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Quest Diagnostics

Lipoprotein Fractionation Ultracentrifugation

Quest Diagnostics

Sample type: Serum

Requires fasting: No

Phlebotomy required

Details

Lipoprotein Fractionation Ultracentrifugation - This panel measures serum concentrations of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol and provides a calculated concentration of very low-density lipoprotein (VLDL) cholesterol. Comprehensive lipid assessment aids in evaluating cardiovascular disease (CVD) risk and the likelihood of an ischemic event. It is also useful for the prevention and management of atherosclerotic disease and diagnosis of metabolic syndrome.

  • Triglycerides
  • Total Cholesterol
  • HDL Cholesterol
  • LDL Cholesterol
  • VLDL, Calculated

Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected

Details
Lipoprotein Fractionation Ultracentrifugation - This panel measures serum concentrations of total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol and provides a calculated concentration of very low-density lipoprotein (VLDL) cholesterol. Comprehensive lipid assessment aids in evaluating cardiovascular disease (CVD) risk and the likelihood of an ischemic event. It is also useful for the prevention and management of atherosclerotic disease and diagnosis of metabolic syndrome [1].

CVD is the leading cause of death in the United States. Individuals with high LDL cholesterol and triglyceride levels are at elevated risk for developing CVD and having an ischemic event [2,3]. The American Heart Association recommends that Americans aged 20 and above have their lipid levels tested every 4 to 6 years. Children should have their cholesterol tested for the first time between ages 9 and 11 and again between ages 17 and 21. Testing should start earlier if there is a family history of high cholesterol [4].

Treatment with N-acetyl cysteine for acetaminophen overdose may generate a falsely low result for cholesterol [5]. Venipuncture immediately after or during administration of the painkiller metamizole (dipyrone) may also lead to falsely low results for cholesterol [6].

Note: Any or all individual tests from a panel can be ordered separately.

The results of this test should be interpreted in the context of pertinent clinical and family history as well as physical examination findings.

References
1. Stone NJ, et al. Circulation. 2014;129(25 Suppl 2):S1-S45.
2. CDC. Heart disease facts. Accessed January 3, 2022. https://www.cdc.gov/heartdisease/facts.htm
3. Arbel Y, et al. Card Diabetol. 2016;15:11.
4. Grundy SM, et al. Circulation. 2019;139(25):e1082-e1143.
5. Beckman Coulter AU analyzers. Instructions for use. Beckman Coulter Inc; 2015. Accessed January 19, 2023. https://www.beckmancoulter.com/wsrportal/techdocs?docname=/cis/BAOSR6X16/%25%25/EN_CHOL%20OSR%20General%20Chemistry.pdf6. Gascon N, et al. Clin Chem. 1993;39(6):1033-1036.

What type of sample is required for this test?
4 mL serum

Test Resources
For more information, please consult your healthcare provider.

2–5 business days

  • Cardiovascular
If a cholesterol measurement is to be performed along with triglycerides, but not part of a lipid panel, then you should be fasting 9-12 hours prior to collection. If the cholesterol is ordered as part of a lipid panel, then a fasting sample is not required.

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

  • Location: Visit a nearby Quest Diagnostics Patient Service Center.
  • Cost: $10 sample collection fee (paid during lab order checkout).
  • Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
  • Collection Instructions:
    • Bring a valid ID.
    • Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
  • Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
  • More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

  • Location: Sample collection at your home or office.
  • Cost: $85 sample collection fee (paid during lab order checkout).
  • Availability: Available in most locations – enter your ZIP code during checkout to confirm.
  • Scheduling: Schedule your appointment here through your Fullscript account.
  • Collection Instructions:
    • Have your digital or printed requisition form and valid ID ready.
    • Your phlebotomist will contact you by phone to coordinate arrival.
  • More Info: Getlabs blood draw guide
 Specimen
  • Preferred Specimen(s): 4 mL serum 
  • Alternative: NA 
  • Minimum Volume: 2 mL 
  • Collection Instructions: NA 
 Storage and shipping instructions
  • Transport Container: Transport tube 
  • Transport Temperature: Refrigerated (Cold Packs) 
  • Specimen Stability: 
    • Room temperature: 24 hours 
    • Refrigerated: 7 days 
    • Frozen: -20° C: 14 days, -70° C: 1 year 
  • Reject Criteria: 
    • Received room temperature 
State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

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