Protocols
Explore 12 curated protocols with guidance built by Dr. Ronald Hoffman.
Intelligent Medicine Sleep Protocol




Sleep difficulties are all too prevalent, and can have myriad negative effects on both your daily life and physical health. Still, many who suffer from troubled sleep are reluctant to rely on prescription sleep aids. To support those seeking a more natural approach to improved sleep, I’ve created the Intelligent Medicine Sleep Protocol. These selections are tailored for helping your body relax and establish a more regular sleep rhythm. Cortisol Manager: A known adaptogen, ashwagandha has been shown to rein in elevated cortisol. Preferably take 500 mg one or two at bedtime. (Take one to two daily, at bedtime.) Sleep Support: Combining a powerful blend of sleep-promoting botanicals along with L-Theanine and GABA (gamma-amino butyric acid), Sleep Support promotes relaxation and alleviates occasional sleeplessness. (Take two at bedtime.) Melatonin-SR: Formulated to deliver melatonin gradually over 6–8 hours to mimic natural secretion patterns, Melatonin-SR contains 2 mg of sustained-release melatonin per capsule to support normal, healthy sleep onset and maintenance. (Take one at bedtime.) MagSoothe™: A great-tasting, fast-acting powder that utilizes the power of highly bioavailable magnesium glycinate to support healthy, restful sleep. (Take one scoop daily.)
View protocolIntelligent Medicine Women's Midlife Health Protocol


2 more items in Intelligent Medicine Women's Midlife Health ProtocolWomen's health needs—especially during the menopause transition—have gone unmet for too long. From a lack of research to outdated or conflicting recommendations that simply treat the symptoms of perimenopause and menopause without addressing their causes, many women are left without solutions to weather this challenging time. To that end, I'm offering a suite of products specifically designed to support women's health during midlife. FemmenessencePRO PERI is the first natural product to demonstrate, in published clinical trials, statistically significant effects on hormones in perimenopausal women by supporting the body’s own production. It contains 25% Maca-GO and 75% another phenotype specifically for perimenopausal women to support hormone balance and reduce menopausal symptoms. (Take 1 capsule twice daily with 8-16oz. of water before or between meals.) FemmenessencePRO POST is the first natural product to demonstrate, in published clinical trials, statistically significant effects on hormones in postmenopausal women by supporting the body’s own production. Maca-GO® contains a specific phenotype formulation to support hormone balance and bone health in postmenopausal women. (Take 2 capsules twice daily with 8-12oz. of water before or between meals.) Collagen Plus combines the well-known benefits of collagen and nicotinamide riboside with a supporting cast of plant extracts that have been clinically studied to support beauty from within. This pleasant-tasting powder promotes the hydration, elasticity, and strength of the skin* while reducing fine lines and wrinkles, and lightening and brightening skin pigment* (Mix 1 scoop with at least 8-12 ounces of water daily) Bone Support Formula: is a comprehensive bone support product that includes Magnesium and trace minerals, as well as Vitamins C, D and K2 to aid in the synthesis and maintenance of healthy bone tissue.* (Take 4 capsules daily with food, preferably in divided doses.) DIM 200 Plus CDG Promotes healthy hormone metabolism by supporting your body’s normal detoxification processes.* (Take one capsules daily, with a meal.)
View protocolIntelligent Medicine Stress Protocol



Life is full of challenges; it seems like more and more we're faced with situations and circumstances that raise our stress levels. Thankfully, there are natural solutions for easing some of our internal tension. I've created a protocol of must-haves for you to keep on hand to support your mental health during the times life piles on extra difficulties. These selections are tailored for helping your body weather stress and anxiety, and easing your mind when you need it most. Ashwagandha: A known adaptogen, ashwagandha has been shown to rein in elevated cortisol. Preferably take 500 mg one or two at bedtime. (Take one to two daily, at bedtime.) MagSRT®: MagSRT® gently releases 500mg (per serving) of magnesium slowly into your body to maximize absorption and avoid digestive discomfort. Their unique formula combines magnesium with P5P (Pyridoxal-5-Phosphate), the active form of Vitamin B6, to support the manufacture of serotonin and dopamine in the brain. (Take 4 tablets, once per day.) (PEA)+ with Meriva® Curcumin: Palmitoylethanolamide targets the endocannabinoid system for relaxation. ( Take two capsules daily.)
View protocolIntelligent Medicine GLP-1 Support Protocol


