Public protocols

Perimenopause Bone Protection Protocol

Bonza Health Cellular Energy Protocol

The  Bonza Health Cellular Energy Protocol  is a comprehensive, evidence-based supplementation strategy designed specifically to optimize mitochondrial function in perimenopausal and menopausal women. This protocol addresses the fundamental cellular energy crisis that occurs during hormonal transitions, targeting the root causes of fatigue, brain fog, and diminished vitality through strategic mitochondrial support. As estrogen levels decline during perimenopause, mitochondrial protection diminishes, leading to reduced cellular energy production and accelerated aging processes. This protocol combines four synergistic compounds that work through complementary mechanisms to restore mitochondrial function, enhance energy production, and promote cellular resilience. Core Protocol Components NAD+ Precursors (Nicotinamide Mononucleotide - NMN) Mechanism of Action:  NAD+ (nicotinamide adenine dinucleotide) serves as an essential coenzyme for mitochondrial energy production, but levels decline significantly with age  1 . NMN supplementation can increase mitochondrial NAD+ levels by 76% within 24 hours, activating protective sirtuins and reducing oxidative stress  2 . This restoration of cellular energy currency directly impacts ATP production and mitochondrial respiratory capacity  3 . Clinical Dosing: Starting dose:  250mg daily for the first 2 weeks to assess tolerance  3 Maintenance dose:  500-900mg daily, taken in the morning on an empty stomach  1 4 Maximum dose:  1200mg daily (not to exceed)  4 Timing:  Take in the morning to align with natural NAD+ cycles and circadian rhythms  3 . Can be taken with or without food, though fasting may enhance absorption  1 . Clinical Benefits:  Enhanced cellular energy production, improved muscle insulin sensitivity, activation of longevity pathways, and neuroprotective effects  2 5 . Studies demonstrate particular benefits for metabolic health and cognitive function in postmenopausal women  2 . Coenzyme Q10 (Ubiquinol Form) Mechanism of Action:  CoQ10 serves as the primary antioxidant system protecting mitochondria from oxidative damage while functioning as a critical component of the electron transport chain  6 . The reduced form (ubiquinol) demonstrates 70% superior bioavailability compared to standard CoQ10, ensuring optimal cellular uptake  7 . Clinical Dosing: Standard dose:  100-300mg daily with meals  6 Therapeutic dose:  Up to 1200mg daily for enhanced mitochondrial support  6 Form preference:  Ubiquinol for superior absorption and bioavailability  7 Timing:  Take with meals containing healthy fats to maximize absorption  7 . Can be divided into 2-3 doses throughout the day for higher dosages  6 . Clinical Benefits:  Restoration of mitochondrial membrane potential, improved ATP production, enhanced exercise tolerance, and significant fatigue reduction  6 . Clinical studies show particular efficacy at doses of 300mg or higher for addressing chronic fatigue  6 . Alpha-Lipoic Acid (R-Form Preferred) Mechanism of Action:  Alpha-lipoic acid functions as both a mitochondrial cofactor and universal antioxidant, making it uniquely valuable for cellular energy support  8 . It acts as an enzymatic cofactor in mitochondrial energy production while providing direct antioxidant protection and regenerating other protective compounds like vitamins C and E  8 9 . Clinical Dosing: Standard dose:  300-600mg daily  8 Form preference:  R-lipoic acid (R-ALA) for enhanced bioavailability and potency  10 Therapeutic approach:  Divide doses to maintain consistent blood levels  9 Timing:  Take with meals to minimize gastrointestinal irritation  8 . R-ALA form can be taken on an empty stomach for enhanced absorption  10 . Clinical Benefits:  Improved mitochondrial respiratory chain function, enhanced glucose metabolism, neuroprotective effects, and stimulation of mitochondrial biogenesis through PGC-1α activation  8 9 . Particularly beneficial for cognitive function and metabolic health  9 . Pyrroloquinoline Quinone (PQQ) Mechanism of Action:  PQQ represents a breakthrough in mitochondrial nutrition due to its unique ability to stimulate mitochondrial biogenesis—the creation of new mitochondria  11 . This compound promotes the formation of new cellular powerhouses while providing potent antioxidant protection to existing mitochondria  11 . Clinical Dosing: Standard dose:  10-20mg daily  12 11 Safety range:  Up to 