Protocols

Explore 46 curated protocols with guidance built by Reverse-Age Method.

The Low Ferratin/Iron Anemia Protocol
Best product for raising low iron or ferratin levels from any cause. Period. Retest at 3 months.
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The ADHD in Perimenopause Program
15 more items in The ADHD in Perimenopause Program
Start with protein. Thirty to forty grams at breakfast is the single highest-leverage change on this list, and it's food, not a supplement. If a shake is easier than a whole-food breakfast most days, Past that, match support to your actual picture rather than taking everything below. If you're the reactive, dysregulated type — rejection sensitivity, mood volatility, short fuse — saffron is my most-reached-for botanical. If working memory and word-finding are your main complaint, citicoline or alpha-GPC is the better lead. If sleep onset is the problem, the magnesium pairing plus a low dose of melatonin, taken early, does more than a higher dose taken at bedtime. For the midday crash, tyrosine and Korean red ginseng are the tools I use. A few of these are lab-gated, not default: iron only if your ferritin is low, zinc and vitamin D dosed to your actual levels. Get those checked before adding them. This is educational, not medical advice, and does not diagnose ADHD. A formal assessment and any medication decision belong to your prescriber. This works alongside your medication, never instead of it. Protein powder  — For the 30–40g breakfast target. DFH PurePaleo or PurePea for a straightforward protein powder. MitoCore if you'd rather one scoop cover your protein and your multivitamin together, with some energy support built in. Saffron (standardized affron®)  — For the dysregulated, reactive type — rejection sensitivity, mood volatility, short fuse. Not the tool for pure inattention. Caution: pregnancy, bipolar, and SSRI interactions — clear with your prescriber if either applies. Omega-3, EPA-forward  — General support, EPA-dominant ratio matters more than total dose. Magnesium L-threonate / bisglycinate  — Threonate for sleep architecture, bisglycinate for onset — different jobs, worth stocking both. L-Theanine  — Sleep efficiency and calm focus, AM and/or PM. Melatonin, low dose (1–3 mg)  — Take about an hour before your target bedtime as a clock-shifter, not at bedtime as a sedative. Phosphatidylserine  — For the hyperactive-impulsive or emotionally-dysregulated type. L-Tyrosine  — Between meals, for the getting-started, staying-on-task complaint, and for the midday crash. Citicoline / alpha-GPC  — For working memory and word-finding — the "I can't hold information anymore" complaint. Korean red ginseng  — Crash-window and energy support, AM or midday. Bacopa monnieri  — Working memory, word recall, mental flexibility. Slow — give it 8–12 weeks. Ashwagandha  — For cortisol, not focus directly — evening dose. Iron bisglycinate  — Only if your ferritin is low. Don't take by default. Zinc bisglycinate/picolinate  — Lab-gated, dose to your actual levels. Vitamin D3 + K2  — Lab-gated, dose to 25-OH-D 50–70. Methylated B / active folate + B12  — Start low, especially if you're methylation-sensitive. Start with protein. Thirty to forty grams at breakfast is the single highest-leverage change on this list, and it's food, not a supplement. If a shake is easier than a whole-food breakfast most days, MitoCore is my pick — one scoop covers your protein target and doubles as a full multivitamin, so it's one bottle instead of two, with some built-in support if fatigue is part of your picture. Past that, match support to your actual picture rather than taking everything below. If you're the reactive, dysregulated type — rejection sensitivity, mood volatility, short fuse — saffron is my most-reached-for botanical. If working memory and word-finding are your main complaint, citicoline or alpha-GPC is the better lead. If sleep onset is the problem, the magnesium pairing plus a low dose of melatonin, taken early, does more than a higher dose taken at bedtime. For the midday crash, tyrosine and Korean red ginseng are the tools I use. A few of these are lab-gated, not default: iron only if your ferritin is low, zinc and vitamin D dosed to your actual levels. Get those checked before adding them. This is educational, not medical advice, and does not diagnose ADHD. A formal assessment and any medication decision belong to your prescriber. This works alongside your medication, never instead of it. Protein powder  — For the 30–40g breakfast target. DFH PurePaleo or PurePea for a straightforward protein powder. MitoCore if you'd rather one scoop cover your protein and your multivitamin together, with some energy support built in. Saffron (standardized affron®)  — For the dysregulated, reactive type — rejection sensitivity, mood volatility, short fuse. Not the tool for pure inattention. Caution: pregnancy, bipolar, and SSRI interactions — clear with your prescriber if either applies. Omega-3, EPA-forward  — General support, EPA-dominant ratio matters more than total dose. Magnesium L-threonate / bisglycinate  — Threonate for sleep architecture, bisglycinate for onset — different jobs, worth stocking both. L-Theanine  — Sleep efficiency and calm focus, AM and/or PM. Melatonin, low dose (1–3 mg)  — Take about an hour before your target bedtime as a clock-shifter, not at bedtime as a sedative. Phosphatidylserine  — For the hyperactive-impulsive or emotionally-dysregulated type. L-Tyrosine  — Between meals, for the getting-started, staying-on-task complaint, and for the midday crash. Citicoline / alpha-GPC  — For working memory and word-finding — the "I can't hold information anymore" complaint. Korean red ginseng  — Crash-window and energy support, AM or midday. Bacopa monnieri  — Working memory, word recall, mental flexibility. Slow — give it 8–12 weeks. Ashwagandha  — For cortisol, not focus directly — evening dose. Iron bisglycinate  — Only if your ferritin is low. Don't take by default. Zinc bisglycinate/picolinate  — Lab-gated, dose to your actual levels. Vitamin D3 + K2  — Lab-gated, dose to 25-OH-D 50–70. Methylated B / active folate + B12  — Start low, especially if you're methylation-sensitive.
