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Dr. Jennifer Cardinal

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  • Inflammation Relief Protocol

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    This is a self-guided protocol and is not prescriptive. Individual needs may vary. Did you know inflammation can have both POSITIVE and negative health effects? Acute inflammation works WITH the immune system to address infectious and non-infectious cellular damage. ( 1 ) However, when inflammation becomes CHRONIC, it can seriously impact health. For example, studies have shown a correlation between chronic inflammation and all-cause, cancer, cardiovascular, and cerebrovascular mortality. ( 10 )( 12 ) 👉 Combine below protocol with an anti-inflammatory diet. (see attached) A healthy whole foods-based diet is key. I have attached a free resource for you loaded with anti-inflammatory recipes. Be sure to grab the recipe bundle and the outlined meal plan with your shopping list and EVERYTHING included. The work has been done for you! 👉 Don't underestimate daily movement, stress support, adequate sleep and adequate hydration as well. (See attached resources I included for you.) The deep breathing exercises really can go a long way, just 5-10 minutes a day! 👉 Lastly, consider a proper work up - looking at bloodwork, inflammatory markers and possibly food sensitivity testing. Reach out if you need more personalized help. That's why I am here. Dr. Jennifer www.hopehealthwellness.com “Self-care is not selfish. You cannot serve from an empty vessel.” – Eleanor Brownn *Always be sure to check any supplements against your medications and consider your personal health history such as allergies. Consult with me or your PCP if you have questions. Curcumin ( Curcuma longa ) 600–1,000 mg, total per day, minimum 8–10 weeks ( 4 )( 13 ) Curcumin decreased C-reactive protein (CRP) (-0.58 mg/l), tumor necrosis factor-alpha (TNF-α) (-3.48 pg/ml), interleukin 6 (IL-6) (-1.31 pg/ml), and malondialdehyde (MDA) (-0.33 umol/l), and increased superoxide dismutase (SOD) activity (20.51 u/l) and total antioxidant capacity (TAC) (0.21 mmol/l). ( 3 ) In patients with various chronic diseases, curcumin decreased CRP (-3.67 mg/l) and hs-CRP concentrations. ( 4 )  Compared to placebo, curcumin decreased IL-6 by ~49%, TNF-α by ~63%, and MDA by ~38% in patients with diabetes mellitus. ( 13 ) Omega-3 fatty acids (EPA/DHA) 2.5 g, total per day, minimum 12 weeks ( 7 )( 15 )  In patients with various health conditions, omega-3s moderately decreased serum CRP, as well as IL-6 and TNF-α with a smaller effect. ( 5 ) Compared to placebo, omega-3 supplementation decreased total serum cortisol by 19% and IL-6 levels by 33% during a stressful event, and CRP by ~30%, IL-6 by ~22%, and TNF-α by ~16% in patients with chronic kidney disease undergoing hemodialysis. ( 7 )( 15 ) Probiotics 1.6 × 109 CFU, total per day, minimum 8 weeks ( 8 )( 11 ) Prebiotics and probiotics modulate the intestinal microbiome and decrease oxidative stress and inflammation by increasing intestinal anaerobes and maintaining the integrity of the intestinal barrier. ( 6 )  Compared to placebo, a multistrain synbiotic reduced TNF-α by ~6% and hs-CRP by ~10% in postmenopausal females with obesity and a history of hormone-receptor-positive breast cancer. ( 11 )  Compared to placebo,  Lactobacillus rhamnosus GG  reduced IL1-Beta and lipopolysaccharide concentrations by ~ 35% and ~30%, respectively, in patients with CAD. ( 8 ) Quercetin ≥ 500 mg, total per day, minimum of 8 weeks ( 2 )( 9 )( 14 ) In individuals with chronic diseases, quercetin had a large effect on decreasing IL-6 and a smaller effect on decreasing serum CRP. ( 9 )  Quercetin decreased TNF-α and IL-6 in females with polycystic ovarian syndrome .  ( 14 ) Compared to placebo, quercetin increased serum TAC by ~20% in post-myocardial infarction patients.   ( 2 ) References: Chen, L., Deng, H., Cui, H., Fang, J., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2018). Inflammatory responses and inflammation-associated diseases in organs. Oncotarget, 9(6), 7204–7218. https://doi.org/ 10.18632/oncotarget.23208   Dehghani, F., Sezavar Seyedi Jandaghi, S. H., Janani, L., Sarebanhassanabadi, M., Emamat, H., & Vafa, M. (2021). Effects of quercetin supplementation on inflammatory factors and quality of life in post-myocardial infarction patients: A double blind, placebo-controlled, randomized clinical trial. Phytotherapy Research, 35(4), 2085–2098. https://doi.org/ 10.1002/ptr.6955   (B) Dehzad, M. J., Ghalandari, H., Nouri, M., & Askarpour, M. (2023). Antioxidant and anti-inflammatory effects of curcumin/turmeric supplementation in adults: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Cytokine, 164, 156144. https://doi.org/ 10.1016/j.cyto.2023.156144  (A) Gorabi, A. M., Abbasifard, M., Imani, D., Aslani, S., Razi, B., Alizadeh, S., Bagheri-Hosseinabadi, Z., Sathyapalan, T., & Sahebkar, A. (2022). Effect of curcumin on C-reactive protein as a biomarker of systemic inflammation: An updated meta-analysis of randomized controlled trials. Phytotherapy Research, 36(1), 85–97. https://doi.org/ 10.1002/ptr.7284   (A) Kavyani, Z., Musazadeh, V., Fathi, S., Hossein Faghfouri, A., Dehghan, P., & Sarmadi, B. (2022). Efficacy of the omega-3 fatty acids supplementation on inflammatory biomarkers: An umbrella meta-analysis. International Immunopharmacology, 111, 109104. https://doi.org/ 10.1016/j.intimp.2022.109104   (A)  Lopes, R. de C. S. O., Balbino, K. P., Jorge, M. D. P., Ribeiro, A. Q., Martino, H. S. D., & Alfenas, R. D. C. G. (2018). Modulation of intestinal microbiota, control of nitrogen products and inflammation by pre/probiotics in chronic kidney disease: A systematic review. Nutricion Hospitalaria, 35(3), 722–730. https://doi.org/ 10.20960/nh.1642   (A) Madison, A. A., Belury, M. A., Andridge, R., Renna, M. E., Rosie Shrout, M., Malarkey, W. B., Lin, J., Epel, E. S., & Kiecolt-Glaser, J. K. (2021). Omega-3 supplementation and stress reactivity of cellular aging biomarkers: An ancillary substudy of a randomized, controlled trial in midlife adults. Molecular Psychiatry, 26(7), 3034–3042. https://doi.org/ 10.1038/s41380-021-01077-2   (B) Moludi, J., Kafil, H. S., Qaisar, S. A., Gholizadeh, P., Alizadeh, M., & Vayghyan, H. J. (2021). Effect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: A double blind placebo controlled randomized clinical trial. Nutrition Journal, 20(1), 47. https://doi.org/ 10.1186/s12937-021-00703-7   (C) Ou, Q., Zheng, Z., Zhao, Y., & Lin, W. (2020). Impact of quercetin on systemic levels of inflammation: A meta-analysis of randomised controlled human trials. International Journal of Food Sciences and Nutrition, 71(2), 152–163. https://doi.org/ 10.1080/09637486.2019.1627515   (A) Proctor, M. J., McMillan, D. C., Horgan, P. G., Fletcher, C. D., Talwar, D., & Morrison, D. S. (2015). Systemic inflammation predicts all-cause mortality: A glasgow inflammation outcome study. PloS One, 10(3), e0116206. https://doi.org/ 10.1371/journal.pone.0116206 Raji Lahiji, M., Zarrati, M., Najafi, S., Yazdani, B., Cheshmazar, E., Razmpoosh, E., Janani, L., Raji Lahiji, M., & Shidfar, F. (2021). Effects of synbiotic supplementation on serum adiponectin and inflammation status of overweight and obese breast cancer survivors: A randomized, triple-blind, placebo-controlled trial. Supportive Care in Cancer, 29(7), 4147–4157. https://doi.org/ 10.1007/s00520-020-05926-8   (B) Sharif, S., Van der Graaf, Y., Cramer, M. J., Kapelle, L. J., de Borst, G. J., Visseren, F. L. J., Westerink, J., & SMART study group. (2021). Low-grade inflammation as a risk factor for cardiovascular events and all-cause mortality in patients with type 2 diabetes. Cardiovascular Diabetology, 20(1), 220. https://doi.org/ 10.1186/s12933-021-01409-0 Usharani, P., Mateen, A. A., Naidu, M. U. R., Raju, Y. S. N., & Chandra, N. (2008). Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: A randomized, parallel-group, placebo-controlled, 8-week study. Drugs in R&D, 9(4), 243–250. https://doi.org/ 10.2165/00126839-200809040-00004   (B) Vaez, S., Parivr, K., Amidi, F., Rudbari, N. H., Moini, A., & Amini, N. (2023). Quercetin and polycystic ovary syndrome; inflammation, hormonal parameters and pregnancy outcome: A randomized clinical trial. American Journal of Reproductive Immunology , 89(3), e13644. https://doi.org/ 10.1111/aji.13644   (B) Valle Flores, J. A., Fariño Cortéz, J. E., Mayner Tresol, G. A., Perozo Romero, J., Blasco Carlos, M., & Nestares, T. (2020). Oral supplementation with omega-3 fatty acids and inflammation markers in patients with chronic kidney disease in hemodialysis. Applied Physiology, Nutrition, and Metabolism, 45(8), 805–811. https://doi.org/ 10.1139/apnm-2019-0729   (

