Protein S Activity, Antigen, Total and Free
Quest Diagnostics
Sample type: Plasma
Requires fasting: No
Phlebotomy required
Details
Protein S Activity, Antigen, Total and Free - Protein S deficiency may either be hereditary or acquired and is associated with an increased risk for venous thromboembolic disease. Congenital Protein S (PS) deficiency may be classified based on the PS Antigen (Free and Total) and activity results. Type I deficiency is characterized by a decrease in antigen and activity levels whereas a Type II deficiency will have normal antigen levels but reduced activity. A third classification, Type III deficiency, is characterized by reduced free PS antigen and activity, but normal total PS antigen levels associated with increased C4b binding protein level.
- Protein S Antigen, Free
- Protein S Antigen, Total
- Protein S, Activity
Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected
Anticoagulant interference: Expected impact by therapeutic levels (potential interference depends upon drug concentration): Vitamin K Antagonists (eg. warfarin): decrease; Heparin (UFH or LMWH): no effect to falsely increased activity levels at higher levels; Dabigatran or Argatroban (Thrombin Inhibitors): may falsely increase activity; Rivaroxaban, Apixaban, Edoxaban (Factor Xa Inhibitors): may falsely increase activity.
2–5 business days
Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:
Quest Diagnostics Patient Service Centers (PSC)
- Location: Visit a nearby Quest Diagnostics Patient Service Center.
- Cost: $10 sample collection fee (paid during lab order checkout).
- Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
- Collection Instructions:
- Bring a valid ID.
- Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
- Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
- More Info: Quest Diagnostics blood draw guide
Getlabs Mobile Phlebotomy
- Location: Sample collection at your home or office.
- Cost: $85 sample collection fee (paid during lab order checkout).
- Availability: Available in most locations – enter your ZIP code during checkout to confirm.
- Scheduling: Schedule your appointment here through your Fullscript account.
- Collection Instructions:
- Have your digital or printed requisition form and valid ID ready.
- Your phlebotomist will contact you by phone to coordinate arrival.
- More Info: Getlabs blood draw guide
- Preferred Specimen(s): 1 mL plasma collected in each of two 3.2 % separate sodium citrate (light blue-top) tubes
- Alternative: NA
- Minimum Volume: 0.5 mL
- Collection Instructions: NA
- Transport Container: Transport tube
- Transport Temperature: Frozen
- Specimen Stability:
- Frozen: 30 days
- Reject Criteria:
- Hemolysis
State restrictions:
Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island