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HPV Clearance Protocol
11 more items in HPV Clearance Protocol
This protocol supports your body's own ability to clear HPV. Your immune system is the only thing that clears this virus — there is no antiviral that eradicates it — so everything here is aimed at immune competence and the health of your cervical tissue. Read this before you order anything: READ THIS BEFORE YOU ORDER ANYTHING. You are NOT meant to take everything on this list. Each item's instructions start with a tier tag. Take your tier and skip the rest. TIER A — everyone who is HPV-positive. Items 1 through 9. TIER B — add only if you have LSIL or CIN 1 and your gynecologist has recommended watchful waiting. TIER C — add only if a high-risk type (especially 16 or 18) is still present on repeat testing. Before any of it, the foundation, which isn't a supplement: stabilize blood sugar (protein and fat with every meal), protect 7–9 hours of sleep, lower sustained stress, and if you smoke — stop. Smoking is the single highest-leverage action available to you here. It outranks everything on this page. This is ADJUNCTIVE support. It runs alongside your Pap, HPV testing, and colposcopy. It never replaces them, and it is never a reason to delay a procedure your gynecologist recommends. Nothing here cures HPV. If your result was HSIL, ASC-H, AGC, CIN 2 or CIN 3 — or you have bleeding after sex, bleeding between periods, or new pelvic pain — contact your gynecologist now. That is the whole instruction. Run this in rounds of 3 months, and keep every appointment on your clinician's schedule. Nothing here cures HPV--only your immune system can do that. Anyone telling you otherwise is selling you something I wouldn't. Most of this isn't a supplement: Start here regardless of your result. This is the part most natural HPV protocols skip, and the part I never do — you cannot supplement past a body running on high cortisol, unstable blood sugar, and poor sleep, because those are the exact conditions that suppress the immunity you're trying to recruit. • Blood sugar — protein and fat with every meal, minimal refined sugar and flour, no all-day spike and crash. • Sleep — 7 to 9 hours, protected. This is a treatment variable, not a luxury. • Stress — sustained cortisol suppresses the exact arm of immunity that clears HPV. This is endocrinology, not a mindset tip. • Smoking — if you smoke, stopping is the single highest-leverage action available to you. It outranks everything else on this page. • Alcohol — a meaningful reduction. It impairs immunity and depletes the folate this protocol depends on.Start here regardless of your result. This is the part most natural HPV protocols skip, and the part I never do — you cannot supplement past a body running on high cortisol, unstable blood sugar, and poor sleep, because those are the exact conditions that suppress the immunity you're trying to recruit. Tier 1: For anyone HPV-positive with a normal or ASCUS Pap. -AHCC -Methylfolate -Methyl B12 -Liposomal C -MegaQuin D3/K2 -Coriolus Extract -Lycopene -Oral and vaginal probiotic This is the "positive but nothing to treat yet" situation that leaves so many women with no plan at all. AHCC is the anchor. It has the strongest human evidence of any natural agent for HPV, and the trials ran 3 to 6 months — give it that runway before you judge whether it's working. Coriolus is frequently used alongside it. Run for 3 months, keep your surveillance schedule, and retest as your clinician directs. Tier 2: Add this to Tier A only if you have LSIL or biopsy-confirmed CIN 1 AND your gynecologist has recommended watchful waiting. -Dim/IC3 -Vitamin A -Zinc Keep every scheduled Pap, HPV test, and colposcopy. ⚠️ VITAMIN A — READ THIS. High-dose vitamin A is NOT to be used in pregnancy or if pregnancy is possible. It is teratogenic. It also needs a dose