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Quest Diagnostics

RPR (Diagnosis) with Reflex to Titer and Treponema pallidum Antibody, IA

Quest Diagnostics

Sample type: Serum

Requires fasting: No

Phlebotomy required


Details

RPR (Diagnosis) with Reflex to Titer and Treponema pallidum Antibody, IA - This test is used to aid in the diagnosis of syphilis using the traditional algorithm. Testing can be performed for individuals suspected of syphilis based on signs and symptoms or for screening asymptomatic individuals. Screening is recommended in certain populations at increased risk for infection and pregnant women.


Reflex testing uses predefined clinical logic to automatically order one or more follow-up tests based on the initial test results. Reflex tests are performed automatically without the intervention of the ordering practitioner. They are conducted using the same sample your Patient already provided. If reflex tests are required, there will be additional charges.


Initial test
  • RPR (Reagin Ab)
Possible reflex biomarkers
  • Treponema Pallidum Ab
  • RPR Titer

Estimated days for results: Results should be available in 2 - 5 business days after the sample is collected

Details
RPR (Diagnosis) with Reflex to Titer and Treponema pallidum Antibody, IA - This test is used to aid in the diagnosis of syphilis using the traditional algorithm. The algorithm starts with RPR, a nontreponemal (lipoidal antigen) serologic test, and if reactive will reflex to titer. Reactive RPR samples will be further tested with the Treponema pallidum Antibody immunoassay, a treponemal serologic test. 

Testing can be performed for individuals suspected of syphilis based on signs and symptoms or for screening asymptomatic individuals. Screening is recommended in certain populations at increased risk for infection and pregnant women.

False positive results with nontreponemal (lipoidal antigen) test results may occur due to wide range of biological conditions (e.g., autoimmune disease, cancer, infectious diseases, old age, and pregnancy). False negatives can occur in persons with recent exposure. Persons with previously treated syphilis will remain positive using a treponemal test. Therefore, a single type of serological test is insufficient for diagnosis and positive result using a nontreponemal (lipoidal antigen) test should be confirmed by a treponemal specific assay using the traditional algorithm. 

Test Resources

3–4 business days


RPR     Non-Reactive

  • Infectious Disease

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

  • Location: Visit a nearby Quest Diagnostics Patient Service Center.
  • Cost: $10 sample collection fee (paid during lab order checkout).
  • Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
  • Collection Instructions:
    • Bring a valid ID.
    • Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
  • Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
  • More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

  • Location: Sample collection at your home or office.
  • Cost: $85 sample collection fee (paid during lab order checkout).
  • Availability: Available in most locations enter your ZIP code during checkout to confirm.
  • Scheduling: Schedule your appointment here through your Fullscript account.
  • Collection Instructions:
    • Have your digital or printed requisition form and valid ID ready.
    • Your phlebotomist will contact you by phone to coordinate arrival.
  • More Info: Getlabs blood draw guide

 Specimen
  • Preferred Specimen(s): 3 mL serum 
  • Alternative: NA 
  • Minimum Volume: 1 mL 
  • Collection Instructions: NA 
 Storage and shipping instructions
  • Transport Container: Transport tube 
  • Transport Temperature: Room Temperature 
  • Specimen Stability
    • Room temperature: 4 days 
    • Refrigerated: 7 days 
    • Frozen: 30 days 
  • Reject Criteria
    • Hemolysis • Lipemia 

State restrictions:

Patient can't order this test if they are located in Hawaii, Puerto Rico, New Jersey, New York, or Rhode Island

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