepatitis B Surface Antigen, Serum/Plasma, Neutralization Test [Presence]
- Hepatitis C Viral RNA, Quantitative, Real-Time PCR (Units/volume)
- Hepatitis C Viral RNA, Quantitative, Real-Time PCR (Log units/volume)
Estimated days for results: Results should be available within 2 - 5 business days after samples are received at the lab.
Details
Hepatitis Panel, General - This panel provides information on infection and the immune response to hepatitis A virus (HAV), hepatitis B virus (HBV), and hepatitis C virus (HCV), the 3 most common causes of viral hepatitis in the United States. In patients with unexplained elevated liver enzyme levels, this panel may be helpful in evaluating etiology for these viral hepatitides [1-4].
This panel includes 5 tests with reflexes: total HAV antibody, qualitative hepatitis B surface antibody (HBsAb), hepatitis B surface antigen (HBsAg) with reflex confirmation, total hepatitis B core antibody (HBcAb), and HCV antibody with reflex to HCV RNA quantitative real-time PCR.
The section below outlines the roles of the analytes assessed with this panel.
- Total HAV antibody: Presence of total HAV antibody is consistent with (1) immunity due to prior infection or vaccination; or (2) current HAV infection or recent HAV vaccination [2].
- Qualitative HBsAb: Presence indicates resolution of HBV infection or prior vaccination. To determine immune status due to past HBV infection or vaccination (ie, HBsAb titer ≥10 mIU/mL), a quantitative HBsAb test must be ordered [3].
- HBsAg with reflex confirmation: Presence indicates that a person has a current HBV infection and is infectious [3].
- Total HBcAb: Presence indicates past or current HBV infection [3].
- HCV antibody with reflex to HCV RNA: Presence (with detectable HCV RNA) indicates current infection. A positive result with a "not detected" HCV RNA reflex result may indicate a resolved infection or a biological false-positive antibody screening test [4].
The results of the test in the panel should be interpreted in the context of pertinent clinical history and physical examination findings.
- Viral Hepatitis Surveillance - United States, 2019. Centers for Disease Control and Prevention. Accessed January 16, 2022. https://www.cdc.gov/hepatitis/statistics/2019surveillance/pdfs/2019HepSurveillanceRpt.pdf
- Nelson NP, et al. MMWR Recomm Rep. 2020;69(5):1-38.
3. Roush SW, et al. Chapter 22: laboratory support for surveillance of vaccine-preventable diseases. In: Roush SW, et al, eds. Manual for the Surveillance of Vaccine-Preventable Diseases. Centers for Disease Control and Prevention. Reviewed June 3, 2021. Accessed January 16, 2022. https://www.cdc.gov/vaccines/pubs/surv-manual/chpt22-lab-support.html
4. Centers for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep. 2013;62(18):362-365.
2–5 business days
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 6 mL serum
- Alternative: NA
- Minimum Volume: 3 mL
- Collection Instructions: NA
- Transport Container: Serum separator tube (SST)
- Transport Temperature: Room Temperature
- Specimen Stability:
- Room temperature: 72 hours
- Refrigerated: 14 days
- Frozen: 30 days
- Reject Criteria:
- Gross hemolysis • Grossly lipemic
State restrictions:
Patient can't order this test if they are located in Puerto Rico, Rhode Island, New Jersey, New York, or Hawaii
