Neuroinflammation Support

1.00 Softgel

three times per day

For 3 months

Additional notes

"CoQ10 is part of the cell's energy machinery. In 13 trials (1,126 people) it eased tiredness more than a dummy pill, with more benefit at higher doses and longer use. At 300 mg a day, this amount, pooled trials found about 1.5 to 1.9 fewer migraine attacks a month; it did not make the attacks milder. In one small fibromyalgia trial (20 people, 40 days) it eased pain and tiredness. This product itself has not been tested. Side effects are rare (1 stomach upset in 602 people in trials). If you take warfarin, do not start CoQ10 without your prescriber: in reported cases it made warfarin work less well, so your INR needs checking. Tell us first if you are pregnant or breastfeeding."

1.00 Chewable

twice per day

For 3 months

Additional notes

"PEA (palmitoylethanolamide) is a fat-based compound the body makes naturally. In 18 trials (1,196 people) it lowered pain more than a dummy pill, including nerve pain and pain without a clear tissue cause (the 'wired-in' kind), with benefit by 4 to 6 weeks. Trials used 600 to 1,200 mg a day; most were small, and one carpal tunnel trial found no help. This product itself has not been tested. No major side effects were seen in trials. It has been tested alongside some pain, nerve and mood medicines without extra side effects — still, tell us everything you take. Do not take it while pregnant or breastfeeding unless your doctor says so; it has not been studied there."

1.00 Capsule

once per day

For 3 months

Additional notes

"This is the same saffron extract (affron) at the same 28 mg a day tested in at least eight placebo trials. In the largest (202 adults with low mood, 3 months), 72% on saffron had a meaningful drop in their low-mood scores versus 54% on a dummy pill. Pooled across 34 trials, saffron eased low mood and anxiety as people rated them themselves (moderate certainty), but doctor-rated scales showed no clear change, so it is not a treatment for depression. Side effects were no more common than placebo. Do not take saffron extract if you are pregnant — saffron acts on the womb. If you take an antidepressant or other mood medicine, tell your prescriber first. If you have bipolar disorder, do not start it without your prescriber — it has not been studied there. Not studied in breastfeeding."