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  • Dr. Jennifer's Metabolic Health – Blood Sugar Support

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    This is a self-guided protocol and not prescriptive. Individual needs may vary. Be sure to grab the attached resources including: Mediterranean 30-Day Meal Plan & Recipe Pack My "Sugar Regulation" Guide Mediterranean Diet Guide Notes: 1.) HbA1c is the best blood test to assess your blood sugar or even better yet a continuous blood glucose monitoring device. You can find a link to one I recommend inside my Sugar Regulation Support Guide which is attached. 2.) Consider the below protocol alongside a Mediterranean Diet (see attached meal plan and recipe pack) and re-test in 3-6 months. 3.) Adequate sleep. exercise and stress management are also important pieces with blood sugar regulation. If you need more personalized support, reach out. I would love to help. Dr. Jennifer www.hopehealthwellness.com “Self-care is not selfish. You cannot serve from an empty vessel.” – Eleanor Brown ⭐Be sure to check supplements against any current supplements and/or medications that you are taking. Reach out to me or your physician for guided support.

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  • Dr. Jennifer's Better Sleep Support

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    This is a self-guided protocol and NOT prescriptive. Individual needs may vary. Be sure to grab the attached resources including: Sleep Diary Essential Oils for Sleep My "Reset Your Circadian Rhythm" Guide Consider trying this protocol for 30 days to start, if you continue to struggle then reach out for a more personalized, targeted approach. I would love to help. *Be sure to check any supplements against your medications and be aware of your personal health history such as allergies. Consult with me or your PCP if you have any questions. Dr. Jennifer www.hopehealthwellness.com “Self-care is not selfish. You cannot serve from an empty vessel.” - Eleanor Brownn

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  • Dr. Jennifer's Perimenopause/Menopause Supplemental Support Considerations