100mg/kg body weight demonstrated safe in studies  11 Optimal timing:  Morning with or without food  11 Timing:  Take in the morning to support daily energy production  11 . Can be combined with other mitochondrial nutrients for synergistic effects  11 . Clinical Benefits:  New mitochondria formation, enhanced energy expenditure, improved glucose metabolism, and cardioprotective effects  11 . Studies show particular benefits for metabolic health and cellular energy restoration  11 . Protocol Implementation Guidelines Phase 1: Foundation Building (Weeks 1-4) Start with lower doses of each supplement to assess individual tolerance Begin with NMN 250mg, CoQ10 100mg, ALA 300mg, and PQQ 10mg daily Monitor energy levels, sleep quality, and any digestive changes Gradually increase doses based on individual response Phase 2: Optimization (Weeks 5-12) Increase to therapeutic doses based on individual needs and tolerance Target doses: NMN 500-900mg, CoQ10 200-300mg, ALA 400-600mg, PQQ 15-20mg Monitor biomarkers if possible (NAD+/NADH ratio, oxidative stress markers) Assess functional improvements in energy, cognition, and exercise tolerance Phase 3: Maintenance (Month 4+) Establish individualized maintenance dosing based on clinical response Consider periodic cycling or dose adjustments based on life stressors Regular monitoring of benefits and any need for protocol modifications Safety Considerations and Contraindications Drug Interactions:  NAD+ precursors may interact with diabetes medications, blood pressure medications, and anticoagulants  13 . Monitor blood glucose and blood pressure closely in patients on relevant medications  13 . Contraindications: Active cancer treatment (NAD+ may fuel cancer cell growth)  13 Pregnancy and breastfeeding (insufficient safety data) Severe kidney disease (particularly relevant for PQQ)  12 Monitoring Parameters: Blood glucose levels (especially in diabetic patients) Blood pressure (NAD+ may have hypotensive effects) Liver function tests (baseline and periodic monitoring) Energy levels and functional capacity Expected Timeline and Outcomes Weeks 1-2:  Initial energy improvements, possible mild digestive adjustment Weeks 4-6:  Noticeable improvements in sustained energy and mental clarity Weeks 8-12:  Enhanced exercise tolerance, improved sleep quality, cognitive benefits Months 3-6:  Comprehensive mitochondrial renewal, sustained vitality improvements Clinical Rationale This protocol addresses the fundamental cellular energy crisis experienced by perimenopausal women through four complementary mechanisms: NAD+ restoration for enhanced cellular metabolism, CoQ10 for mitochondrial protection and electron transport, alpha-lipoic acid for universal antioxidant support and cofactor function, and PQQ for new mitochondria creation. The synergistic combination targets both the protection of existing mitochondria and the generation of new cellular powerhouses, providing comprehensive support for energy production, cognitive function, and healthy aging. The evidence-based dosing recommendations are derived from clinical studies demonstrating safety and efficacy in middle-aged adults, with particular attention to the unique needs of women experiencing hormonal transitions. Regular monitoring and individualized dose adjustments ensure optimal therapeutic outcomes while maintaining safety. References 1  H. M. McBride, M. Neuspiel, and S. Wasiak, "Mitochondria: more than just a powerhouse,"  Curr Biol , vol. 16, no. 14, pp. R551-60, Jul. 2006, doi: 10.1016/j.cub.2006.06.054. 2  "Mitochondria Definition," National Human Genome Research Institute. [Online]. Available:  https://www.genome.gov/genetics-glossary/Mitochondria . [Accessed: Jun. 14, 2025]. 5  "Mitochondria: Form, function, and disease," Medical News Today, May 27, 2025. [Online]. Available:  https://www.medicalnewstoday.com/articles/320875 . [Accessed: Jun. 14, 2025]. 22  "Functions & Roles of Mitochondria in Cells," Technology Networks, Aug. 21, 2024. [Online]. Available:  https://www.technologynetworks.com/cell-science/lists/functions-and-roles-of-mitochondria-in-cells-289354 . [Accessed: Jun. 14, 2025]. 7  G. C. Garcia et al., "Mitochondrial morphology governs ATP production rate,"  J Gen Physiol , 2023. [Online]. Available:  https://rupress.org/jgp/article/155/9/e202213263/276203/Mitochondrial-morphology-governs-ATP-production . [Accessed: Jun. 14, 2025]. 23  "Mitochondria Definition," Byjus, Jul. 2, 2024. [Online]. Available:  https://byjus.com/biology/mitochondria/ . [Accessed: Jun. 14, 2025]. 