ceiling and an end date — this is a targeted round with a practitioner, not a supplement you take indefinitely. ⚠️ ABOUT GREEN TEA. You will see oral green tea extract sold for HPV. Oral dosing does not deliver a meaningful benefit for cervical dysplasia — the route is the therapy. EGCG has to reach the cervix, as a compounded vaginal suppository your physician prescribes. That is why you will not find green tea capsules in this protocol. See the note on local-delivery products. Rounds of 3 months, then re-examine on your clinician's schedule. For a high-risk type — especially 16 or 18 — still present on repeat testing, with a Pap that is normal, ASCUS, or LSIL. Two things are true at once here. This is where support is most worth doing well: you are trying to convert a persistent infection into a cleared one before it ever changes tissue. It is also where surveillance discipline matters most — if cytology crosses into HSIL, ASC-H, AGC, or CIN 2+, this protocol pauses for standard of care. It does not compete with it. Continue AHCC to the full 6-month window rather than stopping at 3 months. Persistence is a marathon; the trials measured their wins in months, not weeks. THREE THINGS IN YOUR GUIDE ARE NOT ON THIS LIST. Here is exactly how to get them, so you aren't left hunting. CORIOLUS VAGINAL GEL (studied as Papilocare) Human trial data supports repair of low-grade lesions and HPV clearance. Not carried here. Order direct from the manufacturer at papilocare.com, or ask your pharmacy to source it. COMPOUNDED EGCG (GREEN TEA) VAGINAL SUPPOSITORY — commonly 150 mg Your physician prescribes it; a compounding pharmacy makes it. A word on green tea, because this is where most HPV advice goes wrong: oral green tea extract does NOT deliver a meaningful benefit for cervical dysplasia. The route is the therapy — EGCG has to reach the cervix. That is why you will not find green tea capsules on this list, and why I would not sell you one. COMPOUNDED CURCUMIN VAGINAL SUPPOSITORY Same route, same lane. Local anti-inflammatory and antiviral support. On where to buy: I'd steer you away from third-party marketplace listings for anything you're using vaginally. Storage and authenticity aren't controlled there, and this is not the place to save a few dollars.
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Histamine & Mast Cell Reset
20 more items in Histamine & Mast Cell Reset
Welcome to your Histamine & Mast Cell Reset. This protocol is exhaustive — it lists every option, organized by category, so nothing useful is left out. You are not meant to buy all of it. Start with the Foundation. Add sections only as they match your specific symptoms and situation — not everyone needs everything here. When you add the plan to your cart, you can edit the cart and remove any items you don't want before checking out. Bodies respond differently to different mechanisms. Some people notice a big shift from nervous-system support, others from clearance support, others from flare control. This takes some trial and evaluation to find what moves the needle for you — introduce one thing at a time so you know what's working. Welcome to your Histamine & Mast Cell Reset. This protocol is exhaustive — it lists every option, organized by category, so nothing useful is left out. You are not meant to buy all of it. Start with the Foundation. Add sections only as they match your specific symptoms and situation — not everyone needs everything here. When you add the plan to your cart, you can edit the cart and remove any items you don't want before checking out. Bodies respond differently to different mechanisms. Some people notice a big shift from nervous-system support, others from clearance support, others from flare control. This takes some trial and evaluation to find what moves the needle for you — introduce one thing at a time so you know what's working.
