PrEP HIV-1/2 Antigen/Antibodies, 4th Generation, Reflex to Differentiation
Quest Diagnostics
Sample type: Serum
Requires fasting: No
Phlebotomy required
Details
PrEP HIV-1/2 Antigen/Antibodies, 4th Generation, Reflex to Differentiation - This profile is for clinician determination of HIV status for PrEP provision for patients without recent or ongoing antiretroviral prophylaxis use who are considering initiating PrEP. If the patient has not taken oral PrEP within the last 3 months or has not received cabotegravir in the past 12 months, then current guidelines recommend screening with an HIV Antibody/Antigen test with reflex to confirmation. If an HIV exposure-prone event and signs and symptoms of acute HIV are reported within the prior 4 weeks and the antibody confirmation is negative or indeterminate, additional testing with an HIV-1 RNA assay on a new specimen is recommended to determine PrEP eligibility.
Reflex testing uses predefined clinical logic to automatically order one or more follow-up tests based on the initial test results. Reflex tests are performed automatically without the intervention of the ordering practitioner. They are conducted using the same sample your Patient already provided. If reflex tests are required, there will be additional charges.
Initial test
- HIV 1+2 Ab+HIV1 p24 Ag
Possible reflex biomarkers
- HIV-1 Ab
- HIV-2 Ab
Estimated days for results: Results should be available within 2 - 5 business days after samples are received at the lab.
PrEP HIV-1/2 Antigen/Antibodies, 4th Generation, Reflex to Differentiation - This profile is for clinician determination of HIV status for PrEP provision for patients without recent or ongoing antiretroviral prophylaxis use who are considering initiating PrEP. If the patient has not taken oral PrEP within the last 3 months or has not received cabotegravir in the past 12 months, then current guidelines recommend screening with an HIV Antibody/Antigen test with reflex to confirmation. If an HIV exposure-prone event and signs and symptoms of acute HIV are reported within the prior 4 weeks and the antibody confirmation is negative or indeterminate, additional testing with an HIV-1 RNA assay on a new specimen is recommended to determine PrEP eligibility.
Please refer to the U.S. Public Health Service "Preexposure Prophylaxis for the Prevention of HIV Infection in the United States - 2021 Update Clinical Practice Guideline" for additional information.
2–5 business days
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 2 mL serum
- Alternative: NA
- Minimum Volume: 1 mL
- Collection Instructions: NA
- Transport Container: Serum separator tube (SST)
- Transport Temperature: Room Temperature
- Specimen Stability:
- Room temperature: 72 hours
- Refrigerated: 5 days
- Frozen: 30 days
- Reject Criteria:
- Gross hemolysis • Frozen specimens submitted in original collection container
State restrictions:
Patient can't order this test if they are located in Puerto Rico, Hawaii, Rhode Island, New Jersey, or New York