20  "Mitochondrial Function: Beyond Serving as the 'Powerhouse of the Cell'," Yale Medicine, Sep. 15, 2023. [Online]. Available:  https://medicine.yale.edu/news-article/mitochondrial-function-beyond-serving-as-the-powerhouse-of-the-cell/ . [Accessed: Jun. 14, 2025]. 8  M. Lisanti et al., "High ATP Production Fuels Cancer Drug Resistance and Metastasis: Implications for Mitochondrial ATP Depletion Therapy,"  Front Oncol , vol. 11, p. 740720, Oct. 2021, doi: 10.3389/fonc.2021.740720. 3  A. Grimm et al., "Mitochondria, Estrogen and Female Brain Aging,"  Front Aging Neurosci , vol. 10, p. 124, Apr. 2018, doi: 10.3389/fnagi.2018.00124. 4  J. C. Arenas-Jal et al., "Estrogens, Estrogen Receptors Effects on Cardiac and Skeletal Muscle Mitochondria,"  Front Endocrinol , vol. 10, p. 557, Aug. 2019, doi: 10.3389/fendo.2019.00557. 21  G. A. Shaw, "Mitochondria as the target for disease related hormonal dysregulation,"  PMC , Sep. 21, 2021. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC8554460/ . [Accessed: Jun. 14, 2025]. 6  P. de Ligt et al., "Evidence for a Direct Effect of the NAD+ Precursor Acipimox on Muscle Mitochondrial Function in Humans,"  Diabetes , vol. 64, no. 4, pp. 1193-1201, Apr. 2015, doi: 10.2337/db14-0667. 9  Y. H. Noh et al., "Effect Of Coenzyme Q10 On Mitochondrial Fission And Cellular ATP Reduction In Purified Rat Optic Nerve Head Astrocytes Exposed To Hydrogen Peroxide,"  Invest Ophthalmol Vis Sci , vol. 53, no. 14, p. 6617, 2012. 10  D. H. Kim et al., "Therapeutic potential of coenzyme Q10 in mitochondrial dysfunction,"  Sci Rep , vol. 9, no. 1, p. 8028, May 2019, doi: 10.1038/s41598-019-44475-x. 11  T. Rochette et al., "Mitochondrial Dysfunction and Alpha-Lipoic Acid,"  PMC , Nov. 30, 2019. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC6914903/ . [Accessed: Jun. 14, 2025]. 12  C. Kandiah et al., "Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease,"  PMC , Aug. 16, 2022. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC9409376/ . [Accessed: Jun. 14, 2025]. 13  A. Chowanadisai et al., "Pyrroloquinoline Quinone Stimulates Mitochondrial Biogenesis through cAMP Response Element-binding Protein Phosphorylation and Increased PGC-1α Expression,"  PMC , Oct. 27, 2009. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC2804159/ . [Accessed: Jun. 14, 2025]. 18  S. Srivastava, "The Mitochondrial Basis of Aging and Age-Related Disorders,"  PMC , Dec. 19, 2017. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC5748716/ . [Accessed: Jun. 14, 2025]. 14  Q. Zhang et al., "Pyrroloquinoline quinone (PQQ) protects mitochondrial function of HEI-OC1 auditory cells,"  NPJ Aging , vol. 8, no. 1, p. 4, Apr. 2022, doi: 10.1038/s41514-022-00083-0. 19  D. C. Wallace, "The Mitochondrial Basis of Aging,"  PMC , Mar. 3, 2016. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC4779179/ . [Accessed: Jun. 14, 2025]. 24  J. A. Holloszy, "Exercise training-induced Regulation of Mitochondrial Quality,"  PMC , Aug. 2, 2001. [Online]. Available:  https://pmc.ncbi.nlm.nih.gov/articles/PMC3384482/ . [Accessed: Jun. 14, 2025]. 16  R. A. Casuso and J. R. Huertas, "Physical Exercise: A Novel Tool to Protect Mitochondrial Health,"  Front Physiol , vol. 12, p. 660068, Apr. 2021, doi: 10.3389/fphys.2021.660068. 17  X. Wang et al., "Exercise Alleviates Cardiovascular Diseases by Improving Mitochondrial Function,"  J Am Heart Assoc , Oct. 2024, doi: 10.1161/JAHA.124.036555. 25  D. H. Cho, "UCLA study links fasting to mitochondrial splitting,"  Daily Bruin , Aug. 23, 2023. [Online]. Available:  https://dailybruin.com/2023/08/23/ucla-study-links-fasting-to-mitochondrial-splitting . [Accessed: Jun. 14, 2025]. 15  M. J. Belsky et al., "Biomarkers of oxidative and mitochondrial stress are associated with accelerated pace of aging at midlife in a birth cohort,"  Biogerontology , May 2025, doi: 10.1093/gerona/glaf105. 26  "Fasting and Mitochondrial Health," Institute for Functional Medicine, Jan. 31, 2025. [Online]. Available:  https://www.ifm.org/articles/fasting-mitochondrial-health . [Accessed: Jun. 14, 2025]. 27  "New Findings Show Mitochondrial DNA Fragments in Blood as Important Biomarkers for Aging and Inflammation," Johns Hopkins Medicine, Jun. 21, 2023. [Online]. Available:  https://www.hopkinsmedicine.org/news/newsroom/news-releases/2023/06/new-findings-show-mitochondrial-dna-fragments-in-blood-as-important-biomarkers-for-aging-and-inflammation . [Accessed: Jun. 14, 2025].