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Rx2 Reverse-Age Rx — Adrenal & Stress
2 more items in Rx2 Reverse-Age Rx — Adrenal & Stress
Your adrenals are not fatigued. They're dysregulated.   HPA axis dysregulation is very real and very common in perimenopausal women. Under chronic stress, the hypothalamic-pituitary-adrenal axis stops producing a healthy cortisol rhythm. Instead of high cortisol in the morning that tapers through the day, you get a flat curve — exhausted in the morning, wired at night.   What's in this stack and why:   •      Ashwagandha KSM-66 300-600mg — the most clinically researched adaptogen for HPA axis support and cortisol reduction. The KSM-66 extract has the strongest human trial evidence. Take in the morning.   •      Phosphatidylserine 100-200mg — supports HPA axis normalization. Particularly valuable if cortisol runs high at night. Take 1-2 hours before your cortisol peak (often 8-10pm for the wired-at-night pattern).   •      Vitamin C 1-2g/day — the adrenal glands have the highest concentration of Vitamin C of any tissue in the body. Direct cofactor for cortisol synthesis and adrenal recovery. Split into AM and PM doses.   •      HPA Adapt (Integrative Therapeutics) — Rhodiola, Eleuthero, Holy Basil, and Schisandra for Stage 2 adrenal patterns. Note: if you are Stage 3 (chronically depleted, low cortisol, exhausted), these energizing adaptogens may be too stimulating — consult Brie for a full rebuilding protocol.   •      Magnesium Glycinate — runs alongside everything for HPA support and nervous system regulation.   What to expect: adaptogens work progressively — most women notice meaningful improvement in stress resilience within 4-6 weeks.   — Brie
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B7 Reverse-Age: Balance — Surgical Menopause Protocol
4 more items in B7 Reverse-Age: Balance — Surgical Menopause Protocol
Surgical menopause is different — and it deserves to be treated differently. When menopause happens naturally, the body has years to gradually adjust to declining hormones. When it happens surgically — through hysterectomy, oophorectomy, or both — the drop is immediate and abrupt. The body goes from full hormonal production to near-zero overnight. This is one of the most physiologically significant transitions a woman can experience, and it is frequently undermanaged. This protocol is the same comprehensive four-hormone support stack as the standard menopause protocol, with two important differences: it should be initiated as soon as possible after surgery (not waited on), and it should be treated as a priority, not an optional addition. What's in this stack: Progesterone+ (Quicksilver Scientific) — 3–4 pumps at bedtime, continuous. Even without a uterus, progesterone is essential for brain health, sleep quality, mood, and cardiovascular protection. The absence of a uterus does not mean progesterone isn't needed. DHEA+ Female Hormone Tonic (Quicksilver Scientific) — 1 tsp AM. The post-surgical loss of ovarian DHEA production is significant. This is the hormonal foundation for all downstream sex hormone production. Bi-Est+ (Quicksilver Scientific) — 2 pumps BID to inner arms or thighs. Estriol + estradiol. Begin once progesterone is established. Estradiol+ (Quicksilver Scientific) — 1 pump AM, added after Bi-Est is established. Added last. Longevity Elite + Hormone Balance & Protect + Hormone Receptor Detox — ongoing indefinitely alongside HRT. A note on urgency: The research on surgical menopause is clear that delayed or absent hormone therapy increases risks for cardiovascular disease, osteoporosis, dementia, and all-cause mortality — risks that are substantially higher than for natural menopause. If you have not yet started hormone support after surgery, please reach out to Brie or your prescriber. This is time-sensitive. — Brie
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B5 Reverse-Age: Balance — Late Perimenopause Hormone Support
2 more items in B5 Reverse-Age: Balance — Late Perimenopause Hormone Support
Late perimenopause is when most women come to me saying "something is really wrong." Cycles are becoming irregular or unpredictable. Hot flashes have started. Sleep is disrupted. Brain fog is real. The window of hormonal fluctuation is at its widest. This protocol addresses all of it — with a specific, sequential approach to bioidentical hormone support that mirrors the way your body made these hormones when it was working optimally. The sequence matters: progesterone first, DHEA second, estrogen third. Never add estrogen before progesterone is established. What's in this stack and why: Progesterone+ (Quicksilver Scientific) — liposomal bioidentical progesterone. At this stage, 2–3 pumps at bedtime continuously (not just cycled). Progesterone is what allows estrogen to work safely and beneficially. It's also the primary sleep hormone, the primary anti-anxiety hormone, and the hormone that protects breast and uterine tissue. DHEA+ Female Hormone Tonic (Quicksilver Scientific) — 1 pump AM, escalating to 1–2 pumps as tolerated. Essential precursor for both estrogen and testosterone production. Supports energy, mood, libido, and adrenal function. Bi-Est+ (Quicksilver Scientific) — a 80/20 blend of estriol and estradiol. Estriol is the gentler, protective estrogen; estradiol is the most bioavailable and bioactive form. Together they address hot flashes, night sweats, vaginal dryness, brain