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    This is a self-guided protocol, not a prescription, and individual needs will vary. Below are the supplemental support products for perimenopause and menopause from my Perimenopause/Menopause Empowerment Guide (see attached). ⭐Important Notes: Supplements should never replace a healthy diet and lifestyle—these are always your foundation. Check out my 'top picks for foundational hormone support' protocol, which can be paired with this one. You don’t necessarily need everything on this list—start with a few products and see how you feel. I’ve included my HAPPY HORMONE recipe bundle and meal plan with a shopping list, outlined plan, and hormone-friendly recipes. Also, no hormone discussion is complete without addressing endocrine disruptors that affect healthy hormone signaling—see my complimentary Clean-Living Products Guide with links to safe products. Always cross-check supplements with your medications and consult your physician if needed. As a certified bioidentical hormone therapy physician, I also offer a BIOIDENTICAL HORMONE THERAPY guide (see attached) and wholesale pricing on DUTCH comprehensive hormone testing . I use diet, lifestyle, targeted supplements, and bioidenticals to help women feel and function better through this life stage. You don’t have to struggle or go through it alone. Reach out for more personalized support - I would love to help! With every blessing – Dr. Jennifer Cardinal 💗 www.hopehealthwellness.com

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  • 5 R's to Rock Your Gut Health - Supplemental Support Recommendations

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    These supplement recommendations go along with the 5 R's to Rock Your Gut Health Handguide and the Gut Solution Elimination Diet. (See attached) This is a self-guided protocol and a solid place to start. 👉 Keep in mind individual needs may vary. You need to only choose one of EACH the following (as needed, refer to attached guide): 1.) Digestive Enzymes (Enzymedica OR Pure Encapsulations) 2.) Betain HCL Pepsin (Thorne OR DFH) 3.) Garden of Life Probiotic Support OR Microbiome MegaSpore Probiotic (you can also alternate between the two for diversity) Along with: 1.) Nordic Naturals Omega 3 Support 2.) Vital Proteins Collagen Peptides *Be sure to crosscheck supplements with any other supplements or medications you are taking. For more personalized support, I would love to help. 👉👉 Gut testing is BEST to get a better understanding of what is going on with your microbiome and gut health for a more targeted approach. I have particular tests that I use and recommend with wholesale physician pricing for patients. If you want to learn more, reach out. With every blessing- Dr. Jennifer www.hopehealthwellness.com

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  • Dr. Jennifer's Favorites for Foundational Hormone Support

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    THIS IS A SELF GUIDED PROTOCOL - NOT PRESCRIPTIVE. *Individual needs may vary. These are six of my favorite nutrients to support foundational hormone health plus one adaptogenic herb, maca. These are foundational nutrients to support your hormone health whether you have symptoms or not. The maca can be optional for symptoms like low energy, hot flashes, sleep disturbances, weight gain, etc. It is a powerful adaptogenic herb that helps our body naturally regulate stress and hormonal balance. Note that the Nordic Natural Omega 3 has Vitamin D3 included so you are getting two nutrients in one with this product. Make sure you have your Vitamin D levels checked yearly to truly understand your specific needs - you may need less or more! Struggling? Try this protocol for a 30-day trial and if you continue to struggle, consider a deeper dive with a more personalized, targeted approach. Reach out to me for my wholesale pricing on comprehensive hormone testing with DUTCH hormone labs. Home - DUTCH Test Foundational support is IMPORTANT, and this is a GREAT starting point, but depending on the individual, it may or may not be enough. Perimenopause/Menopause? I am a certified bioidentical hormone therapy physician. If you are interested in exploring if hormone therapy is right for you - reach out for a complimentary consultation. BONUS MATERIALS FOR YOU! 👉Grab the attached handout on endocrine disruptors too, this is an important piece with hormone health. These disruptors block or alter hormone receptors and subsequent signaling. No hormone program is complete without addressing this piece and minimizing this impact. 👉I have also included a toxin-free guide with links to clean products; all the work has been done for you! 👉Lastly, grab my happy hormone recipe bundle and meal plan. Adequate nutrition is key for healthy hormone signaling and balance. With this meal plan and recipe bundle, you have everything you need - a shopping list, outlined meals, recipes and everything - it's all there for you! Having trouble with accessing any of the resources? Reach out to me: drjen@hopehealthwellness.com www.hopehealthwellness.com Stay hopeful! You CAN function better and feel better! “Self-care is not selfish. You cannot serve from an empty vessel.” - Eleanor Brownn *Always be sure to check any supplements against your medications and consider your personal health history such as allergies. Consult with me or your PCP if you have questions. ~Dr. Jennifer ❤️ www.hopehealthwellness.com

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