b cut

The enhanced "b cut" protocol incorporates the powerhouse of Sun Chlorella, making it a triad of synergistic supplements designed for women in their perimenopausal phase. This revamped formula aims to holistically manage metabolic imbalances, support urogenital health, and promote overall vitality. Berberine GT remains a cornerstone, bringing its 500 mg of berberine HCl to the table for excellent glucose and insulin management. Its 200 mg of decaffeinated green tea complements berberine's function, aiding in healthy fat metabolism and supporting weight maintenance, giving you a dual-action solution for metabolic health in a convenient capsule form. UltraFlora Women's maintains its pivotal role in supporting vaginal, immune, and urinary tract health. It's formulated with Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14, probiotic strains clinically shown to offer comprehensive urogenital support. This one-a-day capsule is dairy-free, gluten-free, and non-GMO, accommodating various lifestyle needs. Introducing Sun Chlorella—a natural detoxifier that's a game-changer for those looking to manage weight, especially during the complex hormonal shifts of perimenopause. Chlorella has been shown to support hormonal regulation, metabolism, and energy levels. Even more compelling, it assists in flushing out stored toxins that may be released during weight loss, providing a cleaner, more efficient metabolic function. According to research in the Journal of Medicinal Food, chlorella has shown significant promise in reducing body fat percentage, fasting blood glucose levels, and overall cholesterol. Together, these three supplements offer a robust, comprehensive approach to tackling the unique health challenges busy female professionals face, especially during the hormonal fluctuations of perimenopause. The "b cut" protocol is straightforward in its use, allowing for easy integration into your daily routine for continuous, multifaceted support. Your path to reclaiming your vitality has never been this empowered. With the enhanced "b cut" protocol, you are taking a holistic approach to managing your health, focusing not just on individual symptoms but your well-being as a whole.

b charged

Introducing "b charged," a specially formulated supplement protocol designed to help treat and prevent fatigue and increase energy. Crafted with the unique needs of perimenopausal women in mind, this holistic approach combines three key supplements: Adreset, Ceriva®, and Ashwagandha Plus. Adreset aims to address stress-induced fatigue with its blend of adaptogens, including cordyceps, ginseng, and rhodiola extracts. These herbs are known for their efficacy in supporting the body's adaptive response to stress, particularly via their influence on the Hypothalamic-Pituitary-Adrenal (HPA) axis. The capsule form makes it convenient, and with 60 capsules per container, it offers a full month of relief. Ceriva® is another crucial part of the "b charged" protocol, is formulated to support healthy cognition and memory by beneficially modulating the metabolism of the neurotransmitter acetylcholine and aiding neuroprotection. This comprehensive "b charged" protocol focuses on the multifaceted aspects of well-being, addressing physical fatigue, mental stress, and promoting restful sleep. Each component serves a purpose, targeting different systems in the body involved in the stress response, relaxation, and overall vitality. The protocol is designed for busy female professionals who juggle multiple responsibilities and experience the symptoms of perimenopausal hormone fluctuations. It is a proactive step towards reclaiming your vitality and well-being. [Avoid Ceriva use if taking acetylcholinesterase inhibitors or cholinergic medications, or if you have a seizure disorder, cardiac arrhythmia, benign prostatic hypertrophy, asthma, chronic respiratory condition, peptic ulcer, inflammatory bowel disease, or malabsorption syndrome. If you have suppressed immune function or are taking medication, including blood thinning medications and immunomodulators, consult your healthcare practitioner before use. Rare but mild and temporary anxiety, mood change, sleep disturbance, dizziness, or fatigue may be experienced. Do not exceed two tablets daily. Use with caution when driving or operating machinery. Keep out of the reach of children.]