2 more items in Intelligent Medicine GLP-1 Support ProtocolThey’re the Holy Grail of BigPharma—weight loss drugs that really work. For my entire professional career, drug developers have been on a quest to develop drugs that peel away the pounds, only to founder. Then, in a now-legendary discovery, scientists harnessed the chemical messenger that enabled Gila monsters to withstand long periods of caloric deprivation—and voila!—a generation of revolutionary weight loss drugs was spawned. It’s estimated that 12% of American adults have tried weight loss drugs; 6% of them continue to take them. If you fall into that group, my new GLP-1 Support Protocol can help support your nutritional needs while taking these medications. Protein: People on diet drugs need to prioritize protein sources and consider adding supplemental protein in the form of healthy shakes . Aim for at least 0.8 grams of protein per pound of ideal body weight ( see IBW calculator here). For example, I’m 5’10, and even if I weighed 220, my ideal body weight is 165, thus requiring around 130 grams of protein to stave off fat loss in the face of severe caloric restriction. I would especially add creatine monohydrate because of its potential for fending off muscle wasting. (5-10 grams per day.) Because of limited food intake, it’s important to consider a multi-vitamin/mineral as nutritional insurance. I recommend Alpha Base from Ortho Molecular . (Take one, twice daily.) Eating less means fewer opportunities to obtain essential fatty acids; my choice these days is Omega-3 Rejuvenate from Big Bold Health . (Take two, once daily.) Eating less means fewer opportunities to obtain essential fatty acids; my choice these days is Omega-3 Rejuvenate from Big Bold Health . (Take two, once daily.) To address off-ramping from GLP-1 medications, when rebound weight gain looms, I recommend Calocurb , a concentrate of New Zealand hops. I’m impressed with the rigor of their research, which shows this bitter extract stimulates endogenous production of satiety hormones.
View protocolIntelligent Medicine Seasonal Immune Protocol


8 more items in Intelligent Medicine Seasonal Immune ProtocolThe best medicine is preventive medicine to bolster our immune defenses. While the Intelligent Medicine Starter Kit provides a good foundation for health, those looking to safeguard their immune systems will benefit from additional focused supplementation. Over the years I have refined my list of top supplements offering the greatest boost for your immune system when it is most needed. My patients and listeners who have followed this regimen report remarkably few instances other than the mildest respiratory infections. Give it a shot! Immune Protocol CORE supplements: Kyolic Formula 103 (take one, twice daily), a product which harnesses the documented immune-boosting effects of Aged Garlic Extract along with potent co-factors. Immpower (take one, twice daily) is my go-to for immune support. Fueled by potent ingredient AHCC (Advanced Hexose Correlated Compound), its benefits are substantiated by extensive research. I use it daily myself, and I recommend it to patients. Viracid (take one, twice daily) which contains zinc and echinacea. Essential Formulas Reg’ Activ Immune & Vitality , a unique probiotic that delivers protective glutathione. Himalayan Tartary Buckwheat (HTB) is an ancient plant with powerful immune-restoring properties. Among its myriad benefits, HTB Rejuvenate helps to strengthen immune performance*. (Take two, once daily.) Immune Protocol BOOSTER supplements: Xlear Nasal Spray : Airborne pathogens, particulates, and allergens enter our bodies through the nose and mouth where they are then absorbed, which can create an immune reaction which leads to a cold or flu. Xylitol in Xlear retards the formation of biofilms which perpetuate sinus problems. I recommend it to my patients during cold, flu, and allergy season. Vitamin C (take one, twice daily) is a mainstay of immune defense, protecting cells from free radical damage and enhancing immune function. Maintaining adequate Vitamin D (take one, once daily) levels has been associated with stronger immune function. Transfer Factor (take one, twice daily) , a colostrum-derived product that boosts the vigilance of white blood cells, and olive leaf extract ( Olivir , take one, twice daily ) that is rich in oleuropein, a potent natural antiviral NAC (take one, 1-2 times daily with food) supports healthy mucosal lining in sinus and respiratory systems, and proper lung function.
View protocolIntelligent Medicine Brain Support Protocol