fog, and metabolic changes. Start with 1–2 pumps BID (morning and evening) to inner arms or thighs. Always start after progesterone is established. Longevity Elite (Quicksilver Scientific) — ongoing senolytic and longevity support. Contains fisetin, resveratrol, quercetin — compounds that clear senescent "zombie" cells, activate sirtuin longevity pathways, and provide ongoing anti-aging cellular support. This runs alongside HRT indefinitely. Hormone Balance & Protect + Hormone Receptor Detox (Berkson/Quicksilver) — protective HRT companions that support healthy estrogen receptor signaling, liver estrogen metabolism, and anti-proliferative protection. Take 1 dose of each daily once estrogen support is introduced. These are not aggressive estrogen detox products — they are HRT safety companions. Who this is for: Women with irregular or skipped cycles, active hot flashes or night sweats, worsening brain fog, sleep disruption, and mood changes — the full symptomatic picture of late perimenopause. — Brie
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B3 RAM: Balance — Early Perimenopause Hormone Support
2 more items in B3 RAM: Balance — Early Perimenopause Hormone Support
Message to Patient Your hormones aren’t failing you. They’re shifting — and this is the stage where the shift becomes impossible to ignore. Mid perimenopause is the in-between: cycles are still there, but becoming less predictable. Skipping months. The rhythm you’ve had your whole life is loosening. And with it comes the first real wave of symptoms — hot flashes beginning to show up, sleep less reliable, mood less steady, brain fog starting to compete with your concentration, libido going quiet. You may not be in full hormonal transition yet, but you’re not in the same body you were two years ago, either. This protocol meets you exactly where you are. What’s in this stack and why Pro Progesterone+ (Quicksilver) — progesterone is the first hormone to decline in perimenopause, often years before estrogen follows. Topical liposomal delivery bypasses the liver, reaching tissue directly. Applied at bedtime: calms the nervous system, supports sleep architecture, reduces anxiety, protects against estrogen’s proliferative effects. 2 pumps nightly — continuously if your cycles are becoming irregular, days 14–28 if you’re still cycling with relative regularity. Nanoformulated DHEA+ Female Hormone Tonic (Quicksilver) — DHEA is the precursor to both estrogen and testosterone. In perimenopause, adrenal DHEA output begins declining, taking libido, energy, and stress resilience with it. Introduced after progesterone is established (2–4 weeks), .5-1 tsp AM. Some women notice mild androgen sensitivity (acne, irritability) — if so, reduce the dose, don’t stop entirely. Pro Bi-Est+ (Quicksilver estriol/estradiol 80:20) — added once progesterone is established and estrogen deficiency symptoms are clear: hot flashes, brain fog, vaginal dryness that’s new or worsening. Estriol-dominant blend provides the protective estrogen layer that declining ovarian output is no longer supplying. 1 pump BID to inner arms or thighs. Do not rush this introduction — progesterone first, always. Hormone Balance & Protect + Hormone Receptor Detox — support healthy estrogen metabolism and receptor sensitivity throughout the cycle. Begin when Bi-Est is introduced and maintain ongoing. These are not aggressive detox agents — they are HRT companions that keep the pathway running cleanly. Titration note Before advancing from Early Perimenopause to this protocol, pump dose within your current progesterone was adjusted first. The same applies here — increase pumps within this protocol before moving to the Late Perimenopause stack. Stage advancement is the last step, not the first response. — Brie Wieselman, L.Ac., IFMCP | Founder, Reverse Age Method  
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B2 Reverse-Age: Balance — Very Early Perimenopause Hormone Support
Early perimenopause is the most underdiagnosed and undertreated window in women's hormonal health.Your cycles may still be relatively regular. Your labs may look "normal." But your symptoms are real — and they're telling you something important: progesterone is starting to drop. It drops first, years before estrogen does, and it's responsible for more of how you feel than most people realize.What's in this stack and why:Progesterone+ (Quicksilver Scientific) — bioidentical micronized progesterone in a liposomal delivery system for superior absorption. Always start here. Take 1-2 pumps topically at bedtime. For cycling women, apply on days 14-28. Sleep onset often improves within the first week.DHEA+ Female Hormone Tonic (Quicksilver Scientific) — DHEA declines steadily from your 30s. It supports energy, libido, adrenal resilience, and serves as the building block for estrogen and testosterone. Add after progesterone is established. 1 pump AM.Phosphatidylserine — particularly valuable if cortisol runs high in the evening. Take 1-2 caps 1-2 hours before your cortisol peak.Ashwagandha KSM-66 — adaptogenic HPA support running alongside hormone optimization.Who this is for: Women still cycling (even irregularly) with worsening PMS, sleep onset difficulty, anxiety, mood changes, or shorter cycles.How to take it: AM — DHEA+ 1 pump to inner arms or thighs. PM (days 14-28 or continuously) — Progesterone+ 1-2 pumps at bedtime.— Brie
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