Angiotensin II Receptor Blocker (ARB) Drug-Nutrient Interactions

ARBs include medications such as losartan, valsartan, irbesartan, telmisartan, candesartan, eprosartan, olmesartan, and azilsartan. Angiotensin II Receptor Blockers (ARBs) are used for managing high blood pressure and heart failure, can interact with certain nutrients and dietary supplements.

Read more in our Supplement-Sciences.com article: Beyond Low Sodium and Weight Loss: Which Supplements Can Bring Blood Pressure Down.

Here are some drug-nutrient or supplement interactions involved with ARBs:

Potassium and Potassium Supplements: ARB medications can reduce potassium clearance by the kidneys. This can cause excessive potassium to build up in the blood and can lead to irregular heartbeat when very high levels of potassium are consumed. Don’t use potassium supplements or electrolyte drinks without your physician’s approval.
- DO NOT USE POTASSIUM-BASED SALT SUBSTITUTES: Many salt substitutes are high in potassium. Since ARBs can raise potassium levels, using these substitutes might further increase the risk of high potassium blood levels. [PMID: 31498767]
Vitamin D Supplements: In some cases, vitamin D can increase the blood pressure-lowering effects of ARBs. This interaction may not be harmful but should be monitored.
St. John’s Wort: This supplement can reduce the effectiveness of many medications, potentially including ARBs, by affecting how the body breaks down the drugs.
Anti-Inflammatory Drugs (NSAIDs): NSAIDs can reduce the effectiveness of ARBs and increase the risk of kidney problems. This includes over-the-counter medications like ibuprofen and naproxen.
Alcohol: While not a nutrient or supplement, alcohol can increase the blood pressure-lowering effects of ARBs, potentially leading to hypotension (low blood pressure).
Antacids: Some antacids, especially those containing aluminum or magnesium, can affect the absorption of ARBs when taken at the same time.

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Stephanie Figon, MS, RDN, LD

Supplements@NutriScape.NET

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Dietary supplements are not designed to diagnose, treat, cure, or prevent any disease. Supplement Sciences seeks to provide comprehensive access to the most relevant supplement information along with convenient online ordering. We do not provide medical advice and cannot guarantee that every product suggested is completely without risk. Since each person is unique in their health history and medication use, it is important to discuss supplements with your personal physician. Specifically, pregnant women and individuals being treated for serious medical issues including cancer or liver or kidney problems must consult their physician about every nutritional supplement they plan to take.

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