Brain & Memory Support — Comprehensive

2.00 Capsules

once per day

Additional notes

"TIER 2. ~1,000 mg/day. Two DB-RCTs - MCI (16 wks) and early AD (~1 yr); NGF/BDNF mechanism. The AD trial used an erinacine A-enriched form; this is a quality fruiting-body extract. A real cognitive signal, not just preclinical. Benefit fades on stopping - but so does the benefit of the approved symptomatic drugs, so keep it ongoing rather than counting that against it."

1 Capsule

morning

Additional notes

"TIER 2. ~30 mg/day - among the strongest botanical AD evidence. Multiple DB-RCTs. Head-to-head trials: non-inferior to donepezil (mild-moderate) and comparable to memantine over 1 yr (moderate-severe), with a favorable safety profile."

2 Capsules

once per day

Additional notes

"TIER 2. 240 mg/day total (2 x 120 mg) - the trial dose. Standardized extract, EGb 761-type. Mixed but real: RCTs/meta-analyses positive for symptomatic mild-moderate dementia, especially neuropsychiatric symptoms; WFSBP rates it comparably to cholinesterase inhibitors. Prevention trials negative. CAUTIONS: counts toward the bleeding stack conservatively; hold ~2 weeks before any procedure; caution with anticoagulants/antiplatelets and in seizure disorders or with antiepileptics."

1.00 Capsule

once per day

Additional notes

"TIER 2. ~300 mg standardized extract (>=50% bacosides). Moderate evidence - multiple RCTs and meta-analyses for memory. NEEDS 8-12 WEEKS to judge; do not call it a failure before then. Note: can be combined with shankhapushpi whole-herb powder (Banyan) as a single evening-weighted mix - see my Amazon list, since shankhapushpi is not in this catalog. Introduce the pair as ONE new item."

2.00 Capsules

once per day

Additional notes

"TIER 2. High-absorption form - this matters. Earlier curcumin trials failed on absorption, not mechanism. An 18-month DB-RCT of a bioavailable form improved memory and attention and lowered amyloid/tau on PET. Plain curcumin powder is poorly absorbed and is not a substitute. CAUTION: counts toward the bleeding stack."

1.00 Tablet

once per day

Additional notes

"TIER 2. ~500 mg 1-2x/day. CYCLE IT: 4-6 weeks on, then a break - do not run continuously. Preliminary evidence; microcirculation rationale. LIVER MONITORING REQUIRED. Stop immediately and call for yellowing skin or eyes, dark urine, right-upper-belly pain, or severe fatigue."

1.00 Scoop

once per day

Additional notes

"TIER 2. 3-5 g/day. Moderate evidence for cognition and energy. Cheap and safe - one of the better value items here. Keep well hydrated. Also supports the resistance-training side of the foundation, so it does double duty."

2.00 Softgel Capsules

once per day

Additional notes

"TIER 1. ~1 g/day, DHA-forward. Vegan algae source - no fish oil. Moderate evidence, strongest earlier in disease. Kept modest ON PURPOSE: it counts toward the bleeding stack. If using Souvenaid, do not add a full separate omega-3 dose on top - Souvenaid already supplies DHA/EPA. Have the physician reconcile the total."

1.00 Capsule

once per day

Additional notes

"TIER 1. ~200 mg/day, in divided doses with meals. Foundational and low-risk. Glycinate form is gentle on the gut and sleep-supportive - which is why it is the form chosen here; sleep is the master lever for glymphatic clearance (see 1B)."

1.00 Capsule

once per day

Additional notes

"TIER 1. Standard combined dose (folate, B6, B12). Moderate evidence - best when homocysteine is elevated, so CHECK HOMOCYSTEINE first and use that to decide. Methylated forms. Souvenaid redundancy: if he uses Souvenaid, it already contains folate/B6/B12 - do not stack a full separate B-complex on top. Use one route or the other and have the physician reconcile."

1.00 Tablet

once per day

Additional notes

"TIER 1. Vegan D3 from lichen - not lanolin. TEST FIRST, then correct to a normal 25-OH-D and do not overshoot. Moderate evidence, and specifically for correcting deficiency - this is a replacement strategy, not a cognitive enhancer. Consider pairing with K2."

1.00 Capsule

once per day

Additional notes

"INVESTIGATIONAL - reasonable to try. ~300 mg/day. NAD+ precursor; well-tolerated and harmless. Honest framing: this lacks definitive Alzheimer's trials. It is included because the risk and cost are low, which is the rule for keeping anything in this tier - not because it is established therapy."

1.00 Tablet

once per day

Additional notes

"INVESTIGATIONAL - reasonable to try. ~250-500 mg/day. PURITY IS THE WHOLE ISSUE: use a purity-verified product to avoid heavy-metal contamination. Do not buy unverified shilajit. Low cost, low risk with controlled sourcing - which is the only reason it clears the rule for this tier."

1.00 Chewable

once per day

Additional notes

"TRADITIONAL - digestive support, not a cognitive claim. 3 tablets on waking and before bed. IMPORTANT TIMING: keep it away from other supplements - the tannins bind minerals. Included for regularity and comfort, which matter for daily function and sleep. It is here because it fits this patient and is low-risk, not for a memory claim."