6 more items in Intelligent Medicine Brain Support ProtocolMany of us wonder sometimes what’s going on with our brains, like when we can’t recall a name that should be totally familiar to us or forget why we went into the kitchen! These worries take on a little more weight as we grow older, because we do know that there’s a natural decline in short-term memory and learning ability with age – a slow, progressive decline. It has even earned a medical acronym: ARMI, for age-related memory impairment. The good news is that several nutrients and nutraceuticals have been shown to slow cognitive decline and enhance memory and mental performance. I have aggregated some of the best into my Brain Support Protocol. Brain Support Protocol CORE supplements: Neurothera (take one, twice daily) is a great combination product incorporating amino acids, as well as all the most scientifically-vetted nutraceuticals for brain support. The curcumin in Cogumin SCLP (take one, twice daily) crosses the blood-brain barrier. The B vitamins in Methyl-Action (take one, twice daily) lower homocysteine and boost brain metabolism. Phosphatidylserine (take one, twice daily) is a mainstay of memory formulas. DHA from fish oil is key to infant brain development in utero and continues to protect the brain as we age. Big Bold Health’s Omega-3 Rejuvenate is minimally-processed and sustainably-sourced from Alaska, with naturally-occuring pro-resolving mediators (PRMs) and vitamins A and D to support brain wellness and promote mental clarity.* (Take two, once daily) . Lithium is an alkali metal found in nearly all vertebrate tissue. Vital Nutrients’ lithium orotate supports healthy neurotransmitter activity*, enhances Vitamin B12 and folate transport in the brain*, and may support mental and behavioral health.* (Take one, once daily with food) . Brain Support Protocol BOOSTER supplements: Ubiquinol (take one, twice daily), acetyl-l-carnitine (take one, twice daily) , and nicotinamide riboside (take one, twice daily) are a trio of nutrients that support energy metabolism in the mitochondria of brain cells. My favorite source of nicotinamide riboside is Niacel 400 by Thorne.
View protocolIntelligent Medicine Starter Kit


3 more items in Intelligent Medicine Starter KitMany of you in my Intelligent Medicine audience have been asking for a short list of the basic supplements that I take, and would recommend as a starting point for those looking to take control of their health. I tried to keep this simple. I asked myself: What are the essential elements of a basic program that everyone could benefit from? I’ve given this a lot of thought, and here’s my list: No regimen is complete without a great multi: Alpha Base without iron capsules (take two, twice daily) . Of course, fish oil is a must, with all its great attributes for inflammation, heart, and brain, and I really like Big Bold Health’s Omega-3 Rejuvenate (take two, once daily) . Then, PhytoBenefits , formerly PhytoGuard, a combination of essential phytonutrients that I personally designed (take one, twice daily) . Because of the primacy of the microbiome in determining overall health, I added my favorite probiotic, Dr. Ohhira’s (take one, twice daily) . With benefits ranging from boosting immune processes to lowering the risk of heart disease, vitamin C is an essential nutrient that our bodies cannot produce on their own. To help you maintain proper levels, I added Ester C (take one, twice daily) . A quarter of Americans are considered vitamin D deficient , while 40% (and that’s the low estimate!) have levels lower than ideal. For those with certain health concerns, those numbers can be even higher. With that in mind, I’ve included Vitamin D3 2000IU (take once daily) as a vital component of the Intelligent Medicine Starter Kit. You can’t go wrong with this combination of basic nutrients; it’s a foundation you can build on with other specialized supplements to address additional health concerns.
View protocolIntelligent Medicine Seasonal Allergy Protocol


2 more items in Intelligent Medicine Seasonal Allergy ProtocolMost often when seasonal allergies strike, we reach for the Claritin or the Allegra, but you can save yourself a trip to the pharmacy with these natural allergy-busters. If possible, get a jump on allergies by starting supplementation early, before symptoms begin. With the right intervention, you can stop the allergic cascade before it gets out of control. Allergy Protocol CORE supplements: Xlear: Bacteria and fungi that colonize the nasal passage and hide in biofilms are recognized as foreign invaders; their presence triggers chronic hyper-activation of the cells lining the respiratory tract. Xylitol in Xlear nasal spray inhibits microbes and dissolves biofilms, resulting in clearance of mucus. (Spray in each nostril every 4-6 hours as needed.) NAC: In Europe, it’s a prescription medicine, used for reducing congestion and for thinning tenacious mucus. It’s also a precursor of glutathione, the body’s premier antioxidant. (Take one, twice daily.) Aller-All™ is a well-balanced blend of vitamins, minerals and botanicals. These nutrients are known for their ability to support the body’s balanced response to environmental and seasonal changes.* Aller-All™ combines quercetin, bromelain, and vitamin C to work together to support healthy respiratory structures and functions.* This combination is also known to support the body’s normal response to typical seasonal challenges.* Other ingredients, such as B vitamins, zinc, magnesium, and licorice root have been included to further support both the respiratory and immune systems.* (Take one tablet, three times daily.) Himalayan Tartary Buckwheat (HTB) is an ancient plant loaded with protective phytonutrients. HTB Rejuvenate is rich in bioflavonoids, which may help combat seasonal allergies. (Take two, once daily.) With its combination of isoquercitrin, vitamin C, bromelain, and bioflavonoids, Aller-C is a potent and effective combination formula designed to help maintain normal respiratory and sinus function.* (Take two, twice daily.)
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