b cool

At Bonza Health, we understand the complexities that come with perimenopause, especially when dealing with disruptive symptoms like hot flashes and night sweats. In a phase of life where you're juggling a demanding career, children, and maybe even elderly parents, these symptoms can feel debilitating. That's why we’ve formulated a comprehensive supplement protocol called "b cool." b cool: Comprehensive Relief from Hot Flashes and Night Sweats The "b cool" protocol marries two highly researched and effective supplements: Estrovera® and FemmenessencePRO Peri, designed to holistically address the root causes of these symptoms, not just mask them. Estrovera® Key Ingredient: Rhapontic Rhubarb Root Extract (ERr 731®): Clinically proven to relieve up to 12 of the most common symptoms of menopause, including hot flashes and night sweats, by up to 83%. Benefits: Relief for hot flashes, night sweats, sleep disturbances, and menopausal anxiety within 1-4 weeks. Hormone-free, non-GMO, gluten-free, and vegetarian. Usage: Take one tablet with food and a glass of water once daily at the same time of day or as directed by your healthcare practitioner. FemmenessencePRO Peri Key Ingredient: MacaLife®: A proprietary, highly concentrated combination of specific maca phenotypes, specifically designed to address perimenopausal symptoms. Benefits: Nourishes the Hypothalamus Pituitary Adrenal Axis (HPA Axis), supporting the body’s own hormone production. Supports hormone balance, adrenal hormones, and energy levels, in addition to reducing hot flashes and night sweats. Usage: Standard dose: 1 capsule, twice daily, away from meals. After 4-8 months, you can reduce the dose to half the original dose. How "b cool" Works: When combined, Estrovera® and FemmenessencePRO Peri offer a comprehensive approach to managing hot flashes and night sweats. While Estrovera® aims to reduce the intensity and frequency of these symptoms, FemmenessencePRO Peri targets the root cause by nourishing the HPA Axis and supporting your body’s own hormone production. Important Disclaimer: Before starting on "b cool" or any new supplement protocol, it's vital to consult your healthcare provider. This is especially true if you're pregnant, nursing, or taking medication. These products are not intended to diagnose, treat, cure, or prevent any disease. Our "b cool" protocol is about embracing the spectrum of women’s health needs during perimenopause. It works best when integrated with lifestyle changes that include a balanced diet, physical activity, and stress management techniques. Take control of your perimenopausal journey with "b cool" and feel more comfortable and empowered in your own skin. Let's navigate these changes together.

b calm

At Bonza Health, our focus is on providing a holistic approach to managing perimenopausal symptoms, acknowledging that mood fluctuations can be one of the most challenging aspects to navigate. With that in mind, we'd like to discuss the potential benefits of incorporating SeroSyn™ and OmegaGenics® EPA 1200 into your regimen to support mood and emotional well-being during perimenopause. SeroSyn™ Key Ingredients: 5-HTP: Involved in serotonin production, which plays a critical role in mood regulation. Theanine: An amino acid found in tea leaves, known to promote relaxation. Usage: This product comes in capsule form and aims to support a calm, positive mood through modulation of serotonin metabolism. OmegaGenics® EPA 1200 Key Ingredients: EPA (Eicosapentaenoic Acid): An omega-3 fatty acid essential for brain function and known to assist in regulating mood. Usage: Offered in softgel form, this supplement provides a high concentration of EPA from sustainably sourced cold-water fish. Each softgel contains 1,200 mg of EPA, which not only supports cardiovascular health but also contributes to a healthy mood. The third cornerstone is MetaRelax, a magnesium amino acid chelate blend in a delightful orange citrus flavor. Magnesium plays a vital role in muscle relaxation and bone formation. The inclusion of vitamins B6, B12, and folate contributes to the synthesis of neurotransmitters linked to mood, sleep, and relaxation. The presence of taurine, an amino acid abundant in the central nervous system, is an added bonus for supporting brain health. Important Disclaimer: Before starting any new supplement regimen, it's essential to consult your primary care provider, especially if you have been diagnosed with a mental illness in the past, including but not limited to bipolar disorder, schizophrenia, or a history of self-harm. Supplements can offer additional support in managing the emotional and physical symptoms of perimenopause, but they should be part of a broader wellness strategy that includes a balanced diet, regular exercise, and appropriate medical consultation. Here at Bonza Health, we encourage you to consider this information as part of your self-empowered journey through perimenopause. Together, we'll find the best ways for you to reclaim your vitality.

Estrogen dominance, progesterone deficiency and stress