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Quest Diagnostics

Quest AD-Detect® Beta-Amyloid 42/40 Ratio, Plasma

Quest Diagnostics

Sample type: Plasma

Requires fasting: No

Phlebotomy required


Details

This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.


  • Amyloid beta 42 peptide
  • Amyloid beta 40 peptide
  • Amyloid beta 42/40 Ratio

Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected

Details
This LC-MS/MS assay measures beta-amyloid 40 (AB40) as well as AB42 in plasma, rather than AB42 alone. This permits the normalization of beta amyloid levels circulating in plasma in different patients. Using the ratio of beta-amyloid 42/beta-amyloid 40, improves sensitivity and specificity for detecting Alzheimer's disease.

Test Resources

2–5 business days


ABeta 42                        Not established         pg/mL
ABeta 40                        Not established         pg/mL
ABeta 42/40 Ratio       ≥0.170

  • Neurological

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

  • Location: Visit a nearby Quest Diagnostics Patient Service Center.
  • Cost: $10 sample collection fee (paid during lab order checkout).
  • Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
  • Collection Instructions:
    • Bring a valid ID.
    • Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
  • Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
  • More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

  • Location: Sample collection at your home or office.
  • Cost: $85 sample collection fee (paid during lab order checkout).
  • Availability: Available in most locations enter your ZIP code during checkout to confirm.
  • Scheduling: Schedule your appointment here through your Fullscript account.
  • Collection Instructions:
    • Have your digital or printed requisition form and valid ID ready.
    • Your phlebotomist will contact you by phone to coordinate arrival.
  • More Info: Getlabs blood draw guide

 Specimen
  • Preferred Specimen(s): 1.2 mL plasma collected in K2 EDTA tube 
  • Alternative: NA 
  • Minimum Volume: 0.6 mL 
  • Collection Instructions: NA 
 Storage and shipping instructions
  • Transport Container: Transport tube 
  • Transport Temperature: Frozen 
  • Specimen Stability
    • Refrigerated: 72 hours 
    • Frozen: -20° C: 32 days, -70° C: 77 days 
  • Reject Criteria: NA 

Minimum age:

18

State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

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