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Quest Diagnostics

Very Long Chain Fatty Acids

Quest Diagnostics

Sample type: Serum

Requires fasting: Yes

Phlebotomy required


Details

Very Long Chain Fatty Acids - This panel measures specific fatty acid levels and ratios in the blood to help diagnose peroxisomal disorders such as X-linked adrenoleukodystrophy (X-ALD), X-linked adrenomyeloneuropathy (X-AMN), and Zellweger spectrum disorders.


  • Docosanoic Acid, C22:0
  • Hexacosanoic, C26:0
  • Phytanic Acid
  • Pristanic Acid
  • Tetracosanoic, C24:0
  • Very Long Chain Fatty Acids C24:0/C22:0
  • Very Long Chain Fatty Acids C26:0/C22:0
  • Pristanate/Phytanate Ratio

Estimated days for results: Results should be available within 2 - 5 business days after samples are received at the lab.

Details
Very Long Chain Fatty Acids - Peroxisomes play a vital role in several metabolic pathways, including the synthesis of plasmalogens and bile acids. They are also involved in the catabolism of Very Long Chain Fatty Acids (VLCFAs), phytanic acid, and pristanic acid. Defects in these pathways usually result in the accumulation in tissues and body fluids of one or more metabolites derived from the blocked metabolic steps. Specific accumulations are used for the differential biochemical diagnosis of numerous peroxisomal disorders. These disorders include:
  • Zellweger spectrum disorders of peroxisomal biogenesis
  • X-linked adrenoleukodystrophy (X-ALD) and its adult form X-linked adrenomyeloneuropathy (X-AMN)
  • Refsum disease (Phytanoyl-CoA hydroxylase Deficiency)
  • 2-methylacyl-CoA racemase deficiency

2–5 business days


  • Cardiovascular

Overnight fasting is required.
  • Fasting before a blood draw means you don't eat or drink anything except water.
  • Your doctor should provide any special instructions related to fasting for your test. Always follow your doctor's instructions.
  • Note that pediatric patients are not required to fast, but sample collection should occur prior to the next meal or scheduled feeding.

Do not drink alcohol for 24 hours prior to collection.

Blood Draw Options with Fullscript
Fullscript offers several convenient phlebotomy options to complete your lab testing:

Quest Diagnostics Patient Service Centers (PSC)

  • Location: Visit a nearby Quest Diagnostics Patient Service Center.
  • Cost: $10 sample collection fee (paid during lab order checkout).
  • Scheduling: Schedule your appointment here. Appointments are recommended to reduce wait times. Walk-ins are accepted, but may experience delays. Aim to arrive 10 minutes before your appointment.
  • Collection Instructions:
    • Bring a valid ID.
    • Bring your digital or printed requisition form, available in the Labs tab of your Fullscript account.
  • Check-in: Scan the QR code from your confirmation email or follow kiosk instructions.
  • More Info: Quest Diagnostics blood draw guide

Getlabs Mobile Phlebotomy

  • Location: Sample collection at your home or office.
  • Cost: $85 sample collection fee (paid during lab order checkout).
  • Availability: Available in most locations – enter your ZIP code during checkout to confirm.
  • Scheduling: Schedule your appointment here through your Fullscript account.
  • Collection Instructions:
    • Have your digital or printed requisition form and valid ID ready.
    • Your phlebotomist will contact you by phone to coordinate arrival.
  • More Info: Getlabs blood draw guide

 Specimen
  • Preferred Specimen(s): 1 mL serum collected in red-top tube (no gel) 
  • Alternative: NA 
  • Minimum Volume: 0.2 mL 
  • Collection Instructions: NA 
 Storage and shipping instructions
  • Transport Container: Transport tube 
  • Transport Temperature: Frozen 
  • Specimen Stability: 
    • Refrigerated: 7 days 
    • Frozen: 28 days 
  • Reject Criteria: 
    • Hemolysis • Lipemia • Serum separator tube (SST) • Non-fasting samples 

State restrictions:

Patient can't order this test if they are located in Puerto Rico, Hawaii, Rhode Island, New Jersey